iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115315

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

FP085546

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000012305.2	ENSSSCT00000013455.2	ENSSSCP00000013095.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-90	304.5	176	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 176  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 260
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 261  DAHEFLIAALDVLHRHCKG----------------DDAGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 333
           *****************22................22335678899999***************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 334  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 420
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 421  TTYISFPLELDMTPFMASSKESRMNgqlqlptnsgndENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 507
           ******************5544444566666666666**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 508  -SEGYLLFYHKQ 518
           .********985 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

VGPPGCSHVN SFKVGENWRQ ELRVIYQCFV WCGTPETRKS KAKSCICHVC GTHLNRLHSC 60
LSCVFFGCFT EKHIHEHAET KQHNLAVDLY YGGIYCFMCK DYVYDKDIEQ IAKEEQGEAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGTCCAC CAGGCTGTTC CCACGTGAAC AGCTTTAAGG TGGGAGAGAA CTGGAGGCAG 60
GAACTGCGGG TCATCTACCA GTGCTTCGTG TGGTGTGGAA CCCCCGAGAC CAGGAAAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.95	8.00e-63	234.00
IUUC-Aml-002084	Ailuropoda melanoleuca	97.90	0.00e+00	1066.00
IUUC-Atr-002653	Amborella trichopoda	37.68	8.00e-95	340.00
IUUC-Apl-003433	Anas platyrhynchos	84.09	0.00e+00	861.00
IUUC-Aca-005347	Anolis carolinensis	79.85	0.00e+00	901.00
IUUC-Aly-006565	Arabidopsis lyrata	35.99	4.00e-73	268.00
IUUC-Ath-007536	Arabidopsis thaliana	36.05	2.00e-73	269.00
IUUC-Ago-007811	Ashbya gossypii	28.65	7.00e-50	191.00
IUUC-Acl-008124	Aspergillus clavatus	30.59	1.00e-54	206.00
IUUC-Afl-008464	Aspergillus flavus	31.86	3.00e-50	192.00
IUUC-Afu-008912	Aspergillus fumigatus	30.25	1.00e-50	194.00
IUUC-Ani-009168	Aspergillus nidulans	30.38	8.00e-53	201.00
IUUC-Ame-011253	Astyanax mexicanus	74.28	0.00e+00	728.00
IUUC-Bgr-012150	Blumeria graminis	29.68	5.00e-47	181.00
IUUC-Bta-013303	Bos taurus	81.11	0.00e+00	892.00
IUUC-Bci-013604	Botrytis cinerea	29.69	6.00e-53	201.00
IUUC-Bdi-014171	Brachypodium distachyon	35.67	2.00e-74	273.00
IUUC-Cja-019954	Callithrix jacchus	90.82	0.00e+00	969.00
IUUC-Cfa-020956	Canis familiaris	99.20	0.00e+00	1047.00
IUUC-Cpo-022014	Cavia porcellus	97.32	0.00e+00	1064.00
IUUC-Csa-023145	Chlorocebus sabaeus	81.49	0.00e+00	894.00
IUUC-Cho-024938	Choloepus hoffmanni	67.18	6.00e-49	187.00
IUUC-Cin-025109	Ciona intestinalis	53.47	6.00e-115	406.00
IUUC-Csv-026214	Ciona savignyi	52.30	8.00e-163	566.00
IUUC-Cne-027085	Cryptococcus neoformans	31.99	2.00e-60	226.00
IUUC-Dre-027433	Danio rerio	80.12	0.00e+00	804.00
IUUC-Dno-029905	Dasypus novemcinctus	98.12	0.00e+00	878.00
IUUC-Dor-030832	Dipodomys ordii	97.41	3.00e-112	398.00
IUUC-Dme-032074	Drosophila melanogaster	49.17	1.00e-131	463.00
IUUC-Ete-033175	Echinops telfairi	64.35	2.00e-169	588.00
IUUC-Eca-033957	Equus caballus	97.32	0.00e+00	1059.00
IUUC-Eeu-034814	Erinaceus europaeus	86.19	2.00e-105	375.00
IUUC-Fca-035768	Felis catus	97.90	0.00e+00	1068.00
IUUC-Fal-037645	Ficedula albicollis	84.03	0.00e+00	846.00
IUUC-Fox-038046	Fusarium oxysporum	30.06	2.00e-53	203.00
IUUC-Fso-038321	Fusarium solani	30.63	2.00e-52	199.00
IUUC-Gmo-038474	Gadus morhua	84.12	3.00e-151	528.00
IUUC-Ggr-040044	Gaeumannomyces graminis	31.72	6.00e-57	214.00
IUUC-Gga-040624	Gallus gallus	82.70	0.00e+00	915.00
IUUC-Gac-042197	Gasterosteus aculeatus	76.91	0.00e+00	835.00
IUUC-Gma-043933	Glycine max	36.69	4.00e-89	321.00
IUUC-Ggo-044925	Gorilla gorilla	97.32	0.00e+00	1062.00
IUUC-Hsa-046521	Homo sapiens	81.49	0.00e+00	895.00
IUUC-Hvu-047739	Hordeum vulgare	37.50	2.00e-68	252.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	80.92	0.00e+00	889.00
IUUC-Kpa-049135	Komagataella pastoris	33.40	2.00e-66	246.00
IUUC-Lch-050537	Latimeria chalumnae	81.68	0.00e+00	897.00
IUUC-Lpe-050969	Leersia perrieri	39.68	8.00e-71	260.00
IUUC-Loc-052765	Lepisosteus oculatus	74.44	0.00e+00	793.00
IUUC-Lma-053105	Leptosphaeria maculans	31.38	1.00e-62	233.00
IUUC-Laf-053947	Loxodonta africana	95.98	0.00e+00	1052.00
IUUC-Mcc-055166	Macaca mulatta	81.49	0.00e+00	894.00
IUUC-Mor-057103	Magnaporthe oryzae	29.51	8.00e-55	207.00
IUUC-Mpo-057621	Magnaporthe poae	31.66	6.00e-55	207.00
IUUC-Mtr-057894	Medicago truncatula	38.13	7.00e-83	301.00
IUUC-Mga-059709	Meleagris gallopavo	84.09	0.00e+00	861.00
IUUC-Mvi-060530	Microbotryum violaceum	32.22	1.00e-56	214.00
IUUC-Mmr-060988	Microcebus murinus	81.11	0.00e+00	893.00
IUUC-Mdo-063065	Monodelphis domestica	82.44	0.00e+00	904.00
IUUC-Mmu-063829	Mus musculus	81.30	0.00e+00	890.00
IUUC-Mpu-066433	Mustela putorius furo	97.51	0.00e+00	1065.00
IUUC-Mlu-067330	Myotis lucifugus	96.37	0.00e+00	1051.00
IUUC-Nfi-068423	Neosartorya fischeri	29.00	9.00e-51	194.00
IUUC-Ncr-068809	Neurospora crassa	30.21	1.00e-55	210.00
IUUC-Nle-069084	Nomascus leucogenys	99.06	0.00e+00	887.00
IUUC-Opr-070469	Ochotona princeps	67.81	4.00e-171	593.00
IUUC-Ont-071961	Oreochromis niloticus	77.67	0.00e+00	842.00
IUUC-Oan-073565	Ornithorhynchus anatinus	77.97	0.00e+00	830.00
IUUC-Ocu-074951	Oryctolagus cuniculus	95.03	0.00e+00	1043.00
IUUC-Oba-075688	Oryza barthii	35.43	5.00e-75	275.00
IUUC-Obr-076652	Oryza brachyantha	39.79	8.00e-73	266.00
IUUC-Ogl-077910	Oryza glaberrima	35.43	3.00e-78	285.00
IUUC-Ogu-078479	Oryza glumaepatula	35.43	3.00e-78	285.00
IUUC-Oin-079697	Oryza indica	37.62	1.00e-72	266.00
IUUC-Olo-080811	Oryza longistaminata	40.35	1.00e-52	199.00
IUUC-Ome-081706	Oryza meridionalis	35.43	8.00e-78	284.00
IUUC-Oni-083070	Oryza nivara	34.82	5.00e-78	285.00
IUUC-Opu-083605	Oryza punctata	38.46	2.00e-65	242.00
IUUC-Oru-084522	Oryza rufipogon	35.43	3.00e-78	285.00
IUUC-Osa-085351	Oryza sativa	37.59	2.00e-73	270.00
IUUC-Ola-086743	Oryzias latipes	76.74	0.00e+00	659.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.61	5.00e-49	187.00
IUUC-Oga-088771	Otolemur garnettii	98.66	0.00e+00	1086.00
IUUC-Oar-089610	Ovis aries	99.20	0.00e+00	1047.00
IUUC-Ptr-090783	Pan troglodytes	82.27	0.00e+00	835.00
IUUC-Pan-092253	Papio anubis	99.20	0.00e+00	1048.00
IUUC-Psi-093670	Pelodiscus sinensis	83.30	0.00e+00	862.00
IUUC-Pma-094323	Petromyzon marinus	64.13	0.00e+00	651.00
IUUC-Pno-095141	Phaeosphaeria nodorum	30.56	2.00e-55	209.00
IUUC-Ppa-095413	Physcomitrella patens	34.22	9.00e-84	304.00
IUUC-Pfo-096473	Poecilia formosa	78.82	0.00e+00	863.00
IUUC-Pab-098324	Pongo abelii	97.32	0.00e+00	1062.00
IUUC-Pop-099558	Populus trichocarpa	35.48	6.00e-88	318.00
IUUC-Pca-100329	Procavia capensis	96.18	0.00e+00	1050.00
IUUC-Ppe-102020	Prunus persica	37.46	6.00e-93	334.00
IUUC-Pva-102721	Pteropus vampyrus	92.16	0.00e+00	987.00
IUUC-Rno-105247	Rattus norvegicus	81.30	0.00e+00	892.00
IUUC-Sha-107538	Sarcophilus harrisii	83.87	4.00e-108	383.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.09	8.00e-64	237.00
IUUC-Spo-108226	Schizosaccharomyces pombe	32.43	1.00e-59	223.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	29.02	4.00e-49	189.00
IUUC-Smo-109310	Selaginella moellendorffii	35.96	4.00e-87	315.00
IUUC-Sit-109716	Setaria italica	35.76	2.00e-78	286.00
IUUC-Sly-111077	Solanum lycopersicum	37.38	9.00e-81	294.00
IUUC-Stu-112203	Solanum tuberosum	38.88	5.00e-76	277.00
IUUC-Sar-113174	Sorex araneus	93.63	0.00e+00	964.00
IUUC-Sbi-114205	Sorghum bicolor	35.74	5.00e-79	288.00
IUUC-Sre-115195	Sporisorium reilianum	27.46	3.00e-52	199.00
IUUC-Tgu-116938	Taeniopygia guttata	82.23	0.00e+00	836.00
IUUC-Tru-117622	Takifugu rubripes	79.96	0.00e+00	878.00
IUUC-Tni-120119	Tetraodon nigroviridis	79.58	0.00e+00	874.00
IUUC-Tre-122139	Trichoderma reesei	31.07	7.00e-53	201.00
IUUC-Tvi-122599	Trichoderma virens	30.46	2.00e-54	206.00
IUUC-Tae-125608	Triticum aestivum	33.64	6.00e-86	311.00
IUUC-Tme-127115	Tuber melanosporum	34.30	2.00e-78	286.00
IUUC-Ttr-129006	Tursiops truncatus	97.66	0.00e+00	1043.00
IUUC-Vda-129829	Verticillium dahliae	33.11	3.00e-35	141.00
IUUC-Vvi-131477	Vitis vinifera	37.12	4.00e-78	285.00
IUUC-Xtr-132444	Xenopus tropicalis	82.25	0.00e+00	911.00
IUUC-Xma-133514	Xiphophorus maculatus	79.96	0.00e+00	877.00
IUUC-Yli-134357	Yarrowia lipolytica	30.02	6.00e-47	181.00
IUUC-Zma-134945	Zea mays	36.23	5.00e-77	281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence