iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044677

UUCD1 version

UUC-GoG-00789

Ensembl Protein ID

ENSGGOP00000020816.1

UniProt Accession

G3RYC9; G3RYC9_GORGO

Protein Name

Uncharacterized protein

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000026552.1	ENSGGOT00000026268.1	ENSGGOP00000020816.1
ENSGGOG00000026552.1	ENSGGOT00000032938.1	ENSGGOP00000027657.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-124	414.8	2159	2617

Active Site

Position(s)	Description	Evidence
2586	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   glk+p                     
   Q: 2159 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2244
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2245 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2331
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2332 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLN 2418
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2419 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---Q 2501
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2502 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2588
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2589 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2617
           ***********************.****86 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGACCCAGA TACATTGCTG GAATGGCTAC AGATGGGACA GGGAGATGAA 60
AGGGACATGC AACTAATAGC CCTTGAACAG CTATGCATGC TGCTTTTGAT GTCTGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	94.99	0.00e+00	4413.00
IUUC-Apl-003493	Anas platyrhynchos	91.21	0.00e+00	4256.00
IUUC-Aca-004521	Anolis carolinensis	92.30	0.00e+00	2646.00
IUUC-Ame-011258	Astyanax mexicanus	86.23	0.00e+00	2222.00
IUUC-Bta-012835	Bos taurus	95.03	0.00e+00	4428.00
IUUC-Cel-018153	Caenorhabditis elegans	47.77	1.00e-161	565.00
IUUC-Cja-019174	Callithrix jacchus	95.27	0.00e+00	4406.00
IUUC-Cfa-021115	Canis familiaris	94.88	0.00e+00	4370.00
IUUC-Cpo-022382	Cavia porcellus	91.78	0.00e+00	4224.00
IUUC-Csa-023230	Chlorocebus sabaeus	95.38	0.00e+00	4433.00
IUUC-Cho-024711	Choloepus hoffmanni	92.00	0.00e+00	1556.00
IUUC-Cin-025342	Ciona intestinalis	50.11	0.00e+00	1261.00
IUUC-Csv-026031	Ciona savignyi	48.73	0.00e+00	1288.00
IUUC-Dre-027435	Danio rerio	83.26	0.00e+00	3870.00
IUUC-Dno-029954	Dasypus novemcinctus	94.84	0.00e+00	4380.00
IUUC-Dor-030734	Dipodomys ordii	92.79	0.00e+00	1383.00
IUUC-Dme-031739	Drosophila melanogaster	56.86	0.00e+00	1523.00
IUUC-Ete-033192	Echinops telfairi	98.18	0.00e+00	703.00
IUUC-Eca-033434	Equus caballus	95.35	0.00e+00	4429.00
IUUC-Eeu-035031	Erinaceus europaeus	83.64	5.00e-170	591.00
IUUC-Fca-035998	Felis catus	93.43	0.00e+00	4306.00
IUUC-Fal-037468	Ficedula albicollis	91.30	0.00e+00	2652.00
IUUC-Gmo-038495	Gadus morhua	84.67	0.00e+00	1254.00
IUUC-Gga-040736	Gallus gallus	93.13	0.00e+00	2661.00
IUUC-Gac-041777	Gasterosteus aculeatus	87.10	0.00e+00	2263.00
IUUC-Hsa-045879	Homo sapiens	95.38	0.00e+00	4433.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	95.11	0.00e+00	4425.00
IUUC-Lch-050444	Latimeria chalumnae	87.75	0.00e+00	3950.00
IUUC-Loc-051986	Lepisosteus oculatus	84.12	0.00e+00	3911.00
IUUC-Laf-054230	Loxodonta africana	94.78	0.00e+00	4342.00
IUUC-Mcc-054787	Macaca mulatta	95.38	0.00e+00	4433.00
IUUC-Meu-056502	Macropus eugenii	89.16	0.00e+00	1333.00
IUUC-Mga-059409	Meleagris gallopavo	87.96	0.00e+00	1985.00
IUUC-Mmr-061667	Microcebus murinus	95.13	0.00e+00	4412.00
IUUC-Mdo-061960	Monodelphis domestica	93.36	0.00e+00	4346.00
IUUC-Mmu-063941	Mus musculus	94.21	0.00e+00	4373.00
IUUC-Mpu-065939	Mustela putorius furo	95.03	0.00e+00	4422.00
IUUC-Mlu-068112	Myotis lucifugus	94.65	0.00e+00	4376.00
IUUC-Nle-069001	Nomascus leucogenys	95.30	0.00e+00	4429.00
IUUC-Opr-071222	Ochotona princeps	89.38	0.00e+00	1966.00
IUUC-Ont-072101	Oreochromis niloticus	77.91	0.00e+00	3692.00
IUUC-Oan-072814	Ornithorhynchus anatinus	93.16	0.00e+00	4316.00
IUUC-Ocu-074011	Oryctolagus cuniculus	95.11	0.00e+00	4418.00
IUUC-Ola-086412	Oryzias latipes	86.75	0.00e+00	2245.00
IUUC-Oar-089668	Ovis aries	95.11	0.00e+00	4422.00
IUUC-Ptr-090517	Pan troglodytes	95.72	0.00e+00	4422.00
IUUC-Pan-091849	Papio anubis	92.66	0.00e+00	4252.00
IUUC-Psi-093390	Pelodiscus sinensis	90.03	0.00e+00	2563.00
IUUC-Pma-094628	Petromyzon marinus	77.40	0.00e+00	1435.00
IUUC-Pfo-097075	Poecilia formosa	87.29	0.00e+00	2288.00
IUUC-Pab-098176	Pongo abelii	95.38	0.00e+00	4433.00
IUUC-Pca-101123	Procavia capensis	91.12	0.00e+00	2390.00
IUUC-Pva-103008	Pteropus vampyrus	90.71	0.00e+00	1800.00
IUUC-Rno-105885	Rattus norvegicus	94.42	0.00e+00	4383.00
IUUC-Sha-107048	Sarcophilus harrisii	91.64	0.00e+00	4256.00
IUUC-Sar-113071	Sorex araneus	87.71	0.00e+00	1164.00
IUUC-Ssc-115963	Sus scrofa	94.73	0.00e+00	4401.00
IUUC-Tgu-117167	Taeniopygia guttata	91.17	0.00e+00	2536.00
IUUC-Tru-118626	Takifugu rubripes	88.10	0.00e+00	2335.00
IUUC-Tsy-119504	Tarsius syrichta	93.94	0.00e+00	2212.00
IUUC-Tni-119877	Tetraodon nigroviridis	87.27	0.00e+00	2271.00
IUUC-Tbe-127602	Tupaia belangeri	88.40	0.00e+00	879.00
IUUC-Ttr-128394	Tursiops truncatus	95.68	0.00e+00	3031.00
IUUC-Vpa-130280	Vicugna pacos	94.51	0.00e+00	4210.00
IUUC-Xtr-131787	Xenopus tropicalis	82.51	0.00e+00	2435.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence