iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118511

UUCD1 version

UUC-TaR-00640

Ensembl Protein ID

ENSTRUP00000030380.1

UniProt Accession

H2U0C1; H2U0C1_TAKRU

Protein Name

Uncharacterized protein

Gene Name

cishb; socs8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012004.1	ENSTRUT00000030497.1	ENSTRUP00000030380.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	43.48	3.00e-30	129.00	IUUC-Hsa-046678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

PPAPPAAWGP SEDYRSITAT FRYLETSGWY WGPTSVSDAQ EALLRKSEGT FLMRDSNHPK 60
HMLTLSVKTC CGPTSVRIEY SRGSFWLDSI AAGQLRTQTF PDVVSLVQHY MTLGHVPQSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCCGCCC CTCCCGCAGC CTGGGGCCCA TCAGAGGACT ACCGCAGCAT CACCGCCACC 60
TTCCGGTATC TGGAAACCTC AGGTATCAGC ATCAAGCCTC TCCTGGTGAA AATAGAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	43.59	1.00e-36	146.00
IUUC-Apl-003484	Anas platyrhynchos	39.41	1.00e-27	115.00
IUUC-Aca-004372	Anolis carolinensis	47.31	3.00e-40	158.00
IUUC-Ame-010787	Astyanax mexicanus	52.13	6.00e-51	193.00
IUUC-Bta-012826	Bos taurus	46.15	5.00e-38	150.00
IUUC-Cja-020004	Callithrix jacchus	44.39	6.00e-36	144.00
IUUC-Cfa-020150	Canis familiaris	44.95	5.00e-36	144.00
IUUC-Cpo-022414	Cavia porcellus	41.18	9.00e-29	119.00
IUUC-Csa-023173	Chlorocebus sabaeus	44.90	8.00e-37	147.00
IUUC-Cho-024471	Choloepus hoffmanni	38.73	2.00e-24	104.00
IUUC-Dre-028606	Danio rerio	50.92	1.00e-39	156.00
IUUC-Dno-028956	Dasypus novemcinctus	45.13	3.00e-37	148.00
IUUC-Dor-030148	Dipodomys ordii	44.79	8.00e-34	136.00
IUUC-Ete-032313	Echinops telfairi	43.94	3.00e-34	138.00
IUUC-Eca-033422	Equus caballus	44.95	3.00e-38	151.00
IUUC-Eeu-034806	Erinaceus europaeus	44.62	2.00e-35	142.00
IUUC-Fca-036374	Felis catus	44.95	1.00e-35	142.00
IUUC-Fal-036801	Ficedula albicollis	45.16	5.00e-39	154.00
IUUC-Gmo-038483	Gadus morhua	48.39	9.00e-43	166.00
IUUC-Gga-040891	Gallus gallus	45.70	2.00e-38	152.00
IUUC-Gac-042147	Gasterosteus aculeatus	51.60	5.00e-42	164.00
IUUC-Ggo-045511	Gorilla gorilla	42.86	9.00e-35	140.00
IUUC-Hsa-046678	Homo sapiens	42.86	6.00e-35	140.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	44.44	6.00e-38	150.00
IUUC-Lch-050555	Latimeria chalumnae	47.03	3.00e-41	161.00
IUUC-Loc-051825	Lepisosteus oculatus	38.80	1.00e-29	122.00
IUUC-Laf-054141	Loxodonta africana	43.88	1.00e-37	149.00
IUUC-Mcc-055401	Macaca mulatta	44.39	6.00e-36	144.00
IUUC-Meu-056592	Macropus eugenii	43.88	6.00e-37	147.00
IUUC-Mga-059515	Meleagris gallopavo	45.70	7.00e-38	150.00
IUUC-Mmr-060848	Microcebus murinus	44.62	4.00e-36	144.00
IUUC-Mdo-062720	Monodelphis domestica	43.88	1.00e-36	146.00
IUUC-Mmu-063348	Mus musculus	43.84	4.00e-36	144.00
IUUC-Mpu-065834	Mustela putorius furo	44.62	5.00e-37	147.00
IUUC-Mlu-067687	Myotis lucifugus	45.60	3.00e-38	151.00
IUUC-Nle-069277	Nomascus leucogenys	43.88	4.00e-35	141.00
IUUC-Opr-071087	Ochotona princeps	41.14	4.00e-29	120.00
IUUC-Ont-071890	Oreochromis niloticus	67.40	1.00e-62	232.00
IUUC-Oan-073672	Ornithorhynchus anatinus	45.26	2.00e-37	149.00
IUUC-Ocu-073875	Oryctolagus cuniculus	44.62	7.00e-37	147.00
IUUC-Ola-087140	Oryzias latipes	58.93	2.00e-38	151.00
IUUC-Oga-087943	Otolemur garnettii	45.13	2.00e-37	149.00
IUUC-Oar-090194	Ovis aries	44.79	7.00e-38	150.00
IUUC-Ptr-090934	Pan troglodytes	42.86	1.00e-34	139.00
IUUC-Pan-092121	Papio anubis	44.39	4.00e-36	144.00
IUUC-Psi-093733	Pelodiscus sinensis	45.16	1.00e-37	149.00
IUUC-Pma-094671	Petromyzon marinus	36.27	2.00e-24	105.00
IUUC-Pfo-096313	Poecilia formosa	59.79	3.00e-60	224.00
IUUC-Pab-098439	Pongo abelii	42.35	9.00e-35	140.00
IUUC-Pca-101010	Procavia capensis	45.13	4.00e-37	147.00
IUUC-Pva-103112	Pteropus vampyrus	45.45	5.00e-37	147.00
IUUC-Rno-105917	Rattus norvegicus	43.08	4.00e-35	141.00
IUUC-Sha-106954	Sarcophilus harrisii	44.39	3.00e-38	151.00
IUUC-Sar-113001	Sorex araneus	44.10	2.00e-37	149.00
IUUC-Ssc-115252	Sus scrofa	40.59	4.00e-28	117.00
IUUC-Tgu-117338	Taeniopygia guttata	45.70	3.00e-40	157.00
IUUC-Tsy-119434	Tarsius syrichta	44.95	7.00e-36	143.00
IUUC-Tni-119837	Tetraodon nigroviridis	50.26	2.00e-40	158.00
IUUC-Tbe-127915	Tupaia belangeri	40.59	6.00e-28	116.00
IUUC-Ttr-128372	Tursiops truncatus	40.59	4.00e-28	117.00
IUUC-Vpa-130443	Vicugna pacos	47.18	3.00e-38	151.00
IUUC-Xtr-131784	Xenopus tropicalis	45.26	2.00e-36	145.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence