iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052805

Ensembl Protein ID

ENSLOCP00000014766.1

UniProt Accession

W5N2A7; W5N2A7_LEPOC

Genbank Protein ID

ENSLOCP00000014766

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01017243

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000011999.1	ENSLOCT00000014795.1	ENSLOCP00000014766.1
ENSLOCG00000011999.1	ENSLOCT00000014801.1	ENSLOCP00000014772.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-11	43.1	3374	3406
E3 activity/HECT	2.10e-82	277.4	4455	4790

Active Site

Position(s)	Description	Evidence
4759	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++vt++++  + +ll++++ Dgt+++W+++
   Q: 3374 GHHNRVTSCSWsGEtGLLATSAQDGTVRLWNIT 3406
           79999******8446****************76 PP

E3 activity/HECT

   S: 5    lkkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdg 85
           l +r++ v++vgE + d+gGv+ ++++++++el++  + l+ +++n+++ +  n d++l np     eh+  F+flG+l+++a++++
   Q: 4455 LPSRAWkVKLVGEGADDAGGVFDDTITEMCQELESGVVDLLIQTPNSSADVGSNTDRFLLNPsaiseEHMIQFRFLGILMAVAVRTK 4541
           5566666******************************************************************************** PP
   S: 86   rlldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNk 170
           ++ldl+l++ ++k+l+  +l+ +dleevd  + +sl+ i+++++s i+e ++ +++  ++   ++++ +    +pgG n+p t +N+
   Q: 4542 KPLDLHLAPWVWKQLCFIPLNAQDLEEVDLLTSRSLQGILHLENSGITEDNFPVMIPLDSFTAQSADGKLvpVVPGGYNVPLTFANR 4628
           ********************************************************999988877777755589************* PP
   S: 171  eeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefs 257
           +eYv++ +eyrl+e ++ qv+a+reG++++ip  llsl+t+++le+++cG++e++ve+lkk  +y++ +t++++ i w+w++leef+
   Q: 4629 KEYVERAIEYRLHE-MDLQVAAVREGMSSIIPVPLLSLLTARQLEQMVCGMPEVSVETLKKVVRYRD-VTDTHQLIGWLWQTLEEFT 4713
           **************.**************************************************88.******************* PP
   S: 258  seerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +eer  fL+Fv+g+srlP  + a++  ++f+i k d+  + lP+++TCf++L+LP+Y+s+ ++ e+L+y i ++ ++++
   Q: 4714 NEERVLFLRFVSGRSRLP-SNTADIT-QKFQIIKvDRPVNGLPTAQTCFFQLRLPPYTSQAVMAERLRYSIYNCPSIDM 4790
           ******************.5788888.456666648888**********************************988776 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MVPCQTHVML KWQEHLNGSW AAEDSVQVTI RQGAAALYSK LLSNKEVVGL AQPVQDLLGP 60
RLPDFQYEAS ATEEREEYLA ALLHSQRCLV RRTLASTPYA LSLHHRLVVL QRIYYALHSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGCAGTGA CGTTTAGTTG CAGTTCCTAC GACACGCGTG TGCACGCACA ATGCGTGGAG 60
GGCTGCGCTG TTTTTCATGG CAACAAACGG TAGAGTTGTT TAGAGATAGG ACCACGGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006545	Arabidopsis lyrata	37.94	8.00e-51	195.00
IUUC-Ame-011268	Astyanax mexicanus	71.99	0.00e+00	3028.00
IUUC-Bol-015203	Brassica oleracea	37.06	1.00e-52	201.00
IUUC-Gac-042444	Gasterosteus aculeatus	63.98	0.00e+00	5730.00
IUUC-Hvu-047529	Hordeum vulgare	34.97	7.00e-51	196.00
IUUC-Ola-086308	Oryzias latipes	62.01	0.00e+00	5329.00
IUUC-Pfo-096464	Poecilia formosa	63.70	0.00e+00	5539.00
IUUC-Pop-099121	Populus trichocarpa	35.79	3.00e-54	207.00
IUUC-Tru-118723	Takifugu rubripes	63.76	0.00e+00	5684.00
IUUC-Tur-126300	Triticum urartu	34.97	3.00e-51	197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence