iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	miRNAMap
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-67	224.2	270	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +ke++++ ++y+++n+deLt+++G+++++i+ke+ ++gW+kg  el+gk+G+fP+nF ++++
   Q: 270  AKEYCKTVFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG--ELNGKEGVFPDNFAVQIS 329
           689***************************************..9*************9986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

Protein Sequence
(Fasta)

MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE 60
TEPKDDNLPI KRERPGNVAS LVQRISTYGL PAGGIQPHPQ TKAMKKKTKK RQCKVLFEYS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCGGGCT TGAGGAGCGG CCGAGCGCGC CGCGGGCGGA TGGAGGCGTC TCCCCGCCGC 60
GCCTGAGACG GTGCACAGAA GGGGCCGCGG GGCCACGCTT TCCTCGCCAG AGCCGCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
KW-0832--Ubl conjugation

Interpro

IPR028445--CD2AP
IPR001452--SH3_domain

PROSITE

PS50002--SH3

Pfam

PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0031252--C:cell leading edge
GO:0005911--C:cell-cell junction
GO:0030139--C:endocytic vesicle
GO:0070062--C:extracellular exosome
GO:0031941--C:filamentous actin
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0005172--F:vascular endothelial growth factor receptor binding
GO:0051301--P:cell division
GO:0016477--P:cell migration
GO:0007067--P:mitotic nuclear division
GO:0032911--P:negative regulation of transforming growth factor beta1 production
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000249--P:regulation of actin cytoskeleton reorganization
GO:0048259--P:regulation of receptor-mediated endocytosis
GO:0016337--P:single organismal cell-cell adhesion
GO:0016050--P:vesicle organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001574	Ailuropoda melanoleuca	83.31	0.00e+00	891.00
IUUC-Apl-003573	Anas platyrhynchos	61.14	4.00e-147	514.00
IUUC-Aca-005118	Anolis carolinensis	61.67	1.00e-156	546.00
IUUC-Ame-010657	Astyanax mexicanus	41.19	4.00e-96	345.00
IUUC-Bta-012577	Bos taurus	80.56	0.00e+00	789.00
IUUC-Cja-020010	Callithrix jacchus	84.19	0.00e+00	867.00
IUUC-Cfa-020040	Canis familiaris	85.27	0.00e+00	909.00
IUUC-Cpo-021906	Cavia porcellus	77.69	0.00e+00	783.00
IUUC-Csa-024008	Chlorocebus sabaeus	85.13	0.00e+00	829.00
IUUC-Cho-024359	Choloepus hoffmanni	53.21	1.00e-72	267.00
IUUC-Cin-025154	Ciona intestinalis	59.26	1.00e-13	67.00
IUUC-Csv-026228	Ciona savignyi	40.37	8.00e-25	105.00
IUUC-Dre-027661	Danio rerio	54.47	1.00e-91	330.00
IUUC-Dno-029568	Dasypus novemcinctus	81.12	0.00e+00	803.00
IUUC-Dor-030286	Dipodomys ordii	72.80	0.00e+00	686.00
IUUC-Ete-032576	Echinops telfairi	80.08	2.00e-105	376.00
IUUC-Eca-033438	Equus caballus	84.51	0.00e+00	891.00
IUUC-Eeu-034588	Erinaceus europaeus	68.51	1.00e-136	479.00
IUUC-Fca-036597	Felis catus	84.87	0.00e+00	899.00
IUUC-Fal-037305	Ficedula albicollis	63.08	1.00e-156	546.00
IUUC-Gmo-039516	Gadus morhua	45.16	2.00e-63	236.00
IUUC-Gga-040979	Gallus gallus	64.25	7.00e-174	603.00
IUUC-Gac-041945	Gasterosteus aculeatus	40.30	8.00e-85	308.00
IUUC-Ggo-044488	Gorilla gorilla	85.13	0.00e+00	861.00
IUUC-Hsa-045909	Homo sapiens	84.98	0.00e+00	859.00
IUUC-Itr-049058	Ictidomys tridecemlineatus	84.45	1.00e-118	419.00
IUUC-Lch-049481	Latimeria chalumnae	55.38	4.00e-148	518.00
IUUC-Loc-052715	Lepisosteus oculatus	50.45	4.00e-128	452.00
IUUC-Laf-053444	Loxodonta africana	80.81	0.00e+00	846.00
IUUC-Mcc-054844	Macaca mulatta	85.29	0.00e+00	831.00
IUUC-Meu-056491	Macropus eugenii	64.54	3.00e-173	601.00
IUUC-Mla-059069	Melampsora laricipopulina	43.10	1.00e-07	50.80
IUUC-Mga-060154	Meleagris gallopavo	63.78	1.00e-171	596.00
IUUC-Mmr-061099	Microcebus murinus	83.57	0.00e+00	856.00
IUUC-Mdo-062769	Monodelphis domestica	70.23	0.00e+00	740.00
IUUC-Mmu-063136	Mus musculus	93.25	0.00e+00	892.00
IUUC-Mpu-066509	Mustela putorius furo	82.74	0.00e+00	810.00
IUUC-Mlu-067174	Myotis lucifugus	82.06	0.00e+00	840.00
IUUC-Nle-070147	Nomascus leucogenys	85.29	0.00e+00	870.00
IUUC-Opr-070752	Ochotona princeps	79.09	5.00e-154	538.00
IUUC-Ont-071810	Oreochromis niloticus	54.34	7.00e-99	355.00
IUUC-Oan-072731	Ornithorhynchus anatinus	70.98	5.00e-160	557.00
IUUC-Ocu-074331	Oryctolagus cuniculus	84.69	0.00e+00	847.00
IUUC-Ola-086404	Oryzias latipes	53.37	2.00e-81	296.00
IUUC-Oga-088200	Otolemur garnettii	84.82	0.00e+00	887.00
IUUC-Oar-090423	Ovis aries	79.00	0.00e+00	761.00
IUUC-Ptr-091230	Pan troglodytes	85.29	0.00e+00	865.00
IUUC-Pan-091823	Papio anubis	84.98	0.00e+00	830.00
IUUC-Psi-093127	Pelodiscus sinensis	59.93	9.00e-147	513.00
IUUC-Pfo-096539	Poecilia formosa	48.67	1.00e-87	317.00
IUUC-Pab-097666	Pongo abelii	85.92	0.00e+00	862.00
IUUC-Pca-100812	Procavia capensis	78.73	3.00e-125	442.00
IUUC-Pva-102260	Pteropus vampyrus	77.23	0.00e+00	696.00
IUUC-Sha-106975	Sarcophilus harrisii	71.86	0.00e+00	718.00
IUUC-Sar-113386	Sorex araneus	83.33	5.00e-104	371.00
IUUC-Ssc-115569	Sus scrofa	87.85	2.00e-110	391.00
IUUC-Tgu-117104	Taeniopygia guttata	63.27	3.00e-168	585.00
IUUC-Tru-117649	Takifugu rubripes	49.74	3.00e-95	343.00
IUUC-Tsy-119258	Tarsius syrichta	76.80	0.00e+00	768.00
IUUC-Tni-120755	Tetraodon nigroviridis	44.49	2.00e-118	419.00
IUUC-Tbe-127842	Tupaia belangeri	66.29	1.00e-111	397.00
IUUC-Ttr-129205	Tursiops truncatus	83.39	0.00e+00	734.00
IUUC-Vpa-130434	Vicugna pacos	79.79	0.00e+00	680.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence