iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028578

Ensembl Protein ID

ENSDARP00000043801.4

UniProt Accession

Q6DRC5; A8WFQ9; B0JZK5; USPL1_DANRE

Genbank Protein ID

AAT68152.1; AAI54416.1; AAI59219.1; AAI62319.1

Protein Name

SUMO-specific isopeptidase USPL1; Ubiquitin-specific peptidase-like protein 1

Genbank Nucleotide ID

AY648834; BX548163; BC159218; BC162319

Gene Name

uspl1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000034825.5	ENSDART00000043802.4	ENSDARP00000043801.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/USP	35.46	6.00e-61	234.00	IUUC-Hsa-046927

Active Site

Position(s)	Description	Evidence
364	Nucleophile	ECO:0000250}
592	Proton acceptor	ECO:0000250}

Organism

Danio rerio

Functional Description
(View)

SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for sumo2 and sumo3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.

Protein Sequence
(Fasta)

MNGEGTGIGA PTPALAGFLG KSKDRNASPG NCPWCLAKGQ TNALRFYAVN LKETVLLCTN 60
AVCLYPLVSR SLEEVRASLS KGGCKRSISS LPDISDDSCP PKRPREEKLD VLADVSEPCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGTTGATC GTACGACGGG GAGCATGCAC ATGGAAATGT CTCCTACCGG CGTGCTGGAA 60
TTACCGAAAG TGTGTATAAA ATCCAGTCTG GAGATTCTCC GCATCTGCAC CGGACTCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease

Interpro

IPR028890--Peptidase_C98
IPR028889--USP_dom
IPR033505--USPL1

PROSITE

PS50235--USP_3

Pfam

PF15499--Peptidase_C98

Gene Ontology

GO:0015030--C:Cajal body
GO:0032183--F:SUMO binding
GO:0070140--F:SUMO-specific isopeptidase activity
GO:0030576--P:Cajal body organization
GO:0008283--P:cell proliferation
GO:0016926--P:protein desumoylation

KEGG

dre:445403

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002352	Ailuropoda melanoleuca	35.28	3.00e-63	237.00
IUUC-Apl-003844	Anas platyrhynchos	40.99	3.00e-66	247.00
IUUC-Aca-004352	Anolis carolinensis	37.47	6.00e-63	236.00
IUUC-Ame-011600	Astyanax mexicanus	45.29	6.00e-137	481.00
IUUC-Bta-012500	Bos taurus	39.29	4.00e-58	220.00
IUUC-Cja-019507	Callithrix jacchus	35.46	9.00e-62	232.00
IUUC-Cfa-020417	Canis familiaris	34.64	3.00e-61	230.00
IUUC-Cpo-021840	Cavia porcellus	35.58	3.00e-54	206.00
IUUC-Csa-023677	Chlorocebus sabaeus	34.30	9.00e-62	232.00
IUUC-Cho-024641	Choloepus hoffmanni	36.44	8.00e-20	92.40
IUUC-Csv-026246	Ciona savignyi	29.58	2.00e-27	116.00
IUUC-Dno-029810	Dasypus novemcinctus	33.93	2.00e-58	221.00
IUUC-Dor-030531	Dipodomys ordii	44.23	4.00e-34	140.00
IUUC-Ete-032413	Echinops telfairi	37.93	2.00e-41	164.00
IUUC-Eca-033314	Equus caballus	33.15	6.00e-58	219.00
IUUC-Eeu-034679	Erinaceus europaeus	38.08	1.00e-59	225.00
IUUC-Fca-035550	Felis catus	34.35	1.00e-62	235.00
IUUC-Fal-037362	Ficedula albicollis	39.36	1.00e-58	221.00
IUUC-Gmo-039391	Gadus morhua	47.72	1.00e-74	274.00
IUUC-Gga-040792	Gallus gallus	41.13	3.00e-64	240.00
IUUC-Gac-041961	Gasterosteus aculeatus	48.36	4.00e-76	279.00
IUUC-Ggo-045519	Gorilla gorilla	34.30	3.00e-61	230.00
IUUC-Hsa-046927	Homo sapiens	35.46	2.00e-62	234.00
IUUC-Itr-048559	Ictidomys tridecemlineatus	39.01	2.00e-60	228.00
IUUC-Lch-049826	Latimeria chalumnae	37.18	2.00e-71	264.00
IUUC-Loc-052135	Lepisosteus oculatus	43.09	7.00e-88	319.00
IUUC-Laf-054055	Loxodonta africana	34.02	3.00e-58	220.00
IUUC-Mcc-054907	Macaca mulatta	34.66	3.00e-63	237.00
IUUC-Meu-056740	Macropus eugenii	33.88	1.00e-09	59.30
IUUC-Mga-059291	Meleagris gallopavo	40.78	8.00e-64	239.00
IUUC-Mmr-061451	Microcebus murinus	38.08	9.00e-60	226.00
IUUC-Mdo-062677	Monodelphis domestica	35.28	3.00e-61	231.00
IUUC-Mmu-063317	Mus musculus	35.28	2.00e-59	224.00
IUUC-Mpu-066879	Mustela putorius furo	35.46	3.00e-53	204.00
IUUC-Mlu-068012	Myotis lucifugus	38.82	3.00e-50	194.00
IUUC-Nle-070067	Nomascus leucogenys	34.92	5.00e-63	236.00
IUUC-Opr-070918	Ochotona princeps	35.05	5.00e-30	126.00
IUUC-Ont-072559	Oreochromis niloticus	41.04	3.00e-122	433.00
IUUC-Oan-073530	Ornithorhynchus anatinus	39.29	1.00e-60	228.00
IUUC-Ocu-074949	Oryctolagus cuniculus	39.44	1.00e-59	225.00
IUUC-Ola-086887	Oryzias latipes	43.44	7.00e-110	391.00
IUUC-Oga-087975	Otolemur garnettii	36.42	8.00e-59	222.00
IUUC-Oar-089863	Ovis aries	39.15	8.00e-58	219.00
IUUC-Ptr-091090	Pan troglodytes	34.57	2.00e-63	238.00
IUUC-Pan-092097	Papio anubis	34.56	1.00e-61	232.00
IUUC-Psi-093839	Pelodiscus sinensis	37.22	9.00e-67	249.00
IUUC-Pfo-097323	Poecilia formosa	48.06	2.00e-80	294.00
IUUC-Pab-097559	Pongo abelii	38.74	8.00e-40	159.00
IUUC-Pva-102876	Pteropus vampyrus	38.72	3.00e-59	223.00
IUUC-Rno-105019	Rattus norvegicus	36.16	2.00e-58	221.00
IUUC-Sha-106836	Sarcophilus harrisii	35.90	1.00e-65	245.00
IUUC-Sar-113217	Sorex araneus	37.14	9.00e-56	212.00
IUUC-Ssc-115551	Sus scrofa	43.96	5.00e-21	96.30
IUUC-Tgu-117236	Taeniopygia guttata	37.86	2.00e-53	204.00
IUUC-Tru-118150	Takifugu rubripes	48.08	2.00e-77	283.00
IUUC-Tsy-119095	Tarsius syrichta	35.27	9.00e-42	166.00
IUUC-Tni-120489	Tetraodon nigroviridis	47.14	5.00e-76	277.00
IUUC-Tbe-127419	Tupaia belangeri	36.61	2.00e-58	221.00
IUUC-Ttr-128510	Tursiops truncatus	33.59	2.00e-60	228.00
IUUC-Vpa-130671	Vicugna pacos	33.93	7.00e-58	219.00
IUUC-Xtr-132920	Xenopus tropicalis	30.35	4.00e-72	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence