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Tag Content
iUUCD ID IUUC-Bta-013170
Ensembl Protein ID ENSBTAP00000036133.1
UniProt Accession Q3ZCD7; TECR_BOVIN
Genbank Protein ID AAI02504.1
Protein Name Very-long-chain enoyl-CoA reductase; Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase
Genbank Nucleotide ID BC102503
Gene Name TECR; GPSN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000012632.5 ENSBTAT00000036271.1 ENSBTAP00000036133.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 41.73 2.00e-47 184.00 IUUC-Spo-108110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
 Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Protein Sequence
(Fasta)
MKHYEVEILD AKTREKLCFL DKVEPQATIA EIKNLFTKTH PQWYPARQSL RLDPKGKSLK 60
DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF IYLLFYFRVP FIYGRKYDFT 120
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Protein Fasta Sequence


>IUUC-Bta-013170|ULD,UBQ_Other|Bos taurus
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Nucleotide Sequence
(Fasta)
AGTCTCGCGC GGCGGTCGTC CCCGCGTGAG GTACTCTGTG GTGTAGCGTG CGCAGGTAGC 60
AGGAGAAGCA GCTGCCGTGC GGGGGAGCCA TGAAGCACTA TGAGGTAAGA AAAGAGAAAA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013170|ULD,UBQ_Other|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001104--3-oxo-5_a-steroid_4-DH_C
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50244--S5A_REDUCTASE
Pfam

PF02544--Steroid_dh
Gene Ontology

GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0016491--F:oxidoreductase activity
GO:0016627--F:oxidoreductase activity, acting on the CH-CH group of donors
GO:0030497--P:fatty acid elongation
GO:0006694--P:steroid biosynthetic process
GO:0042761--P:very long-chain fatty acid biosynthetic process
KEGG bta:614105
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000125 Aegilops tauschii 41.24 3.00e-51 195.00
IUUC-Aml-001579 Ailuropoda melanoleuca 81.82 6.00e-168 583.00
IUUC-Atr-002693 Amborella trichopoda 36.99 5.00e-41 161.00
IUUC-Apl-004113 Anas platyrhynchos 75.08 3.00e-143 500.00
IUUC-Aca-004681 Anolis carolinensis 90.91 5.00e-172 596.00
IUUC-Aly-005795 Arabidopsis lyrata 40.27 2.00e-49 189.00
IUUC-Ath-007255 Arabidopsis thaliana 39.60 3.00e-49 188.00
IUUC-Ago-007822 Ashbya gossypii 33.19 4.00e-27 114.00
IUUC-Acl-008131 Aspergillus clavatus 35.91 1.00e-34 140.00
IUUC-Afl-008670 Aspergillus flavus 32.85 4.00e-33 135.00
IUUC-Afu-009058 Aspergillus fumigatus 37.93 1.00e-33 136.00
IUUC-Ani-009299 Aspergillus nidulans 39.41 4.00e-36 144.00
IUUC-Ang-009520 Aspergillus niger 37.02 8.00e-35 140.00
IUUC-Aor-010023 Aspergillus oryzae 38.55 1.00e-38 153.00
IUUC-Ate-010593 Aspergillus terreus 37.04 2.00e-33 135.00
IUUC-Ame-011087 Astyanax mexicanus 85.71 3.00e-165 573.00
IUUC-Bgr-012251 Blumeria graminis 33.00 1.00e-36 146.00
IUUC-Bci-013894 Botrytis cinerea 33.80 3.00e-41 161.00
IUUC-Bdi-015014 Brachypodium distachyon 39.80 1.00e-48 186.00
IUUC-Bol-015761 Brassica oleracea 40.47 1.00e-49 190.00
IUUC-Bra-016894 Brassica rapa 39.93 3.00e-49 188.00
IUUC-Cel-018599 Caenorhabditis elegans 53.11 6.00e-90 323.00
IUUC-Cja-019333 Callithrix jacchus 94.41 2.00e-170 590.00
IUUC-Cfa-020709 Canis familiaris 98.03 0.00e+00 628.00
IUUC-Cpo-022353 Cavia porcellus 98.05 0.00e+00 634.00
IUUC-Cre-023020 Chlamydomonas reinhardtii 40.00 2.00e-50 192.00
IUUC-Csa-023716 Chlorocebus sabaeus 98.70 0.00e+00 634.00
IUUC-Csv-025915 Ciona savignyi 62.83 6.00e-115 406.00
IUUC-Cgl-026580 Colletotrichum gloeosporioides 35.82 6.00e-41 160.00
IUUC-Cne-027086 Cryptococcus neoformans 29.87 4.00e-24 105.00
IUUC-Cme-027185 Cyanidioschyzon merolae 43.33 2.00e-57 215.00
IUUC-Dre-028710 Danio rerio 85.06 1.00e-164 572.00
IUUC-Dno-029631 Dasypus novemcinctus 51.90 9.00e-87 313.00
IUUC-Dor-030220 Dipodomys ordii 98.38 0.00e+00 635.00
IUUC-Dse-031218 Dothistroma septosporum 37.63 9.00e-45 173.00
IUUC-Dme-031792 Drosophila melanogaster 53.44 4.00e-89 321.00
IUUC-Ete-032441 Echinops telfairi 87.17 4.00e-93 334.00
IUUC-Eca-033372 Equus caballus 98.38 0.00e+00 635.00
IUUC-Eeu-035351 Erinaceus europaeus 51.17 9.00e-66 243.00
IUUC-Fca-035630 Felis catus 98.69 0.00e+00 627.00
IUUC-Fal-037646 Ficedula albicollis 73.39 4.00e-112 397.00
IUUC-Fox-037721 Fusarium oxysporum 35.96 7.00e-40 157.00
IUUC-Fso-038379 Fusarium solani 33.67 5.00e-40 157.00
IUUC-Gmo-039616 Gadus morhua 73.20 6.00e-134 470.00
IUUC-Ggr-039727 Gaeumannomyces graminis 31.21 3.00e-30 125.00
IUUC-Gga-040786 Gallus gallus 71.17 2.00e-118 417.00
IUUC-Gac-041971 Gasterosteus aculeatus 79.22 1.00e-150 525.00
IUUC-Gma-043815 Glycine max 38.10 2.00e-42 166.00
IUUC-Ggo-045138 Gorilla gorilla 84.16 2.00e-143 501.00
IUUC-Hsa-045822 Homo sapiens 99.03 0.00e+00 635.00
IUUC-Hvu-047496 Hordeum vulgare 40.40 4.00e-51 194.00
IUUC-Itr-048022 Ictidomys tridecemlineatus 97.05 1.00e-158 551.00
IUUC-Kpa-049334 Komagataella pastoris 37.50 5.00e-32 130.00
IUUC-Lch-050175 Latimeria chalumnae 73.44 1.00e-142 499.00
IUUC-Lpe-051290 Leersia perrieri 39.35 9.00e-50 190.00
IUUC-Loc-052055 Lepisosteus oculatus 86.36 1.00e-165 575.00
IUUC-Lma-053284 Leptosphaeria maculans 38.30 2.00e-38 152.00
IUUC-Laf-053677 Loxodonta africana 97.05 6.00e-179 619.00
IUUC-Mcc-055371 Macaca mulatta 93.09 3.00e-167 580.00
IUUC-Meu-056786 Macropus eugenii 83.12 1.00e-150 525.00
IUUC-Mor-057062 Magnaporthe oryzae 30.23 1.00e-29 123.00
IUUC-Mpo-057319 Magnaporthe poae 28.90 1.00e-29 124.00
IUUC-Mtr-058159 Medicago truncatula 38.41 7.00e-43 167.00
IUUC-Mla-058998 Melampsora laricipopulina 34.78 2.00e-38 152.00
IUUC-Mga-059715 Meleagris gallopavo 75.08 1.00e-143 501.00
IUUC-Mvi-060498 Microbotryum violaceum 45.20 1.00e-44 173.00
IUUC-Mmr-061604 Microcebus murinus 97.73 0.00e+00 631.00
IUUC-Mdo-062723 Monodelphis domestica 94.43 2.00e-175 607.00
IUUC-Mmu-064423 Mus musculus 91.88 2.00e-168 584.00
IUUC-Mac-064557 Musa acuminata 35.74 3.00e-43 168.00
IUUC-Mpu-065790 Mustela putorius furo 98.70 0.00e+00 634.00
IUUC-Mlu-067323 Myotis lucifugus 97.70 3.00e-180 623.00
IUUC-Nfi-068303 Neosartorya fischeri 38.31 3.00e-34 139.00
IUUC-Ncr-068930 Neurospora crassa 33.58 2.00e-33 135.00
IUUC-Nle-069641 Nomascus leucogenys 98.70 0.00e+00 634.00
IUUC-Opr-070264 Ochotona princeps 50.00 4.00e-52 198.00
IUUC-Ont-072619 Oreochromis niloticus 85.39 4.00e-164 570.00
IUUC-Oan-072871 Ornithorhynchus anatinus 93.83 1.00e-176 612.00
IUUC-Ocu-074116 Oryctolagus cuniculus 51.31 1.00e-91 329.00
IUUC-Oba-075519 Oryza barthii 39.00 2.00e-50 192.00
IUUC-Obr-076026 Oryza brachyantha 39.60 5.00e-51 194.00
IUUC-Ogl-077299 Oryza glaberrima 39.39 1.00e-50 193.00
IUUC-Ogu-078328 Oryza glumaepatula 40.15 2.00e-50 192.00
IUUC-Oin-079058 Oryza indica 39.39 1.00e-50 193.00
IUUC-Olo-080760 Oryza longistaminata 39.76 1.00e-45 176.00
IUUC-Ome-081290 Oryza meridionalis 39.00 2.00e-50 192.00
IUUC-Oni-082116 Oryza nivara 38.94 1.00e-49 190.00
IUUC-Opu-083484 Oryza punctata 40.15 8.00e-50 190.00
IUUC-Oru-085234 Oryza rufipogon 38.94 1.00e-49 190.00
IUUC-Osa-085723 Oryza sativa 39.39 1.00e-50 193.00
IUUC-Ola-087142 Oryzias latipes 85.71 1.00e-164 571.00
IUUC-Olu-087663 Ostreococcus lucimarinus 39.19 3.00e-51 195.00
IUUC-Oga-088511 Otolemur garnettii 98.03 1.00e-180 625.00
IUUC-Oar-090337 Ovis aries 73.86 8.00e-122 429.00
IUUC-Ptr-090829 Pan troglodytes 98.68 1.00e-179 621.00
IUUC-Pan-091853 Papio anubis 98.49 2.00e-156 545.00
IUUC-Psi-093244 Pelodiscus sinensis 92.61 8.00e-143 499.00
IUUC-Pno-094768 Phaeosphaeria nodorum 37.63 3.00e-43 169.00
IUUC-Ppa-095402 Physcomitrella patens 36.19 2.00e-48 186.00
IUUC-Pfo-096308 Poecilia formosa 85.71 9.00e-165 572.00
IUUC-Pab-098622 Pongo abelii 98.43 3.00e-150 523.00
IUUC-Pop-099770 Populus trichocarpa 38.68 1.00e-45 176.00
IUUC-Pca-100732 Procavia capensis 95.38 2.00e-172 597.00
IUUC-Ppe-102094 Prunus persica 38.12 3.00e-49 188.00
IUUC-Pva-103208 Pteropus vampyrus 98.05 0.00e+00 631.00
IUUC-Pgr-103639 Puccinia graminis 30.12 1.00e-25 110.00
IUUC-Ptt-103851 Puccinia triticina 33.33 4.00e-33 135.00
IUUC-Pte-104134 Pyrenophora teres 42.32 5.00e-42 164.00
IUUC-Pyt-104660 Pyrenophora triticirepentis 43.10 5.00e-42 164.00
IUUC-Rno-104826 Rattus norvegicus 97.73 0.00e+00 630.00
IUUC-Sce-106237 Saccharomyces cerevisiae 32.57 2.00e-27 116.00
IUUC-Sha-107453 Sarcophilus harrisii 94.74 9.00e-175 605.00
IUUC-Sja-107686 Schizosaccharomyces japonicus 41.00 4.00e-47 181.00
IUUC-Spo-108110 Schizosaccharomyces pombe 41.73 7.00e-48 184.00
IUUC-Smo-108765 Selaginella moellendorffii 37.30 5.00e-48 184.00
IUUC-Sit-110416 Setaria italica 39.33 7.00e-51 194.00
IUUC-Sly-111184 Solanum lycopersicum 39.13 2.00e-51 195.00
IUUC-Stu-112187 Solanum tuberosum 38.33 5.00e-51 194.00
IUUC-Sar-113576 Sorex araneus 45.83 2.00e-28 119.00
IUUC-Sbi-114251 Sorghum bicolor 39.00 2.00e-50 192.00
IUUC-Sre-114975 Sporisorium reilianum 42.27 8.00e-57 213.00
IUUC-Ssc-115522 Sus scrofa 98.89 7.00e-160 556.00
IUUC-Tgu-116610 Taeniopygia guttata 72.37 2.00e-136 478.00
IUUC-Tru-118204 Takifugu rubripes 83.28 1.00e-160 559.00
IUUC-Tsy-119153 Tarsius syrichta 44.44 2.00e-76 279.00
IUUC-Tni-119738 Tetraodon nigroviridis 82.85 1.00e-160 558.00
IUUC-Tca-120950 Theobroma cacao 38.29 7.00e-51 194.00
IUUC-Tre-122109 Trichoderma reesei 36.05 2.00e-41 162.00
IUUC-Tvi-122473 Trichoderma virens 36.12 3.00e-42 165.00
IUUC-Tae-123617 Triticum aestivum 40.27 2.00e-51 195.00
IUUC-Tur-126035 Triticum urartu 43.28 6.00e-46 177.00
IUUC-Tme-127040 Tuber melanosporum 31.50 6.00e-35 141.00
IUUC-Tbe-127888 Tupaia belangeri 46.21 2.00e-36 146.00
IUUC-Ttr-128486 Tursiops truncatus 98.70 0.00e+00 634.00
IUUC-Uma-129516 Ustilago maydis 40.27 3.00e-53 201.00
IUUC-Vda-129861 Verticillium dahliae 37.10 1.00e-34 140.00
IUUC-Vpa-130704 Vicugna pacos 45.75 5.00e-81 294.00
IUUC-Vvi-131375 Vitis vinifera 37.85 3.00e-51 195.00
IUUC-Xtr-132795 Xenopus tropicalis 90.58 2.00e-171 594.00
IUUC-Xma-133866 Xiphophorus maculatus 85.39 2.00e-164 571.00
IUUC-Yli-134568 Yarrowia lipolytica 33.23 8.00e-42 164.00
IUUC-Zma-134891 Zea mays 38.83 5.00e-50 191.00
Created Date 25-Jun-2017

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