iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023452

Ensembl Protein ID

ENSCSAP00000015711.1

UniProt Accession

A0A0D9S4C2; A0A0D9S4C2_CHLSB

Genbank Protein ID

ENSCSAP00000015711

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01026576

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000002326.1	ENSCSAT00000000343.1	ENSCSAP00000015711.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-13	49.2	435	466
UBD/Beta-Prp	1.50e-43	149.1	203	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 435  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 466
           89999873359*****************9975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 203  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 287
           567778999998888..9***********************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 288  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPSEEGYWQIAAEFEVPKLVQYLEIVPETgRYPVAVAAAGDLM-YLLKAEDS 375
           ***999999********************************************************99************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 376  ARTLLYAHGPPVTCLDVSANQvafgvRGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSG 464
           *****************************************************************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v++   +d+++v+g++++ v +w++++n+
   Q: 465  NIALSLSAHQLGVSAVQM---DDWKIVSGGQEGLVSVWDYRTNQ 505
           **********99999999...*******************9987 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MDDCSLDEFR RRWQEELAQA QAPRKRRRPE AAERWARRPE VVHGRGEQAS GDPALAQGLL 60
EGAGRPPAAR ATWTEGQDVA SRSRSLAREG AGGGEQLVDQ LIRDLNEMND VPFFDIQLPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAACCAAG AAGAACGTGG AGCGCCGGGA GCAGCGAATA TGGATGACTG CAGCCTGGAT 60
GAGTTCCGTC GGCGCTGGCA GGAGGAGCTG GCGCAGGCCC AGGCGCCAAG GAAGCGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

KEGG

csab:103239212

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	88.03	0.00e+00	933.00
IUUC-Apl-003239	Anas platyrhynchos	58.91	0.00e+00	666.00
IUUC-Aca-004756	Anolis carolinensis	57.14	1.00e-126	446.00
IUUC-Ame-011198	Astyanax mexicanus	42.81	3.00e-58	218.00
IUUC-Bta-012430	Bos taurus	55.99	8.00e-156	543.00
IUUC-Cja-019131	Callithrix jacchus	89.61	0.00e+00	1025.00
IUUC-Cfa-021022	Canis familiaris	79.03	0.00e+00	915.00
IUUC-Cpo-021898	Cavia porcellus	77.98	0.00e+00	900.00
IUUC-Cho-024759	Choloepus hoffmanni	75.08	0.00e+00	818.00
IUUC-Dre-028123	Danio rerio	42.28	3.00e-141	495.00
IUUC-Dno-029045	Dasypus novemcinctus	87.31	0.00e+00	826.00
IUUC-Dor-030433	Dipodomys ordii	77.27	0.00e+00	752.00
IUUC-Ete-032465	Echinops telfairi	80.43	0.00e+00	736.00
IUUC-Eca-034134	Equus caballus	87.20	0.00e+00	893.00
IUUC-Eeu-035047	Erinaceus europaeus	76.94	0.00e+00	764.00
IUUC-Fca-036574	Felis catus	87.06	0.00e+00	881.00
IUUC-Fal-037665	Ficedula albicollis	59.08	1.00e-169	589.00
IUUC-Gmo-039137	Gadus morhua	40.31	8.00e-70	257.00
IUUC-Gga-040711	Gallus gallus	58.86	0.00e+00	655.00
IUUC-Gac-041675	Gasterosteus aculeatus	49.47	7.00e-49	186.00
IUUC-Ggo-045331	Gorilla gorilla	97.76	0.00e+00	999.00
IUUC-Hsa-046240	Homo sapiens	96.82	0.00e+00	1109.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.41	0.00e+00	879.00
IUUC-Loc-052631	Lepisosteus oculatus	48.36	3.00e-162	565.00
IUUC-Laf-054127	Loxodonta africana	71.33	1.00e-54	204.00
IUUC-Mcc-055083	Macaca mulatta	99.00	0.00e+00	1122.00
IUUC-Mga-060113	Meleagris gallopavo	61.82	0.00e+00	638.00
IUUC-Mmr-061780	Microcebus murinus	85.14	0.00e+00	914.00
IUUC-Mdo-063066	Monodelphis domestica	58.94	0.00e+00	701.00
IUUC-Mmu-063524	Mus musculus	76.76	0.00e+00	830.00
IUUC-Mpu-066913	Mustela putorius furo	88.12	0.00e+00	914.00
IUUC-Mlu-067924	Myotis lucifugus	84.25	0.00e+00	918.00
IUUC-Nle-069558	Nomascus leucogenys	95.29	0.00e+00	1021.00
IUUC-Opr-070506	Ochotona princeps	85.77	0.00e+00	893.00
IUUC-Ont-071514	Oreochromis niloticus	47.74	2.00e-142	499.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.36	0.00e+00	860.00
IUUC-Ola-087416	Oryzias latipes	44.08	2.00e-145	509.00
IUUC-Oga-088643	Otolemur garnettii	85.95	0.00e+00	928.00
IUUC-Oar-090172	Ovis aries	86.27	0.00e+00	876.00
IUUC-Ptr-090870	Pan troglodytes	97.32	0.00e+00	1118.00
IUUC-Pan-092017	Papio anubis	97.66	0.00e+00	1132.00
IUUC-Psi-093794	Pelodiscus sinensis	63.03	0.00e+00	646.00
IUUC-Pfo-096192	Poecilia formosa	49.71	2.00e-144	506.00
IUUC-Pab-097882	Pongo abelii	95.82	0.00e+00	1085.00
IUUC-Pca-100902	Procavia capensis	84.57	2.00e-153	535.00
IUUC-Pva-103139	Pteropus vampyrus	83.81	0.00e+00	947.00
IUUC-Rno-105798	Rattus norvegicus	79.88	0.00e+00	843.00
IUUC-Sha-106576	Sarcophilus harrisii	64.55	0.00e+00	660.00
IUUC-Ssc-115923	Sus scrofa	76.34	0.00e+00	908.00
IUUC-Tgu-116667	Taeniopygia guttata	52.80	6.00e-107	380.00
IUUC-Tru-118323	Takifugu rubripes	43.08	3.00e-135	475.00
IUUC-Tsy-118818	Tarsius syrichta	70.08	2.00e-96	345.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.33	1.00e-133	469.00
IUUC-Tbe-127784	Tupaia belangeri	82.52	3.00e-96	345.00
IUUC-Ttr-128288	Tursiops truncatus	72.94	0.00e+00	803.00
IUUC-Vpa-130307	Vicugna pacos	77.68	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence