iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005316

Ensembl Protein ID

ENSACAP00000011440.3

UniProt Accession

H9GHY8; H9GHY8_ANOCA

Protein Name

Uncharacterized protein

Gene Name

EML2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011527.3	ENSACAT00000011679.3	ENSACAP00000011440.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-22	77.9	523	560
UBD/Beta-Prp	3.50e-44	151.1	521	703

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHt++ ++la  ++ + +++++ D+++++W++ t+ +l
   Q: 523  GHTEELWGLAThPTlDQFLTCGQDKQVHLWSVATHQPL 560
           89*******99999999***************998765 PP

UBD/Beta-Prp

   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           ++gh+++++ l+ +p+ d +++ ++d+ +++w + t q l    +g d++ +++ +hp+g++lv G+  +   + d +t +l++  t  
   Q: 521  VQGHTEELWGLATHPTLDQFLTCGQDKQVHLWSVATHQPL--WSKGIDDAARSAGFHPSGSVLVVGTVTGRWLVLDTETRDLVTIHTD- 606
           6788888888888888888888888888888888888888..4788888888888888888888888888888888888888888876. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlq....tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
             +++  +sf+++gk+l+ gs+d+ v ++ ++    + + v ++ gh+++++ ++   ++  lv+ s D  i  Wd  +   +++ +  
   Q: 607  GGEQISVVSFSPDGKYLALGSHDNFVYIYLVSeggrKYSRVGKCSGHSSFITHLDWAYDSSCLVTNSGDYEILYWDPSTCRQITSAEAV 695
           77888888888888888888888888888888554444448888888888888888888888888888888888875554444444444 PP
   S: 264  nssvisva 271
           ++  ++ a
   Q: 696  RNMEWATA 703
           45555554 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKGTWPRAEA SMTDDNLSGV SGMEVDDRIS YLEQRLQLQE DEIQVLKAAL ADVLRRLSTC 60
EENGLSLQKK GPNKVYQLLR GLPSRPSLSN GIIPQRRGYS TSPSSPKREL LSGKSGRSSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGATGGCCC AGCCTGTGGG TGGCCGTGCC CACCCCTCCG CCCTCTCCCT CGCCCACTCT 60
CCTTCTCTCC AAGCTGGTTC TCTGCCTGGA TGCAGCGCCC GCTGCCTGTG ATTGGACCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005108--HELP
IPR023302--Pept_S9A_N
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015630--C:microtubule cytoskeleton
GO:0072686--C:mitotic spindle
GO:0008017--F:microtubule binding
GO:0031115--P:negative regulation of microtubule polymerization
GO:0010968--P:regulation of microtubule nucleation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002155	Ailuropoda melanoleuca	75.53	0.00e+00	1162.00
IUUC-Ame-011647	Astyanax mexicanus	69.60	0.00e+00	1084.00
IUUC-Bta-013267	Bos taurus	76.12	0.00e+00	1164.00
IUUC-Cel-018623	Caenorhabditis elegans	28.97	3.00e-80	293.00
IUUC-Cfa-020267	Canis familiaris	76.35	0.00e+00	1169.00
IUUC-Cin-025784	Ciona intestinalis	54.43	0.00e+00	741.00
IUUC-Csv-026305	Ciona savignyi	48.11	0.00e+00	759.00
IUUC-Dre-028734	Danio rerio	69.80	0.00e+00	1110.00
IUUC-Dno-028961	Dasypus novemcinctus	74.62	0.00e+00	1115.00
IUUC-Dme-032093	Drosophila melanogaster	37.44	9.00e-115	408.00
IUUC-Eca-033785	Equus caballus	75.60	0.00e+00	1159.00
IUUC-Eeu-035302	Erinaceus europaeus	80.65	0.00e+00	629.00
IUUC-Fca-036170	Felis catus	75.28	0.00e+00	1156.00
IUUC-Gac-042643	Gasterosteus aculeatus	65.98	0.00e+00	1033.00
IUUC-Ggo-044669	Gorilla gorilla	75.26	0.00e+00	1137.00
IUUC-Hsa-046141	Homo sapiens	76.91	0.00e+00	1179.00
IUUC-Itr-048788	Ictidomys tridecemlineatus	75.66	0.00e+00	1148.00
IUUC-Loc-052518	Lepisosteus oculatus	69.67	0.00e+00	1073.00
IUUC-Laf-054137	Loxodonta africana	76.24	0.00e+00	1013.00
IUUC-Mcc-055780	Macaca mulatta	81.62	0.00e+00	1045.00
IUUC-Meu-056664	Macropus eugenii	77.10	0.00e+00	1047.00
IUUC-Mmr-060853	Microcebus murinus	75.91	0.00e+00	1164.00
IUUC-Mdo-062224	Monodelphis domestica	76.12	0.00e+00	1035.00
IUUC-Mmu-063860	Mus musculus	75.56	0.00e+00	1167.00
IUUC-Mpu-066043	Mustela putorius furo	76.35	0.00e+00	1170.00
IUUC-Mlu-067125	Myotis lucifugus	61.36	0.00e+00	818.00
IUUC-Nle-069618	Nomascus leucogenys	68.96	0.00e+00	1004.00
IUUC-Opr-070228	Ochotona princeps	74.14	0.00e+00	988.00
IUUC-Ont-071258	Oreochromis niloticus	67.59	0.00e+00	1068.00
IUUC-Oga-088048	Otolemur garnettii	73.09	0.00e+00	1098.00
IUUC-Oar-089907	Ovis aries	80.99	0.00e+00	1084.00
IUUC-Pan-092082	Papio anubis	76.47	0.00e+00	1167.00
IUUC-Pma-094555	Petromyzon marinus	58.57	0.00e+00	813.00
IUUC-Pfo-096717	Poecilia formosa	66.62	0.00e+00	1057.00
IUUC-Pab-097619	Pongo abelii	81.46	0.00e+00	1112.00
IUUC-Pca-101070	Procavia capensis	70.56	0.00e+00	929.00
IUUC-Rno-105074	Rattus norvegicus	79.44	0.00e+00	1077.00
IUUC-Sha-106692	Sarcophilus harrisii	75.17	0.00e+00	1124.00
IUUC-Tru-117809	Takifugu rubripes	64.91	0.00e+00	1070.00
IUUC-Tni-120815	Tetraodon nigroviridis	66.17	0.00e+00	1085.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence