iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088379

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03143600

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000001114.2	ENSOGAT00000001116.2	ENSOGAP00000000992.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-73	247.5	194	820

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprel 73
           +G++NlgNtC++N+++Q L+++  l+el++e  +++ kl+                   ++ g+l+++l  +++++ ++ k+  sp+ l
   Q: 194  KGITNLGNTCFFNAIMQNLAHTYILKELMNEikENNTKLK---IfppsdsqldplvveLSSPGPLTSALFLFLHSM-ETGKGPLSPTVL 278
           59*****************************443333343...23457777777777777777*************.999********* PP
   S: 74   lkalkkeaeefsgyeqqDaqEflaflldqleeelkk....eknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlks 152
           +++l++ a+  ++++ q ++ +  f l+ l +++k+    + + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s
   Q: 279  FNQLCQNAPVRNNFQGQSCSQLHLFNLHYLLTQIKRsedkRIQVSILKAFNNPTTKTADDetrkkvKAYGKEGMKMNFIDRIFIGELTS 367
           *********9999999999998665555555555444444555555555555544444442222225566666666************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke........................................................ 185
           +++c+ec+n+s+ ++pf+d+slp+ +++ +k++                                                        
   Q: 368  TVMCEECANISTVKDPFIDISLPIIEERASKPLplgrmrsrsfqepdhdqcgatvtiensdqpkttkkhsskdknqlirnrkhrrksss 456
           ****************************98888******************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 457  veektiviyrknenlemnedsliitsikntesppnespldgsekeaslsessidadseasesesasrqtrlfrsscgarvhtgghlchp 545
           ***************************************************************************************** PP
   S: 186  ................................................................................slqdcLesf 194
                                                                                           s+q+cL +f
   Q: 546  svgelphinetdsaddmvaeavsqlhlsstvtgdrdfdtenqplsilnnlcseekhlrfhspqdafqtlsqsyvttskecSVQSCLYQF 634
           ***************************************************************************************** PP
   S: 195  tkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           t+ e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pf
   Q: 635  TSMELLIGNNKLLCENCTEKKQkyqketssaerkaegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPF 721
           ******************99999999999999999999999*********************..9999********************* PP
   S: 265  ctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevle 324
           c+ +++k+++   k+ Y L+++v H+Gs+++GHY+ayvk                           + g+W++++D +V++v+e++ l 
   Q: 722  CSATCKKNANvgeKVLYGLYGIVEHTGSMRGGHYTAYVKVrtpsrkllehitgkknvfglkepgteSAGHWVHVSDASVQVVPESRALG 810
           **98887776777***************************999999999999999999998888766777******************* PP
   S: 325  etgstaYvlfYkr 337
              ++aY+lfY+r
   Q: 811  ---AQAYLLFYER 820
           ...********98 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MRVKDPTKPL PEKAKRSKKP TIPHDEDSSD DITAYSLGLT CQHVSHAVGV NHVKRAVAEN 60
VWSVCSECLK ERRFYDGQPL LPSDIWLCLK CGFQGCGESS ESQHSLKHSR SSRTEPHCIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AAGATCCAAC CAAACCTTTA CCTGAGAAAG CCAAAAGAAG CAAAAAGCCT 60
ACTATACCTC ATGATGAAGA CTCTTCGGAT GACATTACAG GTAAATTATG TCTCCGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	68.71	0.00e+00	1016.00
IUUC-Apl-003512	Anas platyrhynchos	62.94	0.00e+00	1007.00
IUUC-Aca-004284	Anolis carolinensis	59.18	0.00e+00	914.00
IUUC-Ame-010735	Astyanax mexicanus	58.87	2.00e-84	306.00
IUUC-Bta-012880	Bos taurus	75.30	0.00e+00	1152.00
IUUC-Cja-019144	Callithrix jacchus	78.09	0.00e+00	1268.00
IUUC-Cfa-020971	Canis familiaris	73.83	0.00e+00	661.00
IUUC-Cpo-022497	Cavia porcellus	63.67	0.00e+00	986.00
IUUC-Csa-023910	Chlorocebus sabaeus	77.37	0.00e+00	1165.00
IUUC-Cho-024358	Choloepus hoffmanni	76.35	6.00e-65	241.00
IUUC-Dre-028106	Danio rerio	51.13	0.00e+00	753.00
IUUC-Dno-029456	Dasypus novemcinctus	73.58	0.00e+00	680.00
IUUC-Dor-030438	Dipodomys ordii	60.17	0.00e+00	858.00
IUUC-Dme-031870	Drosophila melanogaster	47.31	2.00e-37	151.00
IUUC-Ete-032736	Echinops telfairi	61.64	0.00e+00	887.00
IUUC-Eca-034211	Equus caballus	76.90	0.00e+00	1237.00
IUUC-Eeu-034797	Erinaceus europaeus	65.84	1.00e-67	250.00
IUUC-Fca-035947	Felis catus	72.85	0.00e+00	1048.00
IUUC-Fal-037199	Ficedula albicollis	64.41	0.00e+00	862.00
IUUC-Gmo-039228	Gadus morhua	58.50	2.00e-129	456.00
IUUC-Gga-040823	Gallus gallus	65.56	2.00e-169	588.00
IUUC-Gac-042406	Gasterosteus aculeatus	50.60	0.00e+00	712.00
IUUC-Ggo-045402	Gorilla gorilla	77.39	0.00e+00	1226.00
IUUC-Hsa-046430	Homo sapiens	77.24	0.00e+00	1228.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	78.94	0.00e+00	724.00
IUUC-Lch-049547	Latimeria chalumnae	56.34	0.00e+00	839.00
IUUC-Loc-052842	Lepisosteus oculatus	55.12	0.00e+00	832.00
IUUC-Laf-053988	Loxodonta africana	76.42	0.00e+00	1219.00
IUUC-Mcc-055491	Macaca mulatta	74.64	0.00e+00	1191.00
IUUC-Meu-056256	Macropus eugenii	61.54	4.00e-166	578.00
IUUC-Mla-059026	Melampsora laricipopulina	30.17	5.00e-17	82.80
IUUC-Mga-059833	Meleagris gallopavo	65.04	6.00e-170	590.00
IUUC-Mmr-060952	Microcebus murinus	81.84	0.00e+00	1283.00
IUUC-Mdo-062642	Monodelphis domestica	66.79	0.00e+00	1013.00
IUUC-Mmu-063945	Mus musculus	72.74	0.00e+00	1137.00
IUUC-Mpu-065944	Mustela putorius furo	70.94	0.00e+00	1081.00
IUUC-Mlu-067049	Myotis lucifugus	75.72	0.00e+00	1169.00
IUUC-Nle-069828	Nomascus leucogenys	77.15	0.00e+00	1228.00
IUUC-Opr-070672	Ochotona princeps	62.86	2.00e-122	433.00
IUUC-Ont-072121	Oreochromis niloticus	55.93	1.00e-121	430.00
IUUC-Oan-073656	Ornithorhynchus anatinus	61.36	0.00e+00	947.00
IUUC-Ocu-074323	Oryctolagus cuniculus	75.06	0.00e+00	1152.00
IUUC-Ola-087238	Oryzias latipes	50.71	0.00e+00	744.00
IUUC-Oar-089718	Ovis aries	75.48	0.00e+00	1150.00
IUUC-Ptr-091358	Pan troglodytes	77.48	0.00e+00	1232.00
IUUC-Pan-092023	Papio anubis	77.60	0.00e+00	1244.00
IUUC-Psi-093256	Pelodiscus sinensis	63.80	0.00e+00	916.00
IUUC-Pfo-097285	Poecilia formosa	49.58	0.00e+00	669.00
IUUC-Pab-098539	Pongo abelii	77.60	0.00e+00	1236.00
IUUC-Pca-100610	Procavia capensis	62.04	0.00e+00	811.00
IUUC-Pva-102985	Pteropus vampyrus	79.58	1.00e-176	613.00
IUUC-Rno-105538	Rattus norvegicus	71.91	0.00e+00	1137.00
IUUC-Sha-107022	Sarcophilus harrisii	65.79	2.00e-163	569.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.93	5.00e-20	93.20
IUUC-Sar-113637	Sorex araneus	65.45	0.00e+00	959.00
IUUC-Ssc-115870	Sus scrofa	75.79	0.00e+00	1206.00
IUUC-Tgu-116907	Taeniopygia guttata	65.50	0.00e+00	995.00
IUUC-Tru-117835	Takifugu rubripes	43.03	9.00e-96	344.00
IUUC-Tsy-118869	Tarsius syrichta	77.53	0.00e+00	1094.00
IUUC-Tni-119716	Tetraodon nigroviridis	66.05	2.00e-85	309.00
IUUC-Tbe-128041	Tupaia belangeri	65.71	0.00e+00	835.00
IUUC-Ttr-128901	Tursiops truncatus	74.82	0.00e+00	1179.00
IUUC-Vpa-130331	Vicugna pacos	76.57	0.00e+00	1122.00
IUUC-Xtr-131794	Xenopus tropicalis	49.52	0.00e+00	701.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence