iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013411

UUCD1 version

UUC-BoT-00559

Ensembl Protein ID

ENSBTAP00000005753.4

UniProt Accession

F1MSN0; F1MSN0_BOVIN

Genbank Protein ID

AFP96994.1; DAA15735.1

Protein Name

Suppressor of cytokine signaling 1; Suppressor of cytokine signaling 1-like

Genbank Nucleotide ID

DAAA02057473; GJ062847

Gene Name

SOCS1; BOS_22643

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004386.4	ENSBTAT00000005753.4	ENSBTAP00000005753.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.90e-13	50.2	175	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 175  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 222
           6789*************************...***************9986 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MVAHNQVAAD NAISTAAEPR RRPESSSSSS SSSSSTSSPS SAAPARLRPC PAAAAPAPAP 60
APGDTHFRTF RSHAEYRRIT RASALLDACG FYWGPLSVHG AHERLRAEPV GTFLVRDSRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAATCT CCACGGCAGC AGAGCCCAGA 60
CGGCGGCCAG AGTCTTCTTC CTCCTCCTCC TCCTCCTCCT CTTCCACCTC CTCGCCCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

bta:518795

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	92.50	6.00e-80	289.00
IUUC-Apl-003313	Anas platyrhynchos	59.03	4.00e-73	266.00
IUUC-Aca-005109	Anolis carolinensis	67.72	3.00e-62	231.00
IUUC-Ame-011550	Astyanax mexicanus	49.38	3.00e-48	184.00
IUUC-Cja-019595	Callithrix jacchus	87.89	1.00e-93	335.00
IUUC-Cfa-020563	Canis familiaris	98.14	1.00e-91	328.00
IUUC-Cpo-021374	Cavia porcellus	88.79	3.00e-94	337.00
IUUC-Csa-023333	Chlorocebus sabaeus	88.34	1.00e-93	335.00
IUUC-Dre-028507	Danio rerio	46.15	5.00e-44	170.00
IUUC-Dno-029406	Dasypus novemcinctus	85.20	2.00e-92	331.00
IUUC-Ete-032399	Echinops telfairi	87.44	3.00e-92	330.00
IUUC-Eca-033519	Equus caballus	82.51	4.00e-88	316.00
IUUC-Fal-036726	Ficedula albicollis	57.85	4.00e-73	267.00
IUUC-Gmo-039667	Gadus morhua	50.44	1.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	59.56	8.00e-73	266.00
IUUC-Gac-041838	Gasterosteus aculeatus	44.38	4.00e-35	140.00
IUUC-Ggo-045569	Gorilla gorilla	79.37	3.00e-94	337.00
IUUC-Hsa-046010	Homo sapiens	87.89	2.00e-92	331.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	99.38	5.00e-93	333.00
IUUC-Lch-050219	Latimeria chalumnae	62.03	6.00e-62	229.00
IUUC-Loc-052494	Lepisosteus oculatus	57.23	2.00e-54	204.00
IUUC-Laf-054219	Loxodonta africana	96.32	7.00e-72	262.00
IUUC-Mcc-054830	Macaca mulatta	88.79	2.00e-93	335.00
IUUC-Meu-056565	Macropus eugenii	70.40	5.00e-81	293.00
IUUC-Mga-060153	Meleagris gallopavo	58.59	2.00e-72	264.00
IUUC-Mmr-061365	Microcebus murinus	88.79	4.00e-92	330.00
IUUC-Mdo-062824	Monodelphis domestica	69.06	4.00e-79	286.00
IUUC-Mmu-064120	Mus musculus	96.89	2.00e-90	324.00
IUUC-Mpu-066839	Mustela putorius furo	89.69	5.00e-94	336.00
IUUC-Mlu-067829	Myotis lucifugus	96.89	4.00e-90	323.00
IUUC-Nle-069592	Nomascus leucogenys	82.96	8.00e-89	319.00
IUUC-Ont-072173	Oreochromis niloticus	44.38	3.00e-37	148.00
IUUC-Oan-073586	Ornithorhynchus anatinus	55.14	1.00e-26	112.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.14	3.00e-92	330.00
IUUC-Oba-075150	Oryza barthii	30.59	2.60e-02	31.60
IUUC-Ola-087158	Oryzias latipes	45.62	6.00e-39	153.00
IUUC-Oga-088076	Otolemur garnettii	84.75	4.00e-92	330.00
IUUC-Ptr-091241	Pan troglodytes	88.34	6.00e-94	336.00
IUUC-Pan-091836	Papio anubis	79.37	8.00e-94	335.00
IUUC-Psi-093628	Pelodiscus sinensis	62.78	8.00e-76	276.00
IUUC-Pfo-097501	Poecilia formosa	44.65	3.00e-36	144.00
IUUC-Pab-098170	Pongo abelii	87.89	2.00e-92	331.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.30e-02	33.50
IUUC-Pva-102796	Pteropus vampyrus	88.79	5.00e-93	333.00
IUUC-Rno-105319	Rattus norvegicus	96.89	2.00e-90	324.00
IUUC-Sha-107201	Sarcophilus harrisii	80.52	7.00e-74	268.00
IUUC-Ssc-116004	Sus scrofa	91.93	5.00e-100	356.00
IUUC-Tgu-116836	Taeniopygia guttata	59.91	4.00e-74	270.00
IUUC-Tru-118090	Takifugu rubripes	42.50	2.00e-35	142.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.12	2.00e-31	128.00
IUUC-Vpa-130235	Vicugna pacos	89.69	1.00e-92	331.00
IUUC-Xtr-132610	Xenopus tropicalis	53.81	5.00e-67	246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence