iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037604

Ensembl Protein ID

ENSFALP00000012235.1

UniProt Accession

U3KB31; U3KB31_FICAL

Genbank Protein ID

ENSFALP00000012235

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01012033

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000011721.1	ENSFALT00000012285.1	ENSFALP00000012235.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-136	453.9	694	1025

Active Site

Position(s)	Description	Evidence
995	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+ll
   Q: 694  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLL 780
           57899********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++
   Q: 781  DGFFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYID 862
           *************************************99...6666..7************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r 
   Q: 863  LVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRI 949
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++LqFvTg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP Y+s e l+ekLl+A+e+++gFe
   Q: 950  RLLQFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPLYESFEDLREKLLMAVENAQGFE 1025
           ***************************************************************************8 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MELQPQLWGC AELSLAPASR SHPGWGAALS PFQLAVLQAR RIDVLSTGEK KEESRILRVK 60
VVSGIDLAKK DIFGASDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN EEFYFRVNPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTGTTGAT GAAGTCTGGG TTTTGATCTG TAATAGGCTT GCAGTTCCAC CTAAATAGGC 60
TGAGTCCTCT GAAATGGCAC TGTGAGCTGC AGCTAAGAGA ACATAACCTG TGTAAAGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	89.80	0.00e+00	1607.00
IUUC-Apl-003893	Anas platyrhynchos	94.90	0.00e+00	1731.00
IUUC-Aca-004744	Anolis carolinensis	89.26	0.00e+00	1644.00
IUUC-Acl-008273	Aspergillus clavatus	47.22	2.00e-158	552.00
IUUC-Afu-009103	Aspergillus fumigatus	47.54	9.00e-159	553.00
IUUC-Aor-010053	Aspergillus oryzae	57.38	7.00e-100	356.00
IUUC-Ate-010529	Aspergillus terreus	47.12	9.00e-157	547.00
IUUC-Ame-010810	Astyanax mexicanus	70.28	0.00e+00	1229.00
IUUC-Bta-012679	Bos taurus	91.19	0.00e+00	1519.00
IUUC-Cel-018564	Caenorhabditis elegans	51.38	4.00e-178	617.00
IUUC-Cja-018732	Callithrix jacchus	91.60	0.00e+00	1724.00
IUUC-Cfa-021226	Canis familiaris	91.81	0.00e+00	1701.00
IUUC-Cpo-021671	Cavia porcellus	90.17	0.00e+00	1650.00
IUUC-Csa-023344	Chlorocebus sabaeus	92.80	0.00e+00	1754.00
IUUC-Cho-024832	Choloepus hoffmanni	98.58	0.00e+00	735.00
IUUC-Csv-026098	Ciona savignyi	56.80	0.00e+00	644.00
IUUC-Dre-027770	Danio rerio	76.20	0.00e+00	1415.00
IUUC-Dno-029466	Dasypus novemcinctus	91.08	0.00e+00	1719.00
IUUC-Dor-030138	Dipodomys ordii	86.46	0.00e+00	1547.00
IUUC-Ete-033145	Echinops telfairi	84.09	0.00e+00	1231.00
IUUC-Eca-033445	Equus caballus	91.73	0.00e+00	1509.00
IUUC-Eeu-035247	Erinaceus europaeus	83.26	0.00e+00	1419.00
IUUC-Fca-035489	Felis catus	88.48	0.00e+00	1457.00
IUUC-Gmo-039674	Gadus morhua	75.30	0.00e+00	1376.00
IUUC-Gga-040703	Gallus gallus	93.61	0.00e+00	1762.00
IUUC-Gac-042020	Gasterosteus aculeatus	77.36	0.00e+00	1406.00
IUUC-Ggo-045332	Gorilla gorilla	90.27	0.00e+00	1645.00
IUUC-Hsa-045968	Homo sapiens	91.48	0.00e+00	1721.00
IUUC-Lch-050443	Latimeria chalumnae	84.63	0.00e+00	1425.00
IUUC-Loc-052662	Lepisosteus oculatus	78.83	0.00e+00	1432.00
IUUC-Lma-053159	Leptosphaeria maculans	44.56	8.00e-93	337.00
IUUC-Laf-053850	Loxodonta africana	90.79	0.00e+00	1692.00
IUUC-Mcc-055821	Macaca mulatta	92.12	0.00e+00	1718.00
IUUC-Meu-056712	Macropus eugenii	75.38	0.00e+00	729.00
IUUC-Mmr-060798	Microcebus murinus	87.08	0.00e+00	1592.00
IUUC-Mdo-062173	Monodelphis domestica	93.20	0.00e+00	1779.00
IUUC-Mmu-064136	Mus musculus	90.68	0.00e+00	1686.00
IUUC-Mpu-066765	Mustela putorius furo	90.24	0.00e+00	1699.00
IUUC-Mlu-067565	Myotis lucifugus	89.86	0.00e+00	1514.00
IUUC-Nfi-068427	Neosartorya fischeri	47.54	7.00e-159	554.00
IUUC-Nle-069070	Nomascus leucogenys	87.74	0.00e+00	1625.00
IUUC-Opr-071044	Ochotona princeps	90.51	0.00e+00	1153.00
IUUC-Ont-072044	Oreochromis niloticus	75.34	0.00e+00	1443.00
IUUC-Oan-073032	Ornithorhynchus anatinus	87.46	0.00e+00	1373.00
IUUC-Ocu-074160	Oryctolagus cuniculus	89.67	0.00e+00	1639.00
IUUC-Ola-087467	Oryzias latipes	77.40	0.00e+00	1434.00
IUUC-Oga-088460	Otolemur garnettii	87.50	0.00e+00	1492.00
IUUC-Oar-090198	Ovis aries	90.67	0.00e+00	1692.00
IUUC-Ptr-090939	Pan troglodytes	91.48	0.00e+00	1721.00
IUUC-Pan-092284	Papio anubis	91.38	0.00e+00	1718.00
IUUC-Psi-093645	Pelodiscus sinensis	91.89	0.00e+00	1708.00
IUUC-Pma-094364	Petromyzon marinus	79.27	0.00e+00	848.00
IUUC-Pfo-096768	Poecilia formosa	87.90	0.00e+00	947.00
IUUC-Pab-098088	Pongo abelii	91.85	0.00e+00	1720.00
IUUC-Pca-100714	Procavia capensis	78.49	0.00e+00	1112.00
IUUC-Pva-102354	Pteropus vampyrus	89.93	0.00e+00	1603.00
IUUC-Rno-105318	Rattus norvegicus	90.49	0.00e+00	1664.00
IUUC-Sha-107482	Sarcophilus harrisii	91.00	0.00e+00	1550.00
IUUC-Stu-112582	Solanum tuberosum	36.36	9.00e-55	208.00
IUUC-Sbi-113794	Sorghum bicolor	45.00	1.00e-92	336.00
IUUC-Ssc-115950	Sus scrofa	67.88	0.00e+00	1119.00
IUUC-Tgu-117130	Taeniopygia guttata	96.94	0.00e+00	1803.00
IUUC-Tru-118610	Takifugu rubripes	77.83	0.00e+00	1456.00
IUUC-Tsy-119492	Tarsius syrichta	86.28	0.00e+00	1553.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.93	0.00e+00	1350.00
IUUC-Tre-122203	Trichoderma reesei	43.33	2.00e-149	522.00
IUUC-Tbe-127441	Tupaia belangeri	81.11	0.00e+00	717.00
IUUC-Ttr-128235	Tursiops truncatus	82.83	0.00e+00	1433.00
IUUC-Xtr-132859	Xenopus tropicalis	87.47	0.00e+00	1628.00
IUUC-Xma-133797	Xiphophorus maculatus	78.23	0.00e+00	1438.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence