iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000124171.8	ENST00000371610.6	ENSP00000360672.2
ENSG00000124171.8	ENST00000396039.1	ENSP00000379354.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	17726178

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	4.80e-22	79.6	16	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           t++vk+++++e+r+f+l+++kpgkfe+++ +++++++++n +v ++Y+D +GDl+++++D++++kavs   ++++llr++iqkk
   Q: 16   TMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVS---TANPLLRIFIQKK 96
           589*****************************************************************...9**********86 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.

Protein Sequence
(Fasta)

MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 60
GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGAGGGA GCTGCTTCCC CGCCTGCCGC GCCACCAGTC CGACCCTCGG TCCCGCCGTG 60
TGAGCAGCTG GTGGAGTGGA GCTCAGCGCG GACGCCGGAG CTGCGGCCGC CCCCTCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0007409--P:axonogenesis
GO:0070830--P:bicellular tight junction assembly
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0007043--P:cell-cell junction assembly
GO:0007163--P:establishment or maintenance of cell polarity
GO:0006461--P:protein complex assembly
GO:0030334--P:regulation of cell migration

KEGG

hsa:84612

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000216	Aegilops tauschii	35.90	1.10e-01	29.60
IUUC-Aml-002050	Ailuropoda melanoleuca	97.04	0.00e+00	687.00
IUUC-Apl-003829	Anas platyrhynchos	80.75	5.00e-157	546.00
IUUC-Aca-004451	Anolis carolinensis	84.78	2.00e-129	454.00
IUUC-Ame-011428	Astyanax mexicanus	80.31	8.00e-120	423.00
IUUC-Bta-013165	Bos taurus	85.25	6.00e-178	616.00
IUUC-Cja-018719	Callithrix jacchus	97.85	0.00e+00	711.00
IUUC-Cfa-020802	Canis familiaris	83.11	1.00e-158	552.00
IUUC-Cpo-021864	Cavia porcellus	96.29	0.00e+00	631.00
IUUC-Csa-023766	Chlorocebus sabaeus	98.39	0.00e+00	697.00
IUUC-Cho-024608	Choloepus hoffmanni	94.09	0.00e+00	679.00
IUUC-Cin-025213	Ciona intestinalis	53.28	1.00e-71	263.00
IUUC-Csv-025825	Ciona savignyi	55.14	2.00e-71	262.00
IUUC-Dre-028158	Danio rerio	80.31	2.00e-116	412.00
IUUC-Dno-030052	Dasypus novemcinctus	96.51	0.00e+00	679.00
IUUC-Dor-030924	Dipodomys ordii	87.63	2.00e-177	615.00
IUUC-Dme-031864	Drosophila melanogaster	62.34	5.00e-74	271.00
IUUC-Ete-032876	Echinops telfairi	79.57	1.00e-151	529.00
IUUC-Eca-033894	Equus caballus	94.86	0.00e+00	639.00
IUUC-Eeu-034442	Erinaceus europaeus	89.78	7.00e-178	616.00
IUUC-Fca-035602	Felis catus	96.29	0.00e+00	634.00
IUUC-Fal-037422	Ficedula albicollis	83.71	3.00e-144	504.00
IUUC-Fso-038312	Fusarium solani	32.61	2.10e+00	27.70
IUUC-Gga-040289	Gallus gallus	83.33	4.00e-156	544.00
IUUC-Gac-041720	Gasterosteus aculeatus	84.52	6.00e-117	414.00
IUUC-Ggo-045502	Gorilla gorilla	100.00	0.00e+00	707.00
IUUC-Itr-048930	Ictidomys tridecemlineatus	95.43	0.00e+00	640.00
IUUC-Lch-050235	Latimeria chalumnae	73.67	3.00e-142	498.00
IUUC-Loc-052534	Lepisosteus oculatus	69.47	3.00e-132	464.00
IUUC-Laf-053439	Loxodonta africana	93.55	0.00e+00	667.00
IUUC-Mcc-054945	Macaca mulatta	97.05	0.00e+00	684.00
IUUC-Meu-056703	Macropus eugenii	89.71	2.00e-172	597.00
IUUC-Mor-057134	Magnaporthe oryzae	32.93	6.70e-02	31.20
IUUC-Mga-059330	Meleagris gallopavo	82.49	1.00e-146	513.00
IUUC-Mmr-060844	Microcebus murinus	97.15	0.00e+00	648.00
IUUC-Mdo-062120	Monodelphis domestica	88.71	0.00e+00	639.00
IUUC-Mmu-064360	Mus musculus	91.40	5.00e-175	607.00
IUUC-Mpu-066914	Mustela putorius furo	96.29	0.00e+00	635.00
IUUC-Mlu-067135	Myotis lucifugus	95.71	0.00e+00	639.00
IUUC-Nle-069266	Nomascus leucogenys	99.73	0.00e+00	707.00
IUUC-Ont-071750	Oreochromis niloticus	81.47	3.00e-123	435.00
IUUC-Oan-073082	Ornithorhynchus anatinus	92.37	5.00e-180	623.00
IUUC-Ocu-074563	Oryctolagus cuniculus	91.15	0.00e+00	632.00
IUUC-Ola-086459	Oryzias latipes	59.80	1.00e-120	426.00
IUUC-Oga-089180	Otolemur garnettii	97.85	0.00e+00	697.00
IUUC-Oar-089284	Ovis aries	87.06	1.00e-161	562.00
IUUC-Ptr-090918	Pan troglodytes	99.73	0.00e+00	701.00
IUUC-Pan-092624	Papio anubis	98.39	0.00e+00	697.00
IUUC-Psi-093544	Pelodiscus sinensis	81.55	4.00e-158	550.00
IUUC-Pfo-097463	Poecilia formosa	80.71	1.00e-118	419.00
IUUC-Pab-097846	Pongo abelii	100.00	0.00e+00	707.00
IUUC-Pva-103173	Pteropus vampyrus	95.43	0.00e+00	672.00
IUUC-Rno-105169	Rattus norvegicus	91.40	0.00e+00	655.00
IUUC-Sha-106608	Sarcophilus harrisii	89.52	0.00e+00	641.00
IUUC-Ssc-115788	Sus scrofa	97.04	0.00e+00	709.00
IUUC-Tgu-117327	Taeniopygia guttata	83.06	2.00e-152	532.00
IUUC-Tru-117906	Takifugu rubripes	78.12	2.00e-115	409.00
IUUC-Tsy-119156	Tarsius syrichta	91.71	1.00e-178	619.00
IUUC-Tae-123026	Triticum aestivum	23.66	1.50e-01	32.70
IUUC-Tbe-127604	Tupaia belangeri	92.00	3.00e-174	603.00
IUUC-Ttr-128716	Tursiops truncatus	97.58	0.00e+00	691.00
IUUC-Vpa-130278	Vicugna pacos	96.24	0.00e+00	689.00
IUUC-Xtr-132550	Xenopus tropicalis	75.46	2.00e-142	499.00
IUUC-Xma-133768	Xiphophorus maculatus	81.08	1.00e-121	429.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence