iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090870

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box and WD repeat domain containing 8

Genbank Nucleotide ID

AACZ03087174

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005503.2	ENSPTRT00000010100.2	ENSPTRP00000009338.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.80e-13	48.3	435	466
UBD/Beta-Prp	3.10e-45	154.6	203	506

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 435  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 466
           89999873359*****************9975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 203  ELEHVPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 287
           67888999***8888..************************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 288  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVAVAAAGDLM-YLLKAEDS 375
           ***999999**********************************************************************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 376  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSG 464
           *****************************************************************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           ++  +l+ h+ +v++v++   +d+++v+g+e++ v +w++++n++
   Q: 465  NIALSLSAHQLRVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 506
           ****************99...********************9875 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS GDPALAQGLL 60
EGAGRPPAAR ATRAEGQDVA SRSRSLAREG AGGGEQLVDQ LIRDLNEMND VPFFDIQLPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACT ACAGCCTGGA TGAGTTCCGT CGGCGCTGGC AGGAGGAGCT GGCGCAGGCC 60
CAGGCGCCGA AGAAGCGGCG ACGGCCCGAG GCTGCCGAGA GGCGGGCTCG GCGGCCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	88.03	0.00e+00	938.00
IUUC-Apl-003239	Anas platyrhynchos	59.09	0.00e+00	676.00
IUUC-Aca-004756	Anolis carolinensis	57.88	3.00e-129	454.00
IUUC-Ame-011198	Astyanax mexicanus	54.30	1.00e-57	216.00
IUUC-Bta-012430	Bos taurus	56.16	4.00e-159	554.00
IUUC-Cja-019131	Callithrix jacchus	90.62	0.00e+00	1036.00
IUUC-Cfa-021022	Canis familiaris	79.03	0.00e+00	926.00
IUUC-Cpo-021898	Cavia porcellus	77.81	0.00e+00	907.00
IUUC-Csa-023452	Chlorocebus sabaeus	97.32	0.00e+00	1143.00
IUUC-Cho-024759	Choloepus hoffmanni	75.75	0.00e+00	827.00
IUUC-Dre-028123	Danio rerio	45.16	1.00e-142	499.00
IUUC-Dno-029045	Dasypus novemcinctus	87.53	0.00e+00	832.00
IUUC-Dor-030433	Dipodomys ordii	77.27	0.00e+00	764.00
IUUC-Ete-032465	Echinops telfairi	79.84	0.00e+00	739.00
IUUC-Eca-034134	Equus caballus	87.40	0.00e+00	900.00
IUUC-Eeu-035047	Erinaceus europaeus	76.94	0.00e+00	768.00
IUUC-Fca-036574	Felis catus	87.70	0.00e+00	883.00
IUUC-Fal-037665	Ficedula albicollis	59.28	4.00e-171	594.00
IUUC-Gmo-039137	Gadus morhua	44.69	1.00e-69	256.00
IUUC-Gga-040711	Gallus gallus	59.21	0.00e+00	664.00
IUUC-Gac-041675	Gasterosteus aculeatus	50.00	4.00e-50	190.00
IUUC-Ggo-045331	Gorilla gorilla	99.19	0.00e+00	1018.00
IUUC-Hsa-046240	Homo sapiens	99.50	0.00e+00	1142.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.41	0.00e+00	884.00
IUUC-Loc-052631	Lepisosteus oculatus	53.17	9.00e-164	570.00
IUUC-Laf-054127	Loxodonta africana	72.73	7.00e-56	208.00
IUUC-Mcc-055083	Macaca mulatta	97.83	0.00e+00	1115.00
IUUC-Mga-060113	Meleagris gallopavo	62.22	0.00e+00	646.00
IUUC-Mmr-061780	Microcebus murinus	85.98	0.00e+00	924.00
IUUC-Mdo-063066	Monodelphis domestica	61.17	0.00e+00	706.00
IUUC-Mmu-063524	Mus musculus	77.26	0.00e+00	840.00
IUUC-Mpu-066913	Mustela putorius furo	88.12	0.00e+00	920.00
IUUC-Mlu-067924	Myotis lucifugus	83.75	0.00e+00	929.00
IUUC-Nle-069558	Nomascus leucogenys	97.38	0.00e+00	1053.00
IUUC-Opr-070506	Ochotona princeps	79.43	0.00e+00	902.00
IUUC-Ont-071514	Oreochromis niloticus	47.94	4.00e-144	504.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.77	0.00e+00	867.00
IUUC-Ola-087416	Oryzias latipes	44.46	1.00e-145	509.00
IUUC-Oga-088643	Otolemur garnettii	86.12	0.00e+00	939.00
IUUC-Oar-090172	Ovis aries	85.98	0.00e+00	887.00
IUUC-Pan-092017	Papio anubis	96.49	0.00e+00	1129.00
IUUC-Psi-093794	Pelodiscus sinensis	63.23	0.00e+00	651.00
IUUC-Pfo-096192	Poecilia formosa	50.10	2.00e-146	513.00
IUUC-Pab-097882	Pongo abelii	98.16	0.00e+00	1115.00
IUUC-Pca-100902	Procavia capensis	83.43	3.00e-154	538.00
IUUC-Pva-103139	Pteropus vampyrus	83.97	0.00e+00	957.00
IUUC-Rno-105798	Rattus norvegicus	80.28	0.00e+00	850.00
IUUC-Sha-106576	Sarcophilus harrisii	64.96	0.00e+00	667.00
IUUC-Ssc-115923	Sus scrofa	77.01	0.00e+00	923.00
IUUC-Tgu-116667	Taeniopygia guttata	53.07	3.00e-108	384.00
IUUC-Tru-118323	Takifugu rubripes	43.74	1.00e-136	479.00
IUUC-Tsy-118818	Tarsius syrichta	70.08	4.00e-97	348.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.65	1.00e-134	473.00
IUUC-Tbe-127784	Tupaia belangeri	83.98	8.00e-98	350.00
IUUC-Ttr-128288	Tursiops truncatus	72.94	0.00e+00	810.00
IUUC-Vpa-130307	Vicugna pacos	78.22	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence