iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100221.10	ENST00000216039.9	ENSP00000216039.5
ENSG00000100221.10	ENST00000545590.1	ENSP00000444798.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/Josephin	Josephin	21245847

Classification

Family	E-value	Score	Start	End
DUB/Josephin	6.80e-101	337.1	1	202

Active Site

Position(s)	Description	Evidence
36	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
139	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

DUB/Josephin

   S: 1    msqvpg............aqaapesiyhekqrrelCalhalnnvlqd.elfsreeldeiakrldeeerlqPs.kslldtGnydvnvisaalk 78
           ms+vp+            +qaap++iyhekqrrelCalhalnnv+qd ++f+r++l+ei++rl+++++++P+ ks+l++Gnydvnvi+aal+
   Q: 1    MSCVPWkgdkakseslelPQAAPPQIYHEKQRRELCALHALNNVFQDsNAFTRDTLQEIFQRLSPNTMVTPHkKSMLGNGNYDVNVIMAALQ 92
           8**********************************************9************************99****************** PP
   S: 79   vlGleavwfdkrrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllqqkysel 170
           ++G+eavw+dkrr+++++al+nv+gfi+nlpssl++g+lklplk+qhW++vr+vg+ayynldsklk+Pe+ig+e+elrkfl+++l++k++el
   Q: 93   TKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGKNCEL 184
           ******************************************************************************************** PP
   S: 171  llvvkeevedkesdqrldv 189
           llvv+eeve+++s+ r+dv
   Q: 185  LLVVPEEVEAHQSW-RTDV 202
           **************.8886 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.

Protein Sequence
(Fasta)

MSCVPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRDTLQEIF 60
QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTGAAATG TGACTCCCAG CGAGACACCT ACCCTTGACG CTCCCTGGAC AGTGCGGCAC 60
GGTCGGGCCC ACTAACCAAG GCAATTTGCG CCCGACCGAA TCAGGTGCTT CAAAATCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination

KEGG

hsa:9929

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002429	Ailuropoda melanoleuca	97.52	3.00e-110	390.00
IUUC-Apl-003240	Anas platyrhynchos	89.16	6.00e-96	343.00
IUUC-Aca-004262	Anolis carolinensis	91.09	2.00e-103	367.00
IUUC-Afl-008651	Aspergillus flavus	31.88	1.10e-01	29.30
IUUC-Ame-011040	Astyanax mexicanus	70.51	2.00e-81	295.00
IUUC-Bta-012440	Bos taurus	97.52	1.00e-110	392.00
IUUC-Cja-019461	Callithrix jacchus	99.01	8.00e-112	395.00
IUUC-Cfa-021002	Canis familiaris	97.52	3.00e-110	390.00
IUUC-Cpo-021309	Cavia porcellus	98.51	1.00e-111	395.00
IUUC-Csa-023194	Chlorocebus sabaeus	99.50	8.00e-113	399.00
IUUC-Cho-025019	Choloepus hoffmanni	96.53	4.00e-110	390.00
IUUC-Cin-025666	Ciona intestinalis	59.15	7.00e-54	203.00
IUUC-Dre-028692	Danio rerio	69.91	9.00e-81	293.00
IUUC-Dno-029803	Dasypus novemcinctus	96.53	8.00e-110	389.00
IUUC-Dor-030619	Dipodomys ordii	99.29	2.00e-73	267.00
IUUC-Ete-032777	Echinops telfairi	95.72	1.00e-106	378.00
IUUC-Eca-034395	Equus caballus	97.03	1.00e-110	391.00
IUUC-Eeu-035075	Erinaceus europaeus	76.24	2.00e-78	284.00
IUUC-Fca-035819	Felis catus	97.52	8.00e-111	392.00
IUUC-Fal-037330	Ficedula albicollis	91.58	3.00e-99	353.00
IUUC-Gmo-038979	Gadus morhua	80.92	1.00e-76	278.00
IUUC-Gga-040456	Gallus gallus	94.09	2.00e-99	354.00
IUUC-Gac-041797	Gasterosteus aculeatus	74.13	4.00e-81	293.00
IUUC-Ggo-045586	Gorilla gorilla	100.00	3.00e-113	400.00
IUUC-Itr-048432	Ictidomys tridecemlineatus	98.02	4.00e-111	393.00
IUUC-Lch-049682	Latimeria chalumnae	79.70	4.00e-85	306.00
IUUC-Loc-051775	Lepisosteus oculatus	80.79	2.00e-77	281.00
IUUC-Laf-054283	Loxodonta africana	97.06	3.00e-109	387.00
IUUC-Mcc-055073	Macaca mulatta	99.48	9.00e-114	402.00
IUUC-Meu-056650	Macropus eugenii	93.07	5.00e-105	373.00
IUUC-Mga-059703	Meleagris gallopavo	94.06	9.00e-101	358.00
IUUC-Mdo-062114	Monodelphis domestica	94.06	6.00e-107	379.00
IUUC-Mmu-064230	Mus musculus	97.03	3.00e-110	390.00
IUUC-Mpu-065845	Mustela putorius furo	97.03	7.00e-110	389.00
IUUC-Mlu-067564	Myotis lucifugus	93.56	8.00e-99	352.00
IUUC-Nfi-068472	Neosartorya fischeri	30.00	2.60e-01	29.30
IUUC-Nle-069516	Nomascus leucogenys	99.50	1.00e-112	398.00
IUUC-Opr-070945	Ochotona princeps	80.20	8.00e-86	309.00
IUUC-Ont-071439	Oreochromis niloticus	70.51	8.00e-79	286.00
IUUC-Oan-073122	Ornithorhynchus anatinus	90.91	8.00e-69	251.00
IUUC-Ocu-074128	Oryctolagus cuniculus	85.12	3.00e-55	206.00
IUUC-Ola-086972	Oryzias latipes	67.94	1.00e-70	259.00
IUUC-Oga-088786	Otolemur garnettii	98.02	3.00e-118	416.00
IUUC-Oar-089212	Ovis aries	97.04	2.00e-109	387.00
IUUC-Ptr-090936	Pan troglodytes	100.00	3.00e-113	400.00
IUUC-Pan-092234	Papio anubis	100.00	3.00e-113	400.00
IUUC-Psi-093448	Pelodiscus sinensis	92.57	2.00e-103	368.00
IUUC-Pfo-096711	Poecilia formosa	81.82	6.00e-79	286.00
IUUC-Pab-097628	Pongo abelii	99.50	3.00e-111	394.00
IUUC-Pop-099793	Populus trichocarpa	35.64	3.00e-22	98.20
IUUC-Pca-100555	Procavia capensis	96.18	3.00e-86	310.00
IUUC-Pva-102259	Pteropus vampyrus	97.52	1.00e-110	392.00
IUUC-Rno-105045	Rattus norvegicus	97.03	4.00e-110	390.00
IUUC-Sha-107606	Sarcophilus harrisii	94.55	2.00e-107	381.00
IUUC-Ssc-115663	Sus scrofa	98.51	1.00e-111	395.00
IUUC-Tgu-117374	Taeniopygia guttata	91.09	1.00e-101	362.00
IUUC-Tru-118030	Takifugu rubripes	81.25	5.00e-78	283.00
IUUC-Tsy-119298	Tarsius syrichta	98.02	1.00e-110	391.00
IUUC-Tni-119797	Tetraodon nigroviridis	80.68	9.00e-78	282.00
IUUC-Tbe-127896	Tupaia belangeri	98.51	1.00e-111	395.00
IUUC-Ttr-128523	Tursiops truncatus	98.02	1.00e-110	391.00
IUUC-Vpa-130184	Vicugna pacos	95.05	4.00e-113	399.00
IUUC-Xtr-131903	Xenopus tropicalis	85.15	1.00e-94	338.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence