iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-031627

UUCD1 version

UUC-DrM-00637

Ensembl Protein ID

FBpp0070793

UniProt Accession

Q9W462; UBP30_DROME

Genbank Protein ID

AAF46096.1; AAL39794.1; AHN59383.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme 30 homolog; Ubiquitin thioesterase 30 homolog; Ubiquitin-specific-processing protease 30 homolog

Genbank Nucleotide ID

AE014298; AY069649; AE014298

Gene Name

CG3016; Usp30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0029819	FBtr0070828	FBpp0070793

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.70e-54	183.1	40	549

Active Site

Position(s)	Description	Evidence
48	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
506	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw....kskkkavsprellkalkkeaeefsgyeqqDaqEf 95
           Gl+N+g tC++N +LQ+++++p++   l   ++++ ++       ++l++s+ + +e +     + +   +sp ++l+al+++       e++Da+E+
   Q: 40   GLHNFGLTCFLNTLLQAMAACPQFIAWLQL-YNNASPD------RKSLITSMLNTLEVVNgthaTLRGDPYSPGAVLRALNALGWV-IPQEEHDAHEL 129
           9**************************999.6666655......467888888888877655556777799999999999988885.578******** PP
   S: 96   laflldqleeelkkeknkpkeeeeeedkselsde................................................................ 129
           +++ll  leee    + +p   ++++  ++ +d+                                                                
   Q: 130  FHVLLTCLEEEA--IRPQPLGCLSDALPTDNDDNsslagtatpvggfrsfssmaaglgasqrigdqpnrpssamltdflnmeydestslqrlvrseah 225
           ************..455555555544444444446778889999****************************************************** PP
   S: 130  .......................................................................................aeekkkkknks 140
                                                                                                  + +   +  +s
   Q: 226  tpdspasvcerdgndrlgsvlldavspgtpfgfplvsnpdslatpmlggerssrprlpqsqqqqdeglnrrvssscrslerlhrgpgRVSIWSNMMPS 323
           *********************************************************************9999999999988888875566667777* PP
   S: 141  lisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf 237
            + + Fqg +  qi+c+ c+++s +r+++f +++l++p ++    +sl ++L+++ + e l +   ++c++c++ ++ +k++++ klP +L++h  R 
   Q: 324  QVAHPFQGAMGAQIVCNGCGSKSaVRYDKFDSITLNLPPQRR-TGLSLGHLLSEYITSEDLSD---VKCDSCNETTTHTKSVTFAKLPACLCIHVART 417
           **************************************9995.588***************97...9******************************* PP
   S: 238  sfseeqksrekinkkvefpleLdlspfc.tspeekqke................................kkkYeLiavvvHsGslssGHYvayvkn. 301
            +  + ++  k +++v+fp++L+++p+  ++p  +++                                 k+ Y+L+avvvHsG+++sGH+v+y +  
   Q: 418  VWLPT-GQVCKRKDYVHFPESLSMAPYSfVQPHLNSQAgtpwgstmslyssslpmnngvgggegfgtmfpKNLYRLLAVVVHSGEANSGHFVTYRRGs 514
           99987.6677***************96514555555558999999999999999******************************************95 PP
   S: 302  ..ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
             + ++W++ +D+ V+ev+ +evl+     aY+lfY r
   Q: 515  lrNAHRWYYTSDTIVREVSIDEVLS---VPAYLLFYDR 549
           555666*******************...9*******86 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park).

Protein Sequence
(Fasta)

MESEKILMAA GVTVAAVVGA FVFWGPSGSR LRQRRGQIAG LHNFGLTCFL NTLLQAMAAC 60
PQFIAWLQLY NNASPDRKSL ITSMLNTLEV VNGTHATLRG DPYSPGAVLR ALNALGWVIP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTCTACGT TTACAAATTT AAGCTGTCAA ACTTATGTTT GTTTAATGCT TATAGTAGAA 60
ACATTCACAT GTACAACGAT TCGGTTGAAT TTTAAAATAC TTGATTTTCT CTGCAAATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:1901562--P:response to paraquat
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG3016

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001733	Ailuropoda melanoleuca	33.50	2.00e-22	99.80
IUUC-Apl-003645	Anas platyrhynchos	36.67	2.00e-33	135.00
IUUC-Afu-009119	Aspergillus fumigatus	26.29	3.00e-10	59.70
IUUC-Ame-010896	Astyanax mexicanus	33.77	9.00e-36	143.00
IUUC-Bta-012321	Bos taurus	32.46	1.00e-34	140.00
IUUC-Cel-018308	Caenorhabditis elegans	30.35	2.00e-21	95.90
IUUC-Cja-018826	Callithrix jacchus	33.14	6.00e-37	147.00
IUUC-Cfa-021206	Canis familiaris	31.62	9.00e-36	144.00
IUUC-Cpo-021343	Cavia porcellus	31.88	6.00e-36	144.00
IUUC-Csa-023419	Chlorocebus sabaeus	33.62	6.00e-38	151.00
IUUC-Cho-024475	Choloepus hoffmanni	29.78	2.00e-23	102.00
IUUC-Dre-027563	Danio rerio	30.12	4.00e-35	141.00
IUUC-Dno-029929	Dasypus novemcinctus	33.04	6.00e-37	147.00
IUUC-Dor-030166	Dipodomys ordii	29.57	1.00e-26	114.00
IUUC-Ete-032634	Echinops telfairi	33.56	3.00e-33	135.00
IUUC-Eca-033968	Equus caballus	32.50	4.00e-23	102.00
IUUC-Eeu-035279	Erinaceus europaeus	37.50	7.00e-15	74.30
IUUC-Fca-036525	Felis catus	31.88	3.00e-35	142.00
IUUC-Fal-036606	Ficedula albicollis	33.99	1.00e-23	102.00
IUUC-Gmo-038726	Gadus morhua	32.31	8.00e-37	147.00
IUUC-Gga-040718	Gallus gallus	33.82	4.00e-23	101.00
IUUC-Gac-042645	Gasterosteus aculeatus	31.92	1.00e-34	140.00
IUUC-Ggo-045021	Gorilla gorilla	33.62	5.00e-38	151.00
IUUC-Hsa-045832	Homo sapiens	33.62	5.00e-38	151.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	32.50	6.00e-22	98.20
IUUC-Lch-050662	Latimeria chalumnae	31.59	7.00e-36	144.00
IUUC-Loc-052611	Lepisosteus oculatus	34.02	3.00e-38	152.00
IUUC-Laf-053752	Loxodonta africana	32.00	6.00e-22	97.80
IUUC-Mcc-054892	Macaca mulatta	33.62	6.00e-38	151.00
IUUC-Meu-056673	Macropus eugenii	28.86	8.00e-28	117.00
IUUC-Mla-058908	Melampsora laricipopulina	30.26	2.00e-11	62.40
IUUC-Mga-059543	Meleagris gallopavo	34.78	1.00e-40	159.00
IUUC-Mmr-061534	Microcebus murinus	34.00	9.00e-23	100.00
IUUC-Mdo-062140	Monodelphis domestica	36.57	6.00e-17	81.60
IUUC-Mmu-063673	Mus musculus	33.00	3.00e-22	99.00
IUUC-Mpu-066328	Mustela putorius furo	32.46	5.00e-36	144.00
IUUC-Mlu-067938	Myotis lucifugus	32.17	1.00e-35	143.00
IUUC-Nle-069426	Nomascus leucogenys	33.82	3.00e-38	151.00
IUUC-Opr-070796	Ochotona princeps	33.19	5.00e-25	108.00
IUUC-Ont-072248	Oreochromis niloticus	30.29	1.00e-33	136.00
IUUC-Oan-072916	Ornithorhynchus anatinus	32.25	2.00e-35	143.00
IUUC-Ocu-074459	Oryctolagus cuniculus	32.18	7.00e-22	97.40
IUUC-Ogl-077841	Oryza glaberrima	30.77	6.00e-12	63.90
IUUC-Oin-079824	Oryza indica	33.73	3.00e-12	66.60
IUUC-Oru-085184	Oryza rufipogon	33.73	3.00e-12	67.00
IUUC-Ola-087429	Oryzias latipes	32.13	1.00e-30	127.00
IUUC-Oga-087981	Otolemur garnettii	33.50	2.00e-22	99.80
IUUC-Oar-089927	Ovis aries	32.17	1.00e-34	140.00
IUUC-Ptr-090878	Pan troglodytes	33.62	5.00e-38	151.00
IUUC-Pan-092698	Papio anubis	33.62	6.00e-38	151.00
IUUC-Psi-093451	Pelodiscus sinensis	34.58	1.00e-40	159.00
IUUC-Pfo-096096	Poecilia formosa	32.68	9.00e-34	137.00
IUUC-Pab-098676	Pongo abelii	33.33	9.00e-38	150.00
IUUC-Pca-100418	Procavia capensis	36.15	6.00e-17	81.30
IUUC-Pva-103018	Pteropus vampyrus	33.04	5.00e-34	137.00
IUUC-Ptt-103779	Puccinia triticina	29.61	5.00e-10	59.30
IUUC-Rno-105708	Rattus norvegicus	32.37	4.00e-37	148.00
IUUC-Sha-106971	Sarcophilus harrisii	33.62	9.00e-38	150.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	26.29	4.00e-13	69.30
IUUC-Sit-110442	Setaria italica	25.00	3.00e-15	75.90
IUUC-Ssc-116397	Sus scrofa	34.00	3.00e-22	99.40
IUUC-Tgu-117446	Taeniopygia guttata	32.25	6.00e-39	154.00
IUUC-Tru-118268	Takifugu rubripes	34.60	6.00e-38	151.00
IUUC-Tsy-119484	Tarsius syrichta	53.73	1.00e-14	73.90
IUUC-Tni-119735	Tetraodon nigroviridis	32.75	3.00e-35	142.00
IUUC-Tae-125383	Triticum aestivum	24.30	7.00e-13	68.20
IUUC-Tur-126458	Triticum urartu	26.55	2.00e-15	76.30
IUUC-Tbe-127740	Tupaia belangeri	30.09	1.00e-27	117.00
IUUC-Ttr-129273	Tursiops truncatus	31.98	2.00e-35	142.00
IUUC-Xtr-132374	Xenopus tropicalis	35.02	9.00e-36	144.00
IUUC-Xma-133267	Xiphophorus maculatus	30.88	2.00e-33	136.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence