iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033695

UUCD1 version

UUC-EqC-01000

Ensembl Protein ID

ENSECAP00000002368.1

UniProt Accession

F6YLB4; F6YLB4_HORSE

Protein Name

Uncharacterized protein

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000002621.1	ENSECAT00000003338.1	ENSECAP00000002368.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.40e-51	172.3	64	254

Active Site

Position(s)	Description	Evidence
71	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
74	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
248		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 64   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekrtsvadLLASFNDQSTSD 152
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts +lq+es ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 153  YLVVYLRLLTSGHLQRESTFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 237
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 238  PKVYLLYRPGHYDILYK 254
           ***************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LPGVNCLAYD EAIMAQQDRI QQEIAVQNPL VSERLELSVL YKEYAEDDNI YQQKIKDLHK 60
KYSYIRKTRP DGNCFYRAFG FSHLEALLDD SKELQRFKAV SAKSKEDLVS QGFTEFTIED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCAGGTG TTAACTGTCT TGCCTATGAT GAAGCCATCA TGGCTCAGCA GGACCGAATT 60
CAGCAAGAGG TGAGGGGCTG GGGCCGGCGG CCCTGCTGCA GGGATGCAGA GGCTGGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	98.81	5.00e-148	516.00
IUUC-Apl-003233	Anas platyrhynchos	60.00	4.00e-19	85.50
IUUC-Aca-004648	Anolis carolinensis	87.55	3.00e-133	467.00
IUUC-Aly-005710	Arabidopsis lyrata	42.22	1.00e-51	196.00
IUUC-Ath-007112	Arabidopsis thaliana	42.07	8.00e-51	193.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.40
IUUC-Ame-010662	Astyanax mexicanus	84.52	2.00e-127	448.00
IUUC-Bta-013533	Bos taurus	98.41	5.00e-148	516.00
IUUC-Bol-016100	Brassica oleracea	42.21	4.00e-50	191.00
IUUC-Bra-017705	Brassica rapa	39.29	6.00e-45	174.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	2.00e-40	159.00
IUUC-Cja-019190	Callithrix jacchus	98.81	6.00e-148	516.00
IUUC-Cfa-020430	Canis familiaris	98.82	3.00e-149	520.00
IUUC-Cpo-022355	Cavia porcellus	98.41	4.00e-148	516.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.56	3.00e-46	178.00
IUUC-Csa-023286	Chlorocebus sabaeus	95.40	1.00e-145	508.00
IUUC-Cin-025507	Ciona intestinalis	43.33	1.00e-44	172.00
IUUC-Csv-026273	Ciona savignyi	49.80	3.00e-69	254.00
IUUC-Dre-027843	Danio rerio	81.75	7.00e-124	436.00
IUUC-Dno-029165	Dasypus novemcinctus	97.50	8.00e-116	408.00
IUUC-Dor-030943	Dipodomys ordii	98.41	4.00e-148	516.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	3.00e-78	284.00
IUUC-Ete-032296	Echinops telfairi	94.97	1.00e-87	316.00
IUUC-Fca-036441	Felis catus	98.03	9.00e-148	515.00
IUUC-Gmo-038908	Gadus morhua	81.10	1.00e-123	435.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.05	1.00e-31	131.00
IUUC-Gga-040460	Gallus gallus	82.54	1.00e-126	445.00
IUUC-Gac-042417	Gasterosteus aculeatus	80.40	3.00e-121	427.00
IUUC-Gma-043712	Glycine max	42.01	1.00e-50	192.00
IUUC-Ggo-044552	Gorilla gorilla	98.11	1.00e-90	325.00
IUUC-Hsa-046766	Homo sapiens	98.81	3.00e-148	517.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	98.41	4.00e-148	516.00
IUUC-Lch-050602	Latimeria chalumnae	80.56	7.00e-118	416.00
IUUC-Laf-053705	Loxodonta africana	98.41	4.00e-148	516.00
IUUC-Mcc-055745	Macaca mulatta	92.22	1.00e-144	505.00
IUUC-Meu-056569	Macropus eugenii	83.73	4.00e-123	433.00
IUUC-Mtr-057712	Medicago truncatula	43.12	3.00e-46	178.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	2.00e-15	75.90
IUUC-Mmr-061123	Microcebus murinus	98.12	5.00e-122	430.00
IUUC-Mdo-062613	Monodelphis domestica	87.25	1.00e-113	401.00
IUUC-Mmu-063658	Mus musculus	98.41	4.00e-148	516.00
IUUC-Mac-065274	Musa acuminata	37.60	2.00e-39	156.00
IUUC-Mpu-066172	Mustela putorius furo	98.81	3.00e-148	517.00
IUUC-Mlu-066966	Myotis lucifugus	98.41	1.00e-147	514.00
IUUC-Nle-069519	Nomascus leucogenys	86.10	2.00e-91	328.00
IUUC-Ont-071901	Oreochromis niloticus	82.07	3.00e-124	437.00
IUUC-Ola-087331	Oryzias latipes	79.78	1.00e-84	305.00
IUUC-Oga-088064	Otolemur garnettii	98.81	3.00e-148	517.00
IUUC-Oar-089251	Ovis aries	98.41	1.00e-146	511.00
IUUC-Ptr-091430	Pan troglodytes	98.81	6.00e-148	516.00
IUUC-Psi-093823	Pelodiscus sinensis	88.33	3.00e-133	467.00
IUUC-Pma-094366	Petromyzon marinus	75.00	4.00e-101	360.00
IUUC-Pfo-096734	Poecilia formosa	80.48	5.00e-113	400.00
IUUC-Pab-097919	Pongo abelii	98.59	2.00e-121	427.00
IUUC-Pop-099401	Populus trichocarpa	41.24	3.00e-48	184.00
IUUC-Ppe-101977	Prunus persica	42.38	3.00e-51	195.00
IUUC-Pva-102499	Pteropus vampyrus	98.80	2.00e-147	513.00
IUUC-Rno-105233	Rattus norvegicus	98.41	4.00e-148	516.00
IUUC-Sha-107081	Sarcophilus harrisii	98.02	1.00e-147	515.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	5.00e-49	187.00
IUUC-Ssc-116202	Sus scrofa	98.81	3.00e-148	517.00
IUUC-Tru-117664	Takifugu rubripes	78.38	5.00e-120	423.00
IUUC-Tca-121467	Theobroma cacao	41.54	3.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	96.89	2.00e-91	328.00
IUUC-Ttr-128622	Tursiops truncatus	98.02	1.00e-145	508.00
IUUC-Vvi-131389	Vitis vinifera	43.75	1.00e-52	199.00
IUUC-Xma-134191	Xiphophorus maculatus	80.88	4.00e-114	403.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence