iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115451

Ensembl Protein ID

ENSSSCP00000027982.1

UniProt Accession

Q6J1I8; RN114_PIG

Genbank Protein ID

AAT36620.1

Protein Name

E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 313

Genbank Nucleotide ID

AY606064

Gene Name

RNF114; ZNF313

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000027742.1	ENSSSCT00000025741.1	ENSSSCP00000027982.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.58	2.00e-102	368.00	IUUC-Hsa-046280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sus scrofa

Functional Description
(View)

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Protein Sequence
(Fasta)

FCSACLQECL KPKKPVCGVC RSTLAPGVRA VELERQIEST ETSCHGCRKN FFLSKIRAHV 60
ATCSKYQNYI MEGVKATTKD ASLQPRNVPN RYTFPCPYCP EKNFDQEGLV EHCKLVHSTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTGCTCT GCATGCCTGC AGGAATGTCT GAAGCCGAAG AAGCCTGTCT GTGGGGTGTG 60
TCGCAGCACT CTGGCCCCTG GTGTCCGAGC CGTGGAGCTC GAGCGGCAGA TTGAGAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis

KEGG

ssc:414917

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002315	Ailuropoda melanoleuca	96.69	4.00e-105	373.00
IUUC-Apl-004036	Anas platyrhynchos	76.24	9.00e-83	298.00
IUUC-Aca-004569	Anolis carolinensis	75.69	3.00e-84	303.00
IUUC-Ame-011339	Astyanax mexicanus	44.97	1.00e-42	165.00
IUUC-Bta-013345	Bos taurus	95.58	5.00e-104	369.00
IUUC-Cja-019919	Callithrix jacchus	96.13	1.00e-104	372.00
IUUC-Cfa-021164	Canis familiaris	97.24	2.00e-105	374.00
IUUC-Cpo-022051	Cavia porcellus	91.16	4.00e-99	353.00
IUUC-Csa-023956	Chlorocebus sabaeus	95.03	8.00e-103	365.00
IUUC-Dre-027499	Danio rerio	53.33	5.00e-58	216.00
IUUC-Dno-029437	Dasypus novemcinctus	97.24	2.00e-105	374.00
IUUC-Dor-030428	Dipodomys ordii	95.42	7.00e-87	312.00
IUUC-Ete-032855	Echinops telfairi	74.59	4.00e-69	253.00
IUUC-Eca-034236	Equus caballus	97.24	6.00e-105	372.00
IUUC-Eeu-034875	Erinaceus europaeus	98.12	2.00e-92	330.00
IUUC-Fca-036017	Felis catus	97.24	3.00e-105	374.00
IUUC-Fal-037133	Ficedula albicollis	76.24	7.00e-85	306.00
IUUC-Gga-040752	Gallus gallus	74.59	5.00e-82	296.00
IUUC-Gac-042409	Gasterosteus aculeatus	37.36	5.00e-24	103.00
IUUC-Ggo-044654	Gorilla gorilla	94.66	6.00e-74	268.00
IUUC-Hsa-046280	Homo sapiens	95.58	3.00e-103	367.00
IUUC-Itr-048594	Ictidomys tridecemlineatus	95.16	1.00e-104	371.00
IUUC-Lch-050028	Latimeria chalumnae	64.64	4.00e-69	253.00
IUUC-Loc-051797	Lepisosteus oculatus	59.67	4.00e-61	227.00
IUUC-Laf-054248	Loxodonta africana	95.58	1.00e-104	371.00
IUUC-Mcc-054724	Macaca mulatta	95.03	8.00e-103	365.00
IUUC-Meu-056464	Macropus eugenii	59.67	7.00e-53	199.00
IUUC-Mga-059403	Meleagris gallopavo	73.57	4.00e-62	229.00
IUUC-Mmr-061582	Microcebus murinus	97.24	5.00e-106	375.00
IUUC-Mdo-062106	Monodelphis domestica	80.11	4.00e-82	296.00
IUUC-Mmu-064176	Mus musculus	92.27	1.00e-92	332.00
IUUC-Mpu-066083	Mustela putorius furo	96.69	4.00e-105	373.00
IUUC-Mlu-067060	Myotis lucifugus	96.13	1.00e-103	368.00
IUUC-Nle-069353	Nomascus leucogenys	95.03	2.00e-93	334.00
IUUC-Opr-070916	Ochotona princeps	91.16	9.00e-100	355.00
IUUC-Ont-072284	Oreochromis niloticus	58.01	1.00e-62	232.00
IUUC-Oan-072858	Ornithorhynchus anatinus	77.35	2.00e-83	300.00
IUUC-Ocu-074471	Oryctolagus cuniculus	96.69	5.00e-105	373.00
IUUC-Ola-087569	Oryzias latipes	57.22	9.00e-63	232.00
IUUC-Olu-087618	Ostreococcus lucimarinus	40.91	2.00e-08	53.10
IUUC-Oga-089164	Otolemur garnettii	96.69	8.00e-105	372.00
IUUC-Oar-089436	Ovis aries	95.58	3.00e-104	370.00
IUUC-Ptr-090945	Pan troglodytes	95.58	3.00e-103	367.00
IUUC-Pan-092765	Papio anubis	95.03	8.00e-103	365.00
IUUC-Psi-093593	Pelodiscus sinensis	76.76	2.00e-65	239.00
IUUC-Pma-094178	Petromyzon marinus	45.90	2.00e-45	174.00
IUUC-Pfo-096157	Poecilia formosa	55.80	2.00e-60	224.00
IUUC-Pab-098509	Pongo abelii	95.03	7.00e-103	365.00
IUUC-Pca-100293	Procavia capensis	91.16	4.00e-96	343.00
IUUC-Pva-102556	Pteropus vampyrus	95.58	3.00e-104	370.00
IUUC-Rno-105634	Rattus norvegicus	91.16	1.00e-90	325.00
IUUC-Sha-107052	Sarcophilus harrisii	78.57	8.00e-79	286.00
IUUC-Sar-113680	Sorex araneus	93.37	5.00e-93	332.00
IUUC-Tgu-116515	Taeniopygia guttata	75.96	2.00e-84	304.00
IUUC-Tru-117712	Takifugu rubripes	57.22	4.00e-62	230.00
IUUC-Tsy-119419	Tarsius syrichta	96.69	5.00e-105	372.00
IUUC-Tni-119774	Tetraodon nigroviridis	57.78	2.00e-61	228.00
IUUC-Tbe-127924	Tupaia belangeri	93.33	2.00e-97	347.00
IUUC-Ttr-128721	Tursiops truncatus	97.24	5.00e-106	376.00
IUUC-Vpa-130175	Vicugna pacos	73.48	7.00e-73	266.00
IUUC-Xtr-131851	Xenopus tropicalis	59.55	2.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence