iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067000

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02019136

Gene Name

RBCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000009983.2	ENSMLUT00000009979.2	ENSMLUP00000009099.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.90e-11	42.7	194	220
ULD/UDP/UBQ/UBQ_Other	1.30e-07	31.5	59	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C+ CTf+N+P +++CemC+r R+
   Q: 194  VGWQCPGCTFINKPTRPGCEMCCRARP 220
           68************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           v v++++  + t++  v p++tVa LK++++   g+pp+ q++++ G+ L +d  tL ++g++
   Q: 59   VSVEDAQLHTVTIWltVRPDMTVASLKDMVFLDYGFPPALQQWVI-GQRLaRDQETLHSHGVR 120
           67888888888888999****************************.55555*********995 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

VSEKTSQTEE MALRLSRAVA GGDEQVAMEC ATWLAEQRVP LRVQLKPEIS PTQDIRLWVS 60
VEDAQLHTVT IWLTVRPDMT VASLKDMVFL DYGFPPALQQ WVIGQRLARD QETLHSHGVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATCAGAGA AGACTTCCCA GAGAAAGGTG TTTTTTTTGT TTTTTGGTTT TTTTAAAAAT 60
ATATTTTATT GATTTTTTAC AGAGAGGAAG GGAGAGGGAT AGAGAGTTAG AAACATTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	89.22	0.00e+00	839.00
IUUC-Apl-003627	Anas platyrhynchos	54.55	3.00e-16	76.30
IUUC-Aca-004507	Anolis carolinensis	63.44	7.00e-153	533.00
IUUC-Ame-011008	Astyanax mexicanus	51.87	2.00e-140	492.00
IUUC-Bta-013247	Bos taurus	90.59	0.00e+00	880.00
IUUC-Bci-013637	Botrytis cinerea	24.88	2.00e-12	68.20
IUUC-Cja-018880	Callithrix jacchus	90.59	0.00e+00	877.00
IUUC-Cfa-020477	Canis familiaris	91.18	0.00e+00	883.00
IUUC-Cpo-021558	Cavia porcellus	87.25	0.00e+00	837.00
IUUC-Csa-024129	Chlorocebus sabaeus	90.39	0.00e+00	842.00
IUUC-Cin-025630	Ciona intestinalis	39.34	1.00e-82	300.00
IUUC-Csv-026069	Ciona savignyi	51.20	4.00e-73	267.00
IUUC-Dre-027591	Danio rerio	51.05	7.00e-141	493.00
IUUC-Dno-029015	Dasypus novemcinctus	89.41	0.00e+00	844.00
IUUC-Dor-030313	Dipodomys ordii	82.24	0.00e+00	733.00
IUUC-Ete-032908	Echinops telfairi	78.80	0.00e+00	737.00
IUUC-Eca-034295	Equus caballus	76.89	0.00e+00	722.00
IUUC-Eeu-034454	Erinaceus europaeus	81.69	2.00e-110	392.00
IUUC-Fca-036380	Felis catus	91.76	0.00e+00	884.00
IUUC-Fal-037440	Ficedula albicollis	56.90	2.00e-15	73.20
IUUC-Gmo-038561	Gadus morhua	53.76	7.00e-118	417.00
IUUC-Gga-040198	Gallus gallus	40.31	3.00e-29	122.00
IUUC-Gac-041319	Gasterosteus aculeatus	51.95	5.00e-138	484.00
IUUC-Ggo-044456	Gorilla gorilla	63.65	1.00e-148	520.00
IUUC-Hsa-045738	Homo sapiens	91.37	0.00e+00	842.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	90.18	0.00e+00	847.00
IUUC-Lch-050269	Latimeria chalumnae	45.57	2.00e-115	409.00
IUUC-Loc-052776	Lepisosteus oculatus	50.55	5.00e-137	481.00
IUUC-Laf-054269	Loxodonta africana	88.95	0.00e+00	857.00
IUUC-Mcc-055669	Macaca mulatta	90.98	0.00e+00	853.00
IUUC-Mga-059615	Meleagris gallopavo	54.69	3.00e-17	79.70
IUUC-Mmr-061562	Microcebus murinus	91.15	0.00e+00	763.00
IUUC-Mdo-062263	Monodelphis domestica	77.26	0.00e+00	749.00
IUUC-Mmu-064325	Mus musculus	89.39	0.00e+00	836.00
IUUC-Mpu-066385	Mustela putorius furo	90.98	0.00e+00	877.00
IUUC-Nle-069812	Nomascus leucogenys	90.59	0.00e+00	846.00
IUUC-Opr-070575	Ochotona princeps	95.10	8.00e-107	380.00
IUUC-Ont-072405	Oreochromis niloticus	49.03	2.00e-133	469.00
IUUC-Ocu-074358	Oryctolagus cuniculus	79.62	0.00e+00	749.00
IUUC-Ola-086403	Oryzias latipes	52.08	2.00e-137	482.00
IUUC-Oga-087986	Otolemur garnettii	90.00	0.00e+00	827.00
IUUC-Oar-089600	Ovis aries	88.63	0.00e+00	872.00
IUUC-Ptr-091224	Pan troglodytes	91.18	0.00e+00	841.00
IUUC-Pan-092739	Papio anubis	91.18	0.00e+00	856.00
IUUC-Pma-094407	Petromyzon marinus	46.97	9.00e-127	447.00
IUUC-Pfo-097161	Poecilia formosa	51.36	3.00e-132	465.00
IUUC-Pab-098627	Pongo abelii	91.18	0.00e+00	835.00
IUUC-Pca-100641	Procavia capensis	88.89	0.00e+00	798.00
IUUC-Pva-102670	Pteropus vampyrus	91.37	0.00e+00	853.00
IUUC-Pte-104234	Pyrenophora teres	25.41	1.00e-11	64.70
IUUC-Rno-105504	Rattus norvegicus	88.41	0.00e+00	827.00
IUUC-Sha-107342	Sarcophilus harrisii	76.36	0.00e+00	759.00
IUUC-Sar-113425	Sorex araneus	89.04	7.00e-114	404.00
IUUC-Ssc-115904	Sus scrofa	93.06	1.00e-89	321.00
IUUC-Tru-117607	Takifugu rubripes	51.41	1.00e-129	456.00
IUUC-Tni-119873	Tetraodon nigroviridis	50.00	2.00e-137	482.00
IUUC-Tbe-127578	Tupaia belangeri	89.57	0.00e+00	677.00
IUUC-Ttr-129107	Tursiops truncatus	90.78	0.00e+00	835.00
IUUC-Vpa-130353	Vicugna pacos	92.31	2.00e-119	421.00
IUUC-Xtr-132168	Xenopus tropicalis	42.69	5.00e-94	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence