iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090865

UUCD1 version

UUC-PaT-00567

Ensembl Protein ID

ENSPTRP00000028466.3

UniProt Accession

H2QQE8; H2QQE8_PANTR

Genbank Protein ID

JAA08944.1; JAA20038.1; JAA29792.1; JAA44144.1

Protein Name

SH3 domain containing ring finger 1

Genbank Nucleotide ID

AACZ03031387; GABF01002107; GABD01003308; GABE01000595

Gene Name

SH3RF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016587.3	ENSPTRT00000030825.3	ENSPTRP00000028466.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.50e-08	33.2	12	53
UBD/SH3	4.50e-48	161.1	449	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 449  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 504
           5679**********************9.555.569********************988 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV 60
EELPSNILLV RLLDGIKQRP WKPGPGGGSG TNCTNALRSQ SSTVANCSSK DLQSSQGGQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGAGCGGC GAGCGCGGTG GGGCCGCATC TGCATCAGCC GCCGCAGCCG CTGCGGGGCC 60
GCGAACAAAG AGGAGGAGCC GAGGCGCGAG GTAGGGCGCG CGGCCGGCGC GGGGTCGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4

PRINTS

PR00452--SH3DOMAIN

SMART

SM00184--RING
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0046328--P:regulation of JNK cascade

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001528	Ailuropoda melanoleuca	91.13	0.00e+00	1345.00
IUUC-Apl-003961	Anas platyrhynchos	80.52	0.00e+00	1194.00
IUUC-Aca-004386	Anolis carolinensis	76.66	0.00e+00	1178.00
IUUC-Ame-010659	Astyanax mexicanus	72.99	9.00e-149	520.00
IUUC-Bta-012563	Bos taurus	65.43	2.00e-128	452.00
IUUC-Cja-019730	Callithrix jacchus	94.83	0.00e+00	1371.00
IUUC-Cfa-020992	Canis familiaris	91.25	0.00e+00	1384.00
IUUC-Cpo-021304	Cavia porcellus	92.58	0.00e+00	1457.00
IUUC-Csa-023925	Chlorocebus sabaeus	98.87	0.00e+00	1414.00
IUUC-Cho-024630	Choloepus hoffmanni	84.66	0.00e+00	890.00
IUUC-Cin-025274	Ciona intestinalis	48.71	4.00e-71	261.00
IUUC-Csv-026136	Ciona savignyi	41.13	3.00e-71	262.00
IUUC-Dre-028290	Danio rerio	61.46	0.00e+00	898.00
IUUC-Dno-029083	Dasypus novemcinctus	88.41	0.00e+00	1282.00
IUUC-Dor-030388	Dipodomys ordii	94.94	0.00e+00	678.00
IUUC-Dme-032207	Drosophila melanogaster	42.25	1.00e-63	238.00
IUUC-Ete-032809	Echinops telfairi	80.00	0.00e+00	847.00
IUUC-Eca-034185	Equus caballus	92.75	0.00e+00	1117.00
IUUC-Eeu-034816	Erinaceus europaeus	78.05	0.00e+00	1154.00
IUUC-Fca-036439	Felis catus	90.16	0.00e+00	1407.00
IUUC-Fal-037074	Ficedula albicollis	79.17	0.00e+00	1172.00
IUUC-Gmo-039443	Gadus morhua	69.11	8.00e-93	335.00
IUUC-Gga-040749	Gallus gallus	78.72	0.00e+00	1137.00
IUUC-Gac-041420	Gasterosteus aculeatus	73.84	4.00e-148	518.00
IUUC-Ggo-045215	Gorilla gorilla	98.76	0.00e+00	1483.00
IUUC-Hsa-046315	Homo sapiens	99.55	0.00e+00	1487.00
IUUC-Itr-048265	Ictidomys tridecemlineatus	91.27	4.00e-158	550.00
IUUC-Lch-049453	Latimeria chalumnae	69.72	0.00e+00	892.00
IUUC-Laf-053651	Loxodonta africana	90.90	0.00e+00	1321.00
IUUC-Mcc-054688	Macaca mulatta	98.09	0.00e+00	1451.00
IUUC-Meu-056291	Macropus eugenii	75.11	0.00e+00	785.00
IUUC-Mga-059944	Meleagris gallopavo	77.82	0.00e+00	1159.00
IUUC-Mmr-061553	Microcebus murinus	91.78	0.00e+00	1273.00
IUUC-Mdo-062313	Monodelphis domestica	77.77	0.00e+00	1187.00
IUUC-Mmu-063516	Mus musculus	90.49	0.00e+00	1393.00
IUUC-Mpu-066064	Mustela putorius furo	91.33	0.00e+00	1362.00
IUUC-Mlu-067312	Myotis lucifugus	89.74	0.00e+00	1301.00
IUUC-Nle-069035	Nomascus leucogenys	98.31	0.00e+00	1477.00
IUUC-Opr-070690	Ochotona princeps	87.29	0.00e+00	677.00
IUUC-Ont-071484	Oreochromis niloticus	57.86	0.00e+00	858.00
IUUC-Oan-073305	Ornithorhynchus anatinus	82.56	0.00e+00	1229.00
IUUC-Ocu-074936	Oryctolagus cuniculus	91.07	0.00e+00	1392.00
IUUC-Ola-086675	Oryzias latipes	60.59	3.00e-175	608.00
IUUC-Oga-087933	Otolemur garnettii	82.68	0.00e+00	1024.00
IUUC-Oar-090408	Ovis aries	61.22	1.00e-111	397.00
IUUC-Pan-092362	Papio anubis	98.99	0.00e+00	1413.00
IUUC-Psi-093876	Pelodiscus sinensis	79.42	0.00e+00	1210.00
IUUC-Pfo-097116	Poecilia formosa	59.56	0.00e+00	843.00
IUUC-Pab-098127	Pongo abelii	99.44	0.00e+00	1484.00
IUUC-Pca-100485	Procavia capensis	89.23	0.00e+00	1016.00
IUUC-Pva-102661	Pteropus vampyrus	89.75	0.00e+00	1293.00
IUUC-Rno-105728	Rattus norvegicus	89.07	0.00e+00	1377.00
IUUC-Sha-106515	Sarcophilus harrisii	86.00	0.00e+00	862.00
IUUC-Sar-113161	Sorex araneus	96.07	0.00e+00	672.00
IUUC-Ssc-115314	Sus scrofa	77.36	0.00e+00	1091.00
IUUC-Tgu-117012	Taeniopygia guttata	79.73	0.00e+00	1177.00
IUUC-Tru-118467	Takifugu rubripes	60.60	2.00e-159	556.00
IUUC-Tsy-119566	Tarsius syrichta	84.22	2.00e-175	609.00
IUUC-Tni-120830	Tetraodon nigroviridis	59.72	5.00e-167	581.00
IUUC-Tbe-128070	Tupaia belangeri	88.29	0.00e+00	918.00
IUUC-Ttr-128161	Tursiops truncatus	94.51	3.00e-143	502.00
IUUC-Xtr-132628	Xenopus tropicalis	72.45	0.00e+00	1082.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence