iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000015424.1	ENSPSIT00000017434.1	ENSPSIP00000017356.1
ENSPSIG00000015424.1	ENSPSIT00000017442.1	ENSPSIP00000017364.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.50e-37	127.9	93	263
UBD/ZnF/ZnF_A20	3.00e-18	65.5	756	789

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe.. 74
           l++lkt+gDGnCL++A+sq+++gv+d d+ l++ l++aL+e  ++++    q+e  + +ef+e++        e+e+e++ k+ ++e  
   Q: 93   LVPLKTNGDGNCLMHAASQYMWGVQDVDLvLRKTLYSALKEVDTRNFklrwQRETIKSQEFVETGlhydtrnwEEEWENIIKMTSTEtp 181
           5789*********************************************999***********************************77 PP
   S: 75   .ak.g......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
            a+ g      eeihif+L ++L+rpiiv+++++l+s          +v+gi+lpl++p+e+ +++pivL+Y+s+H+ +L +
   Q: 182  vARsGlqynalEEIHIFVLVNVLRRPIIVLADKMLRSlesgssfsplNVSGIYLPLHWPAEEcYRYPIVLGYDSMHFTPLLT 263
           76644999999********************************************************************975 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k+ C++ gC++YGn ++ngyC++Cy+++ +++
   Q: 756  PPKQHCRAtGCDHYGNNKCNGYCNECYQFKEMYG 789
           9*****************************9985 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MAVQQVLPQA LYLSNMLKAV KIRERTPEDL VKPTNGIIHH FKTMHRYTVE MFRMCQFCPQ 60
FRETLQKALI DRPTQISLEH ERKLNWCREV RKLVPLKTNG DGNCLMHAAS QYMWGVQDVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGAGGG AGGGGGCGGC CGAGGGAAGC CCAGCCAGGC GCTGTGAAGG AGCCAGATTC 60
TCCTGCAACC CAGTCGGGTC GGGCATTCAT GGCTGCCCAG CTTAGCGCTG CCCTCGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	68.22	0.00e+00	1111.00
IUUC-Apl-003501	Anas platyrhynchos	75.28	0.00e+00	1192.00
IUUC-Aca-004245	Anolis carolinensis	70.74	0.00e+00	1159.00
IUUC-Ame-011789	Astyanax mexicanus	46.84	0.00e+00	707.00
IUUC-Bta-012664	Bos taurus	66.16	0.00e+00	1047.00
IUUC-Cja-019895	Callithrix jacchus	69.47	0.00e+00	1116.00
IUUC-Cfa-020754	Canis familiaris	68.35	0.00e+00	1112.00
IUUC-Cpo-021780	Cavia porcellus	67.71	0.00e+00	1087.00
IUUC-Csa-023568	Chlorocebus sabaeus	69.60	0.00e+00	1128.00
IUUC-Cho-024300	Choloepus hoffmanni	79.06	2.00e-165	575.00
IUUC-Dre-028577	Danio rerio	49.07	0.00e+00	699.00
IUUC-Dno-029382	Dasypus novemcinctus	66.58	0.00e+00	1066.00
IUUC-Dor-030874	Dipodomys ordii	65.95	0.00e+00	1041.00
IUUC-Ete-032721	Echinops telfairi	78.40	0.00e+00	689.00
IUUC-Eca-033596	Equus caballus	66.54	0.00e+00	1075.00
IUUC-Eeu-035159	Erinaceus europaeus	64.82	0.00e+00	820.00
IUUC-Fca-035847	Felis catus	68.26	0.00e+00	1112.00
IUUC-Fal-036681	Ficedula albicollis	72.93	0.00e+00	1195.00
IUUC-Gmo-038521	Gadus morhua	60.93	3.00e-152	532.00
IUUC-Gga-040975	Gallus gallus	74.17	0.00e+00	1225.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.89	6.00e-158	551.00
IUUC-Ggo-045258	Gorilla gorilla	69.35	0.00e+00	1119.00
IUUC-Hsa-046071	Homo sapiens	69.10	0.00e+00	1118.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	68.85	0.00e+00	1111.00
IUUC-Lch-050326	Latimeria chalumnae	56.93	0.00e+00	913.00
IUUC-Loc-051945	Lepisosteus oculatus	45.92	0.00e+00	635.00
IUUC-Laf-053722	Loxodonta africana	68.09	0.00e+00	1095.00
IUUC-Mcc-055503	Macaca mulatta	69.60	0.00e+00	1129.00
IUUC-Meu-056481	Macropus eugenii	64.62	0.00e+00	1001.00
IUUC-Mga-059690	Meleagris gallopavo	72.01	0.00e+00	1120.00
IUUC-Mmr-061233	Microcebus murinus	68.92	0.00e+00	1100.00
IUUC-Mdo-062446	Monodelphis domestica	68.74	0.00e+00	1096.00
IUUC-Mmu-063436	Mus musculus	67.25	0.00e+00	1067.00
IUUC-Mpu-066808	Mustela putorius furo	68.55	0.00e+00	1111.00
IUUC-Mlu-067339	Myotis lucifugus	69.03	0.00e+00	1096.00
IUUC-Nle-069888	Nomascus leucogenys	69.10	0.00e+00	1118.00
IUUC-Opr-070303	Ochotona princeps	68.01	0.00e+00	1086.00
IUUC-Ont-072283	Oreochromis niloticus	60.53	1.00e-152	533.00
IUUC-Oan-072925	Ornithorhynchus anatinus	69.79	0.00e+00	1136.00
IUUC-Ocu-073889	Oryctolagus cuniculus	68.35	0.00e+00	1092.00
IUUC-Olo-080600	Oryza longistaminata	36.07	1.30e+00	28.10
IUUC-Ola-087417	Oryzias latipes	61.41	4.00e-154	538.00
IUUC-Oga-088708	Otolemur garnettii	68.05	0.00e+00	1063.00
IUUC-Oar-089271	Ovis aries	66.67	0.00e+00	1061.00
IUUC-Ptr-091296	Pan troglodytes	69.10	0.00e+00	1117.00
IUUC-Pan-092474	Papio anubis	69.72	0.00e+00	1132.00
IUUC-Pfo-096511	Poecilia formosa	60.19	3.00e-153	535.00
IUUC-Pab-098700	Pongo abelii	69.22	0.00e+00	1121.00
IUUC-Pca-100246	Procavia capensis	62.95	0.00e+00	726.00
IUUC-Pva-102606	Pteropus vampyrus	66.84	1.00e-152	533.00
IUUC-Rno-105818	Rattus norvegicus	67.42	0.00e+00	1084.00
IUUC-Sha-106559	Sarcophilus harrisii	68.62	0.00e+00	1095.00
IUUC-Sit-110516	Setaria italica	42.86	3.10e-02	34.30
IUUC-Sar-113454	Sorex araneus	80.43	2.00e-164	572.00
IUUC-Ssc-116064	Sus scrofa	67.84	0.00e+00	1069.00
IUUC-Tgu-117212	Taeniopygia guttata	74.27	0.00e+00	1201.00
IUUC-Tru-118230	Takifugu rubripes	62.14	2.00e-157	548.00
IUUC-Tsy-119066	Tarsius syrichta	67.89	0.00e+00	1092.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.73	0.00e+00	679.00
IUUC-Tbe-127601	Tupaia belangeri	81.04	2.00e-166	579.00
IUUC-Ttr-128930	Tursiops truncatus	67.42	0.00e+00	1071.00
IUUC-Vpa-130450	Vicugna pacos	79.75	0.00e+00	680.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence