iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033596

UUCD1 version

UUC-EqC-00537

Ensembl Protein ID

ENSECAP00000007693.1

UniProt Accession

F6YUY8; F6YUY8_HORSE

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000009626.1	ENSECAT00000010015.1	ENSECAP00000007693.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	4.20e-38	131.0	93	262
UBD/ZnF/ZnF_A20	1.50e-23	82.6	756	789

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++g+ d+d+ l++al+++L+e+ ++++    q es + +ef+e++         +e++ + ++++ +   
   Q: 93   VALKTNGDGNCLMHAASQYMWGIPDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwTEEWDTLIRMASADtpg 181
           789**********************************************9*********************99***********99554 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+g       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++  ++pivL+Y+s+H+ +Lv+
   Q: 182  ARGglqysslEEIHIFVLCNILRRPIIVISDKMLRSldsgsnfaplKVGGIYLPLHWPAQEcCRYPIVLGYDSHHFVPLVT 262
           44389999*****************************************************99****************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k++C++ +C+++Gn+++ gyC++C++++++++
   Q: 756  PPKQRCRApACDHFGNAKCSGYCNECFQFKQMYG 789
           9*******************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MAEHVLPQAL YLSNMRKAVK IRERTPEDLF KPTNGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHKALID RNIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAASQ YMWGIPDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAGC ACGTCCTTCC TCAGGCTCTG TATCTGAGCA ACATGCGGAA AGCTGTGAAG 60
ATAAGAGAGC GGACTCCAGA AGACCTTTTC AAACCTACCA ATGGAATCAT TCATCATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

ecb:100073197

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	88.61	0.00e+00	1452.00
IUUC-Apl-003501	Anas platyrhynchos	66.41	0.00e+00	1052.00
IUUC-Aca-004245	Anolis carolinensis	62.62	0.00e+00	1023.00
IUUC-Ame-011789	Astyanax mexicanus	46.61	0.00e+00	684.00
IUUC-Bta-012664	Bos taurus	84.18	0.00e+00	1337.00
IUUC-Cja-019895	Callithrix jacchus	87.47	0.00e+00	1428.00
IUUC-Cfa-020754	Canis familiaris	88.10	0.00e+00	1448.00
IUUC-Cpo-021780	Cavia porcellus	85.08	0.00e+00	1389.00
IUUC-Csa-023568	Chlorocebus sabaeus	87.85	0.00e+00	1446.00
IUUC-Cho-024300	Choloepus hoffmanni	87.76	0.00e+00	640.00
IUUC-Dre-028577	Danio rerio	48.57	0.00e+00	670.00
IUUC-Dno-029382	Dasypus novemcinctus	82.15	0.00e+00	1309.00
IUUC-Dor-030874	Dipodomys ordii	82.91	0.00e+00	1338.00
IUUC-Ete-032721	Echinops telfairi	87.29	0.00e+00	770.00
IUUC-Eeu-035159	Erinaceus europaeus	82.80	0.00e+00	1066.00
IUUC-Fca-035847	Felis catus	88.61	0.00e+00	1450.00
IUUC-Fal-036681	Ficedula albicollis	64.72	0.00e+00	1061.00
IUUC-Gmo-038521	Gadus morhua	57.49	2.00e-142	499.00
IUUC-Gga-040975	Gallus gallus	65.14	0.00e+00	1064.00
IUUC-Gac-042216	Gasterosteus aculeatus	58.84	9.00e-148	517.00
IUUC-Ggo-045258	Gorilla gorilla	87.22	0.00e+00	1437.00
IUUC-Hsa-046071	Homo sapiens	87.34	0.00e+00	1439.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	87.22	0.00e+00	1420.00
IUUC-Lch-050326	Latimeria chalumnae	56.89	0.00e+00	904.00
IUUC-Loc-051945	Lepisosteus oculatus	46.67	1.00e-173	603.00
IUUC-Laf-053722	Loxodonta africana	85.95	0.00e+00	1402.00
IUUC-Mcc-055503	Macaca mulatta	87.59	0.00e+00	1442.00
IUUC-Meu-056481	Macropus eugenii	72.63	0.00e+00	1150.00
IUUC-Mga-059690	Meleagris gallopavo	62.80	0.00e+00	984.00
IUUC-Mmr-061233	Microcebus murinus	86.62	0.00e+00	1405.00
IUUC-Mdo-062446	Monodelphis domestica	78.17	0.00e+00	1269.00
IUUC-Mmu-063436	Mus musculus	84.30	0.00e+00	1340.00
IUUC-Mpu-066808	Mustela putorius furo	88.86	0.00e+00	1452.00
IUUC-Mlu-067339	Myotis lucifugus	86.44	0.00e+00	1420.00
IUUC-Nle-069888	Nomascus leucogenys	87.47	0.00e+00	1440.00
IUUC-Opr-070303	Ochotona princeps	85.88	0.00e+00	1399.00
IUUC-Ont-072283	Oreochromis niloticus	56.90	1.00e-142	500.00
IUUC-Oan-072925	Ornithorhynchus anatinus	74.19	0.00e+00	1201.00
IUUC-Ocu-073889	Oryctolagus cuniculus	85.84	0.00e+00	1369.00
IUUC-Ola-087417	Oryzias latipes	57.87	7.00e-145	507.00
IUUC-Oga-088708	Otolemur garnettii	84.66	0.00e+00	1335.00
IUUC-Oar-089271	Ovis aries	84.43	0.00e+00	1350.00
IUUC-Ptr-091296	Pan troglodytes	87.34	0.00e+00	1437.00
IUUC-Pan-092474	Papio anubis	87.72	0.00e+00	1444.00
IUUC-Psi-093447	Pelodiscus sinensis	66.54	0.00e+00	1088.00
IUUC-Pfo-096511	Poecilia formosa	57.14	3.00e-144	505.00
IUUC-Pab-098700	Pongo abelii	87.59	0.00e+00	1442.00
IUUC-Pca-100246	Procavia capensis	72.78	0.00e+00	1163.00
IUUC-Pva-102606	Pteropus vampyrus	75.38	7.00e-172	597.00
IUUC-Rno-105818	Rattus norvegicus	83.44	0.00e+00	1366.00
IUUC-Sha-106559	Sarcophilus harrisii	76.79	0.00e+00	1249.00
IUUC-Sit-110516	Setaria italica	37.78	9.30e-01	29.60
IUUC-Sar-113454	Sorex araneus	91.46	0.00e+00	638.00
IUUC-Ssc-116064	Sus scrofa	86.33	0.00e+00	1385.00
IUUC-Tgu-117212	Taeniopygia guttata	65.02	0.00e+00	1056.00
IUUC-Tru-118230	Takifugu rubripes	57.63	2.00e-146	513.00
IUUC-Tsy-119066	Tarsius syrichta	83.16	0.00e+00	1363.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.26	0.00e+00	668.00
IUUC-Tbe-127601	Tupaia belangeri	92.68	0.00e+00	654.00
IUUC-Ttr-128930	Tursiops truncatus	84.56	0.00e+00	1372.00
IUUC-Vpa-130450	Vicugna pacos	90.52	0.00e+00	769.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence