iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-072976

Ensembl Protein ID

ENSOANP00000000957.1

UniProt Accession

F7F3L2; F7F3L2_ORNAN

Protein Name

Uncharacterized protein

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000000608.2	ENSOANT00000000958.2	ENSOANP00000000957.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-37	125.6	130	187

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kG+v++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ 
   Q: 130  LHVVQALYPFSSSNDEELNFEKGEVMDVIEKPENDPEWWKC-KKGNGQVGLVPKNYVTV 187
           689**************************************.69*************86 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

IPWILSMVLK SFLGIGKVKR KPSVPDSACP ADDGFADAGE RLYDLNVPAY VKFSYMAERE 60
DELSLTKGTK VIVMEKCSDG WWRGSYNGQV GWFPSNYVTE EGDGPPGDHV GSLSEKLAAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCCCTGGA TTCTATCTAT GGTGCTTAAG TCGTTTTTGG CCATCTGCCT CCGCCGACTA 60
GACCGTGAGC CCGGCAGTGG GCGGGGATGG TCTCCATCCG TTGCCGAATT GTACATTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	89.25	3.00e-157	546.00
IUUC-Ago-007861	Ashbya gossypii	41.03	2.00e-05	42.40
IUUC-Ame-011235	Astyanax mexicanus	75.40	9.00e-139	485.00
IUUC-Bta-013039	Bos taurus	89.25	3.00e-157	546.00
IUUC-Cja-019546	Callithrix jacchus	88.60	8.00e-155	539.00
IUUC-Cfa-020462	Canis familiaris	89.25	3.00e-157	547.00
IUUC-Cpo-022009	Cavia porcellus	89.25	1.00e-157	548.00
IUUC-Csa-023875	Chlorocebus sabaeus	90.23	1.00e-157	548.00
IUUC-Cho-024368	Choloepus hoffmanni	89.54	3.00e-156	543.00
IUUC-Csv-026046	Ciona savignyi	40.12	8.00e-57	213.00
IUUC-Dre-028407	Danio rerio	75.08	6.00e-138	483.00
IUUC-Dno-029593	Dasypus novemcinctus	87.65	2.00e-118	417.00
IUUC-Dor-030730	Dipodomys ordii	87.24	3.00e-128	450.00
IUUC-Dme-031846	Drosophila melanogaster	43.96	2.00e-73	269.00
IUUC-Ete-032906	Echinops telfairi	87.95	2.00e-153	534.00
IUUC-Eca-033378	Equus caballus	89.25	3.00e-156	543.00
IUUC-Eeu-034743	Erinaceus europaeus	89.69	9.00e-142	495.00
IUUC-Fca-035745	Felis catus	89.25	8.00e-167	578.00
IUUC-Gac-042245	Gasterosteus aculeatus	72.41	7.00e-119	419.00
IUUC-Ggo-045487	Gorilla gorilla	90.23	1.00e-157	548.00
IUUC-Hsa-045902	Homo sapiens	90.23	1.00e-157	548.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	89.90	1.00e-157	548.00
IUUC-Lch-050165	Latimeria chalumnae	78.83	5.00e-138	483.00
IUUC-Loc-052523	Lepisosteus oculatus	78.32	3.00e-143	500.00
IUUC-Laf-053845	Loxodonta africana	88.93	3.00e-156	543.00
IUUC-Meu-056139	Macropus eugenii	86.64	1.00e-146	511.00
IUUC-Mmr-061108	Microcebus murinus	75.90	4.00e-119	420.00
IUUC-Mdo-062258	Monodelphis domestica	89.58	5.00e-159	553.00
IUUC-Mmu-063970	Mus musculus	88.93	9.00e-167	578.00
IUUC-Mpu-066093	Mustela putorius furo	88.60	5.00e-156	543.00
IUUC-Mlu-067193	Myotis lucifugus	89.25	4.00e-157	546.00
IUUC-Nle-069611	Nomascus leucogenys	90.23	1.00e-157	548.00
IUUC-Opr-070984	Ochotona princeps	88.70	1.00e-162	564.00
IUUC-Ont-072241	Oreochromis niloticus	73.75	3.00e-132	464.00
IUUC-Ocu-073905	Oryctolagus cuniculus	89.58	2.00e-157	547.00
IUUC-Ola-086513	Oryzias latipes	71.25	3.00e-118	417.00
IUUC-Oga-088588	Otolemur garnettii	89.58	5.00e-157	546.00
IUUC-Oar-089973	Ovis aries	89.25	3.00e-157	546.00
IUUC-Ptr-090968	Pan troglodytes	90.23	1.00e-157	548.00
IUUC-Pan-092840	Papio anubis	88.48	3.00e-119	420.00
IUUC-Pfo-096057	Poecilia formosa	71.43	5.00e-129	453.00
IUUC-Pab-097807	Pongo abelii	89.90	1.00e-157	548.00
IUUC-Pca-100522	Procavia capensis	86.83	1.00e-117	415.00
IUUC-Pva-103083	Pteropus vampyrus	89.58	2.00e-157	547.00
IUUC-Rno-104839	Rattus norvegicus	89.22	4.00e-166	576.00
IUUC-Sha-107294	Sarcophilus harrisii	89.25	1.00e-157	548.00
IUUC-Sar-113675	Sorex araneus	87.62	1.00e-153	535.00
IUUC-Ssc-116442	Sus scrofa	87.62	9.00e-165	572.00
IUUC-Tru-118058	Takifugu rubripes	69.72	2.00e-128	451.00
IUUC-Tsy-119184	Tarsius syrichta	85.81	4.00e-145	506.00
IUUC-Tni-119974	Tetraodon nigroviridis	72.67	9.00e-118	416.00
IUUC-Ttr-129155	Tursiops truncatus	87.62	7.00e-155	539.00
IUUC-Uma-129502	Ustilago maydis	25.64	8.00e-08	52.80
IUUC-Vpa-130344	Vicugna pacos	88.93	5.00e-157	546.00
IUUC-Xtr-132372	Xenopus tropicalis	84.36	1.00e-148	518.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence