iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mvi-060395

Ensembl Protein ID

MVLG_05560T0

UniProt Accession

U5HEL7; U5HEL7_USTV1

Genbank Protein ID

KDE03991.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEIJ01000585

Gene Name

MVLG_05560

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MVLG_05560	MVLG_05560T0	MVLG_05560T0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-124	412.6	510	841

Active Site

Position(s)	Description	Evidence
810	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyk 98
           ++dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+s + npehl +F+f+Gr+l +a++++r+ld+ + +++yk
   Q: 510  PNDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSSI-NPEHLTYFKFIGRVLSLAVFHRRFLDAYFITALYK 605
           579*********************************************************9.89********************************* PP
   S: 99   lllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafre 195
           ++l+kk++l+d+e+vd+e+++sl++++en   di++  ld tfs++++ +get + +LkpgG ++ Vtn+Nk+eYv+lv+e+r++++++ q++af +
   Q: 606  MVLKKKITLQDMESVDAEMFRSLTWMLEN---DITDV-LDNTFSAEDDRFGETVTIDLKPGGLDVAVTNDNKKEYVQLVTEWRIQKRVEDQFKAFLS 698
           ***************************99...9***8.*********************************************************** PP
   S: 196  GfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfv 288
           Gfne+ip+el+++F+e+elelli G++eidv+d+ k+t y+g yt+ ++++qwFw++++e+ +e+++++LqF+Tg+sr+P++Gf++l+    pr+f+
   Q: 699  GFNELIPQELINVFDERELELLIGGMSEIDVDDWMKHTDYRG-YTQADEVVQWFWKAVKEWPAEKKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFT 794
           ****************************************76.****************************************************** PP
   S: 289  irkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++k+++ ++lP+s+TCfn+L+LP Y+s e+l++kL +A+e+t gF++
   Q: 795  LEKSGEVTQLPKSHTCFNRLDLPAYPSFEVLEQKLAFAVENTLGFGQ 841
           *********************************************86 PP

Organism

Microbotryum violaceum

Protein Sequence
(Fasta)

MSSGAAVPDA NRTRKIRVTV VAADSLAKRD VFRLPDPFAV VTVDGEQTNT TSAIKKTLNP 60
YWNESFDVLV KDGSVLTVQI FDQKKFKKKD QGFLGVINLP VSQAIDLDLG GEDTFTRELK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCTCCTCG CGCTGACCGA GGCGTGCAGC TCGTGTTCGG TCCGTTCATT CCACCCCCGC 60
CCTCGAGTCA GCTCGCACCA TGTCGAGTGG TGCCGCAGTC CCCGATGCCA ACAGGGTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	47.19	4.00e-155	541.00
IUUC-Apl-003893	Anas platyrhynchos	48.18	5.00e-151	526.00
IUUC-Aca-005338	Anolis carolinensis	46.43	6.00e-155	539.00
IUUC-Ago-007742	Ashbya gossypii	68.46	0.00e+00	861.00
IUUC-Acl-008273	Aspergillus clavatus	63.60	0.00e+00	981.00
IUUC-Afl-008713	Aspergillus flavus	63.92	0.00e+00	987.00
IUUC-Afu-009103	Aspergillus fumigatus	60.88	0.00e+00	959.00
IUUC-Ani-009259	Aspergillus nidulans	63.99	0.00e+00	989.00
IUUC-Ang-009738	Aspergillus niger	63.61	0.00e+00	998.00
IUUC-Aor-010053	Aspergillus oryzae	73.91	5.00e-139	485.00
IUUC-Ate-010529	Aspergillus terreus	64.03	0.00e+00	998.00
IUUC-Ame-010810	Astyanax mexicanus	54.45	3.00e-147	514.00
IUUC-Bgr-012148	Blumeria graminis	62.78	0.00e+00	947.00
IUUC-Bta-012679	Bos taurus	46.79	9.00e-151	525.00
IUUC-Bci-013785	Botrytis cinerea	61.96	0.00e+00	972.00
IUUC-Cel-018299	Caenorhabditis elegans	43.21	2.00e-139	487.00
IUUC-Cja-018732	Callithrix jacchus	46.79	3.00e-151	527.00
IUUC-Cfa-020258	Canis familiaris	53.58	3.00e-152	531.00
IUUC-Cpo-021671	Cavia porcellus	46.46	1.00e-150	525.00
IUUC-Csa-023334	Chlorocebus sabaeus	53.58	3.00e-150	523.00
IUUC-Cho-024695	Choloepus hoffmanni	51.45	5.00e-150	523.00
IUUC-Cin-025126	Ciona intestinalis	48.71	2.00e-134	471.00
IUUC-Csv-026339	Ciona savignyi	44.02	5.00e-145	506.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	60.60	0.00e+00	958.00
IUUC-Cne-026849	Cryptococcus neoformans	64.27	0.00e+00	1076.00
IUUC-Dre-027770	Danio rerio	54.71	1.00e-149	521.00
IUUC-Dno-029466	Dasypus novemcinctus	46.62	9.00e-151	526.00
IUUC-Dor-030138	Dipodomys ordii	45.80	2.00e-146	511.00
IUUC-Dse-031241	Dothistroma septosporum	65.22	0.00e+00	1038.00
IUUC-Dme-032166	Drosophila melanogaster	50.71	3.00e-143	501.00
IUUC-Ete-032779	Echinops telfairi	43.98	4.00e-138	483.00
IUUC-Eca-033445	Equus caballus	46.62	1.00e-150	525.00
IUUC-Eeu-035247	Erinaceus europaeus	46.29	5.00e-148	516.00
IUUC-Fca-036384	Felis catus	47.36	2.00e-153	535.00
IUUC-Fal-037126	Ficedula albicollis	46.63	2.00e-155	541.00
IUUC-Fox-037774	Fusarium oxysporum	60.94	0.00e+00	955.00
IUUC-Fso-038393	Fusarium solani	60.31	0.00e+00	930.00
IUUC-Gmo-039674	Gadus morhua	54.66	2.00e-145	508.00
IUUC-Ggr-040107	Gaeumannomyces graminis	61.47	0.00e+00	964.00
IUUC-Gga-041276	Gallus gallus	48.84	4.00e-150	523.00
IUUC-Gac-042020	Gasterosteus aculeatus	47.78	2.00e-148	518.00
IUUC-Ggo-045332	Gorilla gorilla	46.46	2.00e-150	525.00
IUUC-Hsa-046479	Homo sapiens	52.22	5.00e-152	530.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	45.41	3.00e-152	530.00
IUUC-Kpa-049273	Komagataella pastoris	61.93	0.00e+00	986.00
IUUC-Lch-050443	Latimeria chalumnae	46.88	1.00e-149	522.00
IUUC-Loc-052662	Lepisosteus oculatus	48.43	3.00e-145	507.00
IUUC-Lma-052980	Leptosphaeria maculans	58.38	5.00e-157	545.00
IUUC-Laf-053850	Loxodonta africana	46.29	2.00e-150	525.00
IUUC-Mcc-055821	Macaca mulatta	46.46	9.00e-151	526.00
IUUC-Meu-056436	Macropus eugenii	45.32	3.00e-118	417.00
IUUC-Mor-057097	Magnaporthe oryzae	61.65	0.00e+00	984.00
IUUC-Mpo-057442	Magnaporthe poae	76.37	0.00e+00	813.00
IUUC-Mla-058996	Melampsora laricipopulina	68.43	0.00e+00	1123.00
IUUC-Mga-059362	Meleagris gallopavo	47.37	1.00e-148	518.00
IUUC-Mmr-061061	Microcebus murinus	48.01	1.00e-156	546.00
IUUC-Mdo-062505	Monodelphis domestica	45.96	2.00e-153	535.00
IUUC-Mmu-064136	Mus musculus	46.62	1.00e-150	525.00
IUUC-Mpu-066765	Mustela putorius furo	46.62	1.00e-150	525.00
IUUC-Mlu-067565	Myotis lucifugus	46.79	1.00e-150	525.00
IUUC-Nfi-068427	Neosartorya fischeri	63.53	0.00e+00	985.00
IUUC-Ncr-068918	Neurospora crassa	61.96	0.00e+00	955.00
IUUC-Nle-069225	Nomascus leucogenys	47.41	2.00e-153	535.00
IUUC-Opr-071044	Ochotona princeps	46.29	9.00e-148	516.00
IUUC-Ont-072044	Oreochromis niloticus	54.94	2.00e-154	538.00
IUUC-Oan-073019	Ornithorhynchus anatinus	42.50	8.00e-146	509.00
IUUC-Ocu-074409	Oryctolagus cuniculus	54.02	4.00e-153	534.00
IUUC-Ola-087467	Oryzias latipes	47.37	5.00e-150	523.00
IUUC-Oga-088460	Otolemur garnettii	46.79	2.00e-150	524.00
IUUC-Oar-090198	Ovis aries	48.01	5.00e-150	523.00
IUUC-Ptr-091629	Pan troglodytes	52.22	6.00e-152	530.00
IUUC-Pan-092284	Papio anubis	46.79	1.00e-150	525.00
IUUC-Psi-093645	Pelodiscus sinensis	48.02	2.00e-151	528.00
IUUC-Pma-094364	Petromyzon marinus	52.58	8.00e-143	498.00
IUUC-Pno-095118	Phaeosphaeria nodorum	60.66	0.00e+00	996.00
IUUC-Pfo-096768	Poecilia formosa	53.39	2.00e-147	514.00
IUUC-Pab-098088	Pongo abelii	46.46	1.00e-150	525.00
IUUC-Pca-100596	Procavia capensis	50.10	5.00e-142	496.00
IUUC-Pva-102354	Pteropus vampyrus	46.13	8.00e-150	522.00
IUUC-Pgr-103620	Puccinia graminis	75.28	0.00e+00	951.00
IUUC-Ptt-103806	Puccinia triticina	86.41	0.00e+00	778.00
IUUC-Pte-104016	Pyrenophora teres	62.95	0.00e+00	1005.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	62.95	0.00e+00	1005.00
IUUC-Rno-105318	Rattus norvegicus	46.29	1.00e-150	525.00
IUUC-Sce-106289	Saccharomyces cerevisiae	62.01	0.00e+00	956.00
IUUC-Sha-107482	Sarcophilus harrisii	52.15	8.00e-145	506.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	61.12	0.00e+00	1008.00
IUUC-Spo-108171	Schizosaccharomyces pombe	61.86	0.00e+00	996.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	61.31	0.00e+00	962.00
IUUC-Stu-112894	Solanum tuberosum	32.51	1.00e-52	199.00
IUUC-Sar-113761	Sorex araneus	45.17	9.00e-149	519.00
IUUC-Sre-114929	Sporisorium reilianum	75.08	0.00e+00	931.00
IUUC-Ssc-115368	Sus scrofa	45.20	2.00e-148	518.00
IUUC-Tgu-117130	Taeniopygia guttata	48.02	3.00e-151	527.00
IUUC-Tru-118610	Takifugu rubripes	54.53	6.00e-153	533.00
IUUC-Tsy-119492	Tarsius syrichta	46.62	3.00e-149	521.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.31	1.00e-145	508.00
IUUC-Tre-122203	Trichoderma reesei	61.98	0.00e+00	948.00
IUUC-Tvi-122595	Trichoderma virens	61.65	0.00e+00	957.00
IUUC-Tme-126897	Tuber melanosporum	79.96	0.00e+00	827.00
IUUC-Tbe-127793	Tupaia belangeri	48.45	8.00e-137	479.00
IUUC-Ttr-128235	Tursiops truncatus	52.47	9.00e-146	509.00
IUUC-Uma-129332	Ustilago maydis	74.92	0.00e+00	897.00
IUUC-Vda-129753	Verticillium dahliae	61.35	0.00e+00	927.00
IUUC-Vpa-130503	Vicugna pacos	52.76	1.00e-141	496.00
IUUC-Xtr-132859	Xenopus tropicalis	48.11	7.00e-152	529.00
IUUC-Xma-133797	Xiphophorus maculatus	47.78	7.00e-151	526.00
IUUC-Yli-134668	Yarrowia lipolytica	67.04	0.00e+00	860.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence