iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012574

UUCD1 version

UUC-BoT-00588

Ensembl Protein ID

ENSBTAP00000024658.3

UniProt Accession

Q58DK8; TRI38_BOVIN

Genbank Protein ID

AAX46436.1; AAI04590.1

Protein Name

E3 ubiquitin-protein ligase TRIM38; RING-type E3 ubiquitin transferase TRIM38; Tripartite motif-containing protein 38

Genbank Nucleotide ID

BT021589; BC104589

Gene Name

TRIM38

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018523.5	ENSBTAT00000024658.3	ENSBTAP00000024658.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.20e-08	34.2	8	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk........tcPvtrqplteedlvPnltlrrliq 66
           ee  C+I l lM++ v +++G++y   +I  ++++ ++        +cP +r+p+t  +l Pn+ l +li+
   Q: 8    EEATCSICLHLMTNAVSISCGHSYCHVCIVSFFENLNRmtpglktfSCPQCRAPFTMASLRPNKQLGNLIE 78
           6889*****************************8888889**************************99996 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.

Protein Sequence
(Fasta)

MASKKMREEA TCSICLHLMT NAVSISCGHS YCHVCIVSFF ENLNRMTPGL KTFSCPQCRA 60
PFTMASLRPN KQLGNLIEVI KEMDQEMSCE EHGEKLHLFC EDEGQLICWL CDRGAQHKGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGCCGCCA ATATGTGACT GTCTGCTGTG TGGAGAAGGG ACTGGAAAAG GTCAGACCCA 60
TGTTTTCTCA TGTTTTCTCC ACGGAGGGAT AGGAGACGTG TGTTGGAGGA GGGGATGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0004871--F:signal transducer activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0050687--P:negative regulation of defense response to virus
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0032648--P:regulation of interferon-beta production

KEGG

bta:531022

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001649	Ailuropoda melanoleuca	78.26	0.00e+00	747.00
IUUC-Bci-013692	Botrytis cinerea	29.41	7.00e-08	52.80
IUUC-Cja-019759	Callithrix jacchus	75.43	0.00e+00	671.00
IUUC-Cfa-020431	Canis familiaris	74.73	0.00e+00	701.00
IUUC-Cpo-022541	Cavia porcellus	65.66	0.00e+00	634.00
IUUC-Csa-023320	Chlorocebus sabaeus	75.43	0.00e+00	720.00
IUUC-Cho-024964	Choloepus hoffmanni	72.56	2.00e-132	465.00
IUUC-Dno-029741	Dasypus novemcinctus	67.97	2.00e-180	625.00
IUUC-Dor-030298	Dipodomys ordii	63.45	5.00e-105	374.00
IUUC-Ete-032493	Echinops telfairi	61.82	6.00e-171	593.00
IUUC-Eca-033962	Equus caballus	82.14	0.00e+00	764.00
IUUC-Eeu-035228	Erinaceus europaeus	70.43	2.00e-135	475.00
IUUC-Fca-036349	Felis catus	75.05	0.00e+00	724.00
IUUC-Ggo-044493	Gorilla gorilla	76.74	0.00e+00	735.00
IUUC-Hsa-046161	Homo sapiens	76.30	0.00e+00	733.00
IUUC-Itr-048162	Ictidomys tridecemlineatus	61.18	8.00e-150	523.00
IUUC-Laf-054150	Loxodonta africana	74.51	0.00e+00	694.00
IUUC-Mcc-055076	Macaca mulatta	75.65	0.00e+00	724.00
IUUC-Mmu-063517	Mus musculus	55.51	5.00e-144	504.00
IUUC-Mpu-065752	Mustela putorius furo	76.09	0.00e+00	736.00
IUUC-Mlu-067758	Myotis lucifugus	58.95	3.00e-149	522.00
IUUC-Nle-069117	Nomascus leucogenys	77.34	0.00e+00	741.00
IUUC-Opr-071144	Ochotona princeps	66.96	9.00e-180	622.00
IUUC-Ocu-074825	Oryctolagus cuniculus	69.78	0.00e+00	671.00
IUUC-Oga-088744	Otolemur garnettii	72.41	9.00e-123	432.00
IUUC-Oar-089951	Ovis aries	96.09	0.00e+00	919.00
IUUC-Ptr-090519	Pan troglodytes	76.52	0.00e+00	733.00
IUUC-Pan-092059	Papio anubis	75.65	0.00e+00	726.00
IUUC-Pab-098747	Pongo abelii	77.17	0.00e+00	741.00
IUUC-Pca-100294	Procavia capensis	67.97	0.00e+00	655.00
IUUC-Pva-102129	Pteropus vampyrus	67.76	0.00e+00	662.00
IUUC-Sar-113760	Sorex araneus	65.30	3.00e-165	574.00
IUUC-Tsy-119422	Tarsius syrichta	72.23	0.00e+00	670.00
IUUC-Tbe-127628	Tupaia belangeri	60.92	4.00e-98	350.00
IUUC-Ttr-129039	Tursiops truncatus	88.45	0.00e+00	838.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence