iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.40e-09	36.8	212	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 212  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 258
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLGQQQQLYS SAALLTGERS RLLTCYVQDY LECVESLPHD MQRNVSVLRE LDNKYQETLK 60
EIDDVYEKYK KEDDSNQKKR LQQHLQRALI NSQELGDEKI QIVTQMLELV ENRARQMELH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCAAGTCC ACTGAGACTC CGACAGGCAA GGAGGCTGAT AGCGAGGCGA GAGGATAGCG 60
AGGGTCTTGT CACGGGGATC CGGGCGACCG GGCAGCTCTG GTGGTGTCTG GGGAGTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

KEGG

rno:290744

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	96.43	1.00e-118	419.00
IUUC-Apl-003705	Anas platyrhynchos	87.00	3.00e-90	324.00
IUUC-Aca-004990	Anolis carolinensis	80.31	3.00e-97	348.00
IUUC-Ame-011426	Astyanax mexicanus	69.34	5.00e-82	297.00
IUUC-Bta-012721	Bos taurus	97.79	4.00e-120	423.00
IUUC-Cja-018960	Callithrix jacchus	96.59	5.00e-105	373.00
IUUC-Cfa-020869	Canis familiaris	96.43	2.00e-118	418.00
IUUC-Cpo-021414	Cavia porcellus	95.36	1.00e-117	415.00
IUUC-Csa-023304	Chlorocebus sabaeus	96.43	6.00e-110	390.00
IUUC-Dre-028562	Danio rerio	67.16	1.00e-86	312.00
IUUC-Dno-029945	Dasypus novemcinctus	96.59	2.00e-114	404.00
IUUC-Dor-030141	Dipodomys ordii	96.07	4.00e-117	413.00
IUUC-Ete-032709	Echinops telfairi	94.85	2.00e-126	444.00
IUUC-Eca-033432	Equus caballus	97.43	6.00e-119	420.00
IUUC-Eeu-035285	Erinaceus europaeus	96.10	3.00e-89	320.00
IUUC-Fca-036467	Felis catus	96.97	3.00e-114	404.00
IUUC-Fal-036700	Ficedula albicollis	85.78	1.00e-89	322.00
IUUC-Gmo-038748	Gadus morhua	63.41	8.00e-86	310.00
IUUC-Gga-040175	Gallus gallus	86.55	4.00e-90	323.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	2.00e-89	322.00
IUUC-Hsa-045837	Homo sapiens	96.43	6.00e-110	390.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.14	1.00e-119	422.00
IUUC-Lch-049965	Latimeria chalumnae	78.63	7.00e-98	350.00
IUUC-Laf-053353	Loxodonta africana	94.67	7.00e-99	352.00
IUUC-Mcc-055155	Macaca mulatta	95.98	2.00e-71	261.00
IUUC-Meu-056470	Macropus eugenii	91.73	5.00e-110	390.00
IUUC-Mga-059570	Meleagris gallopavo	86.55	1.00e-89	322.00
IUUC-Mmr-061385	Microcebus murinus	96.79	2.00e-110	392.00
IUUC-Mdo-062144	Monodelphis domestica	91.80	2.00e-111	394.00
IUUC-Mmu-063215	Mus musculus	97.86	3.00e-121	427.00
IUUC-Mpu-065749	Mustela putorius furo	95.82	6.00e-98	349.00
IUUC-Nle-069968	Nomascus leucogenys	95.79	4.00e-80	290.00
IUUC-Ont-071524	Oreochromis niloticus	65.57	2.00e-86	312.00
IUUC-Ocu-074870	Oryctolagus cuniculus	97.43	1.00e-119	422.00
IUUC-Oga-088336	Otolemur garnettii	96.69	9.00e-110	389.00
IUUC-Oar-090136	Ovis aries	97.41	2.00e-118	417.00
IUUC-Ptr-091348	Pan troglodytes	96.32	8.00e-81	293.00
IUUC-Pan-092819	Papio anubis	96.43	6.00e-110	390.00
IUUC-Pfo-096633	Poecilia formosa	63.67	1.00e-80	292.00
IUUC-Pab-098346	Pongo abelii	96.07	1.00e-109	389.00
IUUC-Pca-100278	Procavia capensis	94.09	7.00e-116	409.00
IUUC-Pva-103190	Pteropus vampyrus	97.73	3.00e-115	407.00
IUUC-Sha-107533	Sarcophilus harrisii	90.07	3.00e-112	397.00
IUUC-Sar-113630	Sorex araneus	94.15	2.00e-88	318.00
IUUC-Ssc-115734	Sus scrofa	97.73	3.00e-115	407.00
IUUC-Tgu-117034	Taeniopygia guttata	86.22	4.00e-90	323.00
IUUC-Tru-118168	Takifugu rubripes	59.52	5.00e-80	290.00
IUUC-Tsy-119494	Tarsius syrichta	96.84	2.00e-81	294.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.48	8.00e-78	283.00
IUUC-Ttr-128442	Tursiops truncatus	97.56	1.00e-90	325.00
IUUC-Vpa-130063	Vicugna pacos	96.07	3.00e-118	417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence