iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064138

UUCD1 version

UUC-MuM-00220

Ensembl Protein ID

ENSMUSP00000046843.6

UniProt Accession

Q80Z37; Q3U5B5; Q3UPZ1; Q3USN3; Q3UZ55; Q8BXP2; Q8CFF5; Q8CGC8; Q920L3; TOPRS_MOUSE

Genbank Protein ID

BAB69457.1; BAC65157.1; AAH37141.1; AAH40797.1; BAC31981.2; BAE22003.1; BAE24298.1; BAE25253.1; BAE32164.1

Protein Name

E3 ubiquitin-protein ligase Topors; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Tumor suppressor p53-binding protein 3

Genbank Nucleotide ID

AB072395; AB104865; BC037141; BC040797; AK044564; AK134075; AK140250; AK143025; AK153743

Gene Name

Topors

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000036822.6	ENSMUST00000042575.6	ENSMUSP00000046843.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-09	37.2	104	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f++  ++ +C H f++ C+q w      s++++ CPlC+
   Q: 104  CPICLDRFDNVSYLDRCLHKFCFRCVQEW------SKNKAECPLCK 143
           **********999999*************......**********7 PP

Organism

Mus musculus

Functional Description
(View)

Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.

Protein Sequence
(Fasta)

MGSQPPPPGS PLSREEGEAP PLVPAEEGRR RSRRVRLRGS CRHRPSLLSR RELASNGPAV 60
PATASSEIMA SAAKEFKMDN FSPKAGTSKL QQTVPADASP DSKCPICLDR FDNVSYLDRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGAGGGCA GGGCGTGAAC GCTCAATTTA GGAATGGGTT CTGGAGTTCC AAGCTGCGAG 60
CCAACAGTCT ACCTTCGGCT CGCGGGCCCT GCCATGGTGC GCTCTGGAGC TCCGCTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0000930--C:gamma-tubulin complex
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032391--C:photoreceptor connecting cilium
GO:0016605--C:PML body
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0003823--F:antigen binding
GO:0003677--F:DNA binding
GO:0044547--F:DNA topoisomerase binding
GO:0019789--F:SUMO transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0051457--P:maintenance of protein location in nucleus
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0034504--P:protein localization to nucleus
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016925--P:protein sumoylation
GO:0042127--P:regulation of cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:106021

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000940	Aegilops tauschii	36.76	3.00e-09	55.80
IUUC-Aml-002240	Ailuropoda melanoleuca	84.98	0.00e+00	846.00
IUUC-Atr-002964	Amborella trichopoda	35.42	2.00e-13	68.90
IUUC-Apl-003666	Anas platyrhynchos	56.84	1.00e-139	490.00
IUUC-Aca-005305	Anolis carolinensis	62.71	1.00e-145	510.00
IUUC-Aly-005926	Arabidopsis lyrata	36.17	3.00e-11	62.00
IUUC-Ath-007299	Arabidopsis thaliana	35.11	1.00e-11	63.90
IUUC-Ame-011109	Astyanax mexicanus	53.44	8.00e-110	391.00
IUUC-Bta-012637	Bos taurus	88.04	0.00e+00	875.00
IUUC-Bdi-014270	Brachypodium distachyon	40.00	2.00e-11	62.80
IUUC-Bol-015307	Brassica oleracea	32.98	5.00e-10	58.20
IUUC-Bra-017073	Brassica rapa	44.90	2.00e-08	52.00
IUUC-Cja-019105	Callithrix jacchus	89.01	0.00e+00	910.00
IUUC-Cfa-021203	Canis familiaris	85.90	0.00e+00	838.00
IUUC-Cpo-022335	Cavia porcellus	82.59	0.00e+00	805.00
IUUC-Csa-023870	Chlorocebus sabaeus	88.12	0.00e+00	896.00
IUUC-Cho-024870	Choloepus hoffmanni	86.29	0.00e+00	838.00
IUUC-Cne-026788	Cryptococcus neoformans	33.85	4.00e-07	50.10
IUUC-Dre-027535	Danio rerio	50.20	3.00e-123	436.00
IUUC-Dno-028963	Dasypus novemcinctus	86.18	0.00e+00	818.00
IUUC-Dor-030239	Dipodomys ordii	85.28	0.00e+00	742.00
IUUC-Dme-031941	Drosophila melanogaster	48.31	2.00e-20	94.70
IUUC-Ete-032300	Echinops telfairi	77.40	0.00e+00	1025.00
IUUC-Eca-033690	Equus caballus	88.19	0.00e+00	846.00
IUUC-Eeu-035257	Erinaceus europaeus	84.83	0.00e+00	808.00
IUUC-Fca-036383	Felis catus	84.97	0.00e+00	832.00
IUUC-Fal-037209	Ficedula albicollis	63.11	4.00e-157	549.00
IUUC-Gmo-039416	Gadus morhua	54.42	6.00e-118	417.00
IUUC-Gga-041267	Gallus gallus	70.49	2.00e-166	580.00
IUUC-Gac-042227	Gasterosteus aculeatus	48.83	2.00e-113	402.00
IUUC-Gma-042777	Glycine max	26.54	4.00e-09	55.50
IUUC-Ggo-044445	Gorilla gorilla	89.58	0.00e+00	915.00
IUUC-Hsa-045844	Homo sapiens	89.76	0.00e+00	917.00
IUUC-Hvu-047531	Hordeum vulgare	46.00	1.00e-10	57.40
IUUC-Itr-048818	Ictidomys tridecemlineatus	87.39	0.00e+00	874.00
IUUC-Lch-050031	Latimeria chalumnae	63.96	2.00e-159	556.00
IUUC-Lpe-051274	Leersia perrieri	37.74	1.00e-08	53.90
IUUC-Loc-052944	Lepisosteus oculatus	58.59	1.00e-139	490.00
IUUC-Laf-053820	Loxodonta africana	88.82	0.00e+00	807.00
IUUC-Mcc-054800	Macaca mulatta	87.93	0.00e+00	891.00
IUUC-Meu-056806	Macropus eugenii	73.84	2.00e-178	618.00
IUUC-Mtr-058378	Medicago truncatula	34.58	2.00e-12	66.20
IUUC-Mla-059017	Melampsora laricipopulina	36.07	4.00e-09	55.50
IUUC-Mvi-060417	Microbotryum violaceum	25.26	1.00e-16	82.00
IUUC-Mmr-061481	Microcebus murinus	88.48	0.00e+00	862.00
IUUC-Mdo-062219	Monodelphis domestica	75.56	4.00e-99	355.00
IUUC-Mac-064635	Musa acuminata	38.57	4.00e-11	60.50
IUUC-Mlu-067088	Myotis lucifugus	86.23	0.00e+00	860.00
IUUC-Nle-069862	Nomascus leucogenys	88.60	0.00e+00	919.00
IUUC-Opr-071076	Ochotona princeps	86.95	0.00e+00	744.00
IUUC-Ont-072225	Oreochromis niloticus	50.11	3.00e-109	389.00
IUUC-Oan-073069	Ornithorhynchus anatinus	66.29	1.00e-155	543.00
IUUC-Ocu-074826	Oryctolagus cuniculus	89.19	0.00e+00	881.00
IUUC-Oba-075429	Oryza barthii	37.68	2.00e-10	60.10
IUUC-Obr-076084	Oryza brachyantha	36.23	5.00e-10	58.20
IUUC-Ogl-077444	Oryza glaberrima	37.68	2.00e-10	59.70
IUUC-Ogu-078603	Oryza glumaepatula	37.68	2.00e-10	60.10
IUUC-Oin-079777	Oryza indica	37.68	2.00e-10	59.70
IUUC-Oni-082396	Oryza nivara	37.68	2.00e-10	60.10
IUUC-Opu-083698	Oryza punctata	36.62	9.00e-10	57.80
IUUC-Oru-084305	Oryza rufipogon	37.68	2.00e-10	59.70
IUUC-Ola-087377	Oryzias latipes	55.53	2.00e-107	382.00
IUUC-Oga-088059	Otolemur garnettii	85.16	0.00e+00	867.00
IUUC-Oar-089592	Ovis aries	89.20	0.00e+00	836.00
IUUC-Ptr-091233	Pan troglodytes	89.95	0.00e+00	918.00
IUUC-Pan-092743	Papio anubis	87.93	0.00e+00	893.00
IUUC-Psi-093669	Pelodiscus sinensis	59.20	0.00e+00	813.00
IUUC-Ppa-095668	Physcomitrella patens	26.35	2.00e-21	97.10
IUUC-Pfo-096706	Poecilia formosa	54.86	5.00e-105	375.00
IUUC-Pop-099119	Populus trichocarpa	23.76	1.00e-12	67.00
IUUC-Pca-100967	Procavia capensis	87.27	0.00e+00	748.00
IUUC-Ppe-101922	Prunus persica	26.91	1.00e-12	66.60
IUUC-Pva-102982	Pteropus vampyrus	87.75	0.00e+00	853.00
IUUC-Pgr-103551	Puccinia graminis	38.46	8.00e-08	50.80
IUUC-Ptt-103977	Puccinia triticina	32.89	7.00e-08	50.80
IUUC-Rno-105730	Rattus norvegicus	95.64	0.00e+00	857.00
IUUC-Sha-106588	Sarcophilus harrisii	70.36	2.00e-173	603.00
IUUC-Sja-107735	Schizosaccharomyces japonicus	35.38	2.00e-07	49.30
IUUC-Smo-109039	Selaginella moellendorffii	25.08	3.00e-18	85.90
IUUC-Sly-111835	Solanum lycopersicum	42.37	2.00e-08	55.50
IUUC-Stu-112898	Solanum tuberosum	42.37	2.00e-08	55.10
IUUC-Sar-113622	Sorex araneus	86.74	7.00e-153	535.00
IUUC-Sre-115041	Sporisorium reilianum	37.84	1.00e-09	57.00
IUUC-Ssc-115244	Sus scrofa	87.75	0.00e+00	827.00
IUUC-Tgu-117180	Taeniopygia guttata	64.63	2.00e-166	579.00
IUUC-Tru-118393	Takifugu rubripes	55.27	3.00e-120	426.00
IUUC-Tsy-119408	Tarsius syrichta	89.58	0.00e+00	871.00
IUUC-Tni-120664	Tetraodon nigroviridis	55.56	3.00e-119	422.00
IUUC-Tca-121712	Theobroma cacao	27.50	9.00e-17	80.90
IUUC-Tae-122787	Triticum aestivum	38.57	1.00e-10	60.50
IUUC-Tbe-127301	Tupaia belangeri	79.27	0.00e+00	764.00
IUUC-Ttr-128204	Tursiops truncatus	87.63	0.00e+00	877.00
IUUC-Uma-129420	Ustilago maydis	43.06	1.00e-09	57.40
IUUC-Vpa-130297	Vicugna pacos	88.89	0.00e+00	835.00
IUUC-Vvi-131157	Vitis vinifera	25.73	3.00e-17	82.40
IUUC-Xtr-132845	Xenopus tropicalis	65.16	2.00e-165	576.00
IUUC-Xma-133439	Xiphophorus maculatus	54.57	6.00e-107	382.00
IUUC-Yli-134652	Yarrowia lipolytica	38.78	5.00e-06	45.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence