iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.00e-47	161.5	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+ktkgDGnC++rA+++s                                                          ll+vf+d+s sd
   Q: 41   SIRKTKGDGNCFYRALGYSylesllgkgreilkfkervlqtpndllaagfeehkfrnffnafysvvelvekdssvssLLKVFNDQSSSD 129
           699************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a  +++++i+aL+q+L+++++v++vd++++    +l++++fpe++ +
   Q: 130  RIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMAMeCDHVQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-T 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSETSFNLIS EKCDILSILR DHPENRIYQR KIQELSKRFT SIRKTKGDGN CFYRALGYSY 60
LESLLGKGRE ILKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDSSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCCGTGCG TCTTGCTGGG ACACAGTGGA GGTCTGCGCT CCGGTCTGAG GGGCGGTCGG 60
GTGTATTCTG CACTCACCCC ACACCCGCGA GGCCCGCGCC GCCCGACCCA ACGGCGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

rno:314405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	96.55	7.00e-134	469.00
IUUC-Bta-012766	Bos taurus	96.15	1.00e-133	468.00
IUUC-Cja-019480	Callithrix jacchus	94.02	2.00e-131	461.00
IUUC-Cfa-021106	Canis familiaris	96.55	2.00e-133	468.00
IUUC-Cpo-022187	Cavia porcellus	94.85	7.00e-132	462.00
IUUC-Csa-023493	Chlorocebus sabaeus	94.85	2.00e-131	461.00
IUUC-Cho-024411	Choloepus hoffmanni	77.07	5.00e-86	310.00
IUUC-Dno-029346	Dasypus novemcinctus	96.14	2.00e-133	468.00
IUUC-Dor-031012	Dipodomys ordii	96.14	5.00e-134	469.00
IUUC-Ete-032266	Echinops telfairi	85.78	1.00e-118	418.00
IUUC-Eca-033356	Equus caballus	96.55	8.00e-133	465.00
IUUC-Eeu-034775	Erinaceus europaeus	95.69	3.00e-132	463.00
IUUC-Fca-035363	Felis catus	94.83	2.00e-131	461.00
IUUC-Ggo-045023	Gorilla gorilla	94.44	1.00e-131	461.00
IUUC-Hsa-046984	Homo sapiens	94.87	3.00e-132	463.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	95.30	2.00e-133	467.00
IUUC-Lch-050514	Latimeria chalumnae	61.23	6.00e-84	303.00
IUUC-Loc-052003	Lepisosteus oculatus	50.90	1.00e-64	239.00
IUUC-Laf-054382	Loxodonta africana	95.26	6.00e-132	462.00
IUUC-Mcc-055516	Macaca mulatta	94.85	1.00e-131	461.00
IUUC-Meu-056038	Macropus eugenii	87.83	1.00e-98	352.00
IUUC-Mmr-060918	Microcebus murinus	96.58	6.00e-135	473.00
IUUC-Mdo-062638	Monodelphis domestica	89.70	2.00e-124	437.00
IUUC-Mmu-063973	Mus musculus	99.14	5.00e-136	477.00
IUUC-Mpu-066013	Mustela putorius furo	95.69	8.00e-133	465.00
IUUC-Mlu-067509	Myotis lucifugus	93.97	2.00e-129	454.00
IUUC-Nle-069673	Nomascus leucogenys	94.87	3.00e-132	463.00
IUUC-Opr-070761	Ochotona princeps	89.16	1.00e-82	298.00
IUUC-Oan-072922	Ornithorhynchus anatinus	84.28	9.00e-115	405.00
IUUC-Ocu-074643	Oryctolagus cuniculus	95.73	3.00e-134	470.00
IUUC-Oni-082026	Oryza nivara	28.76	1.00e-15	78.20
IUUC-Oru-084761	Oryza rufipogon	28.76	1.00e-15	78.20
IUUC-Ola-086603	Oryzias latipes	45.83	3.00e-52	197.00
IUUC-Oga-088936	Otolemur garnettii	96.14	4.00e-134	469.00
IUUC-Oar-089460	Ovis aries	96.57	4.00e-133	467.00
IUUC-Ptr-090805	Pan troglodytes	94.44	7.00e-132	462.00
IUUC-Pan-091969	Papio anubis	94.87	3.00e-132	463.00
IUUC-Pab-098476	Pongo abelii	94.42	9.00e-131	458.00
IUUC-Pca-100252	Procavia capensis	90.10	3.00e-53	201.00
IUUC-Pva-102204	Pteropus vampyrus	95.30	9.00e-134	468.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.60e-02	31.20
IUUC-Sha-106968	Sarcophilus harrisii	89.96	1.00e-122	432.00
IUUC-Sar-113295	Sorex araneus	96.12	4.00e-131	459.00
IUUC-Ssc-115288	Sus scrofa	96.14	2.00e-133	467.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.83	1.00e-43	169.00
IUUC-Tbe-127717	Tupaia belangeri	95.95	8.00e-79	285.00
IUUC-Ttr-128221	Tursiops truncatus	77.68	1.00e-101	362.00
IUUC-Uma-129443	Ustilago maydis	33.65	2.00e-24	106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence