iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	18835386

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.30e-40	139.3	266	427

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmelees...................................................... 37
           aDv+++++ +e++fah+i+La+sSs+Fy+lflme+ees                                                      
   Q: 266  ADVLFILQdQEHIFAHRIYLATSSSKFYDLFLMECEESpngsegacekekqsrdfqgrilsvdpeeereegppripqadqwkssnkslveal 357
           7******************************************************************************************* PP
   S: 38   ...................................ksklmveik.d..vqpevfrallkFlYtgkldene 69
                                              ++++m++++ d  vqp++fr+ll+FlYtg+lde+e
   Q: 358  gleaegavpetqtltgwskgfigmhremqvnpiskRMGPMTVVRmDasVQPGPFRTLLQFLYTGQLDEKE 427
           ********************************************989*********************97 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR 60
VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGGACCC AGAGCCGCCG CGGGAGCTTC CAGCGTCCCC AGGTAGCGCG GGCGTCGCGG 60
GGCGTGGCGG GGCGGGAGCG CGCCCGGGAG GAGCCGCGCC AGGGTGGGCG GGATTATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000210--BTB/POZ_dom
IPR027417--P-loop_NTPase
IPR011333--SKP1/BTB/POZ
IPR001806--Small_GTPase
IPR003578--Small_GTPase_Rho

PROSITE

PS50097--BTB
PS51420--RHO

Pfam

PF00651--BTB
PF00071--Ras

SMART

SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005525--F:GTP binding
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

hsa:9886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002036	Ailuropoda melanoleuca	93.41	0.00e+00	1266.00
IUUC-Apl-003214	Anas platyrhynchos	82.69	0.00e+00	1120.00
IUUC-Aca-005311	Anolis carolinensis	82.52	0.00e+00	1110.00
IUUC-Ame-010789	Astyanax mexicanus	75.18	0.00e+00	995.00
IUUC-Bta-013141	Bos taurus	93.70	0.00e+00	1232.00
IUUC-Cja-019750	Callithrix jacchus	95.83	0.00e+00	1279.00
IUUC-Cfa-021073	Canis familiaris	91.40	0.00e+00	1224.00
IUUC-Cpo-021477	Cavia porcellus	93.97	0.00e+00	1266.00
IUUC-Csa-023710	Chlorocebus sabaeus	97.99	0.00e+00	1310.00
IUUC-Cho-024768	Choloepus hoffmanni	91.46	0.00e+00	1068.00
IUUC-Csv-026261	Ciona savignyi	54.34	5.00e-50	190.00
IUUC-Dre-028133	Danio rerio	74.03	0.00e+00	984.00
IUUC-Dno-030090	Dasypus novemcinctus	92.39	0.00e+00	1252.00
IUUC-Dor-030420	Dipodomys ordii	88.61	0.00e+00	1157.00
IUUC-Dme-032175	Drosophila melanogaster	42.24	8.00e-124	437.00
IUUC-Ete-032797	Echinops telfairi	82.33	0.00e+00	1074.00
IUUC-Eca-034014	Equus caballus	93.97	0.00e+00	1251.00
IUUC-Eeu-034860	Erinaceus europaeus	88.50	2.00e-168	586.00
IUUC-Fca-035800	Felis catus	93.55	0.00e+00	1268.00
IUUC-Fal-037203	Ficedula albicollis	81.81	0.00e+00	1107.00
IUUC-Fox-037834	Fusarium oxysporum	33.33	9.00e-06	44.30
IUUC-Gmo-038758	Gadus morhua	70.68	0.00e+00	914.00
IUUC-Gga-041076	Gallus gallus	82.26	0.00e+00	1114.00
IUUC-Itr-048179	Ictidomys tridecemlineatus	92.53	0.00e+00	1046.00
IUUC-Loc-051913	Lepisosteus oculatus	75.86	0.00e+00	1022.00
IUUC-Laf-054001	Loxodonta africana	93.39	0.00e+00	1256.00
IUUC-Mcc-054968	Macaca mulatta	97.84	0.00e+00	1313.00
IUUC-Meu-056380	Macropus eugenii	82.84	0.00e+00	971.00
IUUC-Mmr-061412	Microcebus murinus	94.26	0.00e+00	1258.00
IUUC-Mdo-062950	Monodelphis domestica	81.23	0.00e+00	1052.00
IUUC-Mmu-064030	Mus musculus	88.79	0.00e+00	1229.00
IUUC-Mpu-065787	Mustela putorius furo	93.12	0.00e+00	1266.00
IUUC-Mlu-067478	Myotis lucifugus	93.29	0.00e+00	1259.00
IUUC-Nle-069107	Nomascus leucogenys	98.71	0.00e+00	1320.00
IUUC-Opr-070647	Ochotona princeps	86.80	0.00e+00	1152.00
IUUC-Oan-073091	Ornithorhynchus anatinus	84.45	0.00e+00	1150.00
IUUC-Ocu-074505	Oryctolagus cuniculus	94.68	0.00e+00	1273.00
IUUC-Oga-088516	Otolemur garnettii	93.53	0.00e+00	1265.00
IUUC-Oar-090360	Ovis aries	93.70	0.00e+00	1262.00
IUUC-Ptr-090670	Pan troglodytes	99.43	0.00e+00	1326.00
IUUC-Pan-091983	Papio anubis	97.99	0.00e+00	1310.00
IUUC-Psi-093257	Pelodiscus sinensis	82.12	0.00e+00	1159.00
IUUC-Pab-097809	Pongo abelii	99.14	0.00e+00	1325.00
IUUC-Pca-100528	Procavia capensis	92.11	0.00e+00	1092.00
IUUC-Pva-102587	Pteropus vampyrus	89.40	0.00e+00	1234.00
IUUC-Pte-104298	Pyrenophora teres	32.56	1.00e-06	48.10
IUUC-Rno-105337	Rattus norvegicus	87.80	0.00e+00	1222.00
IUUC-Sha-107644	Sarcophilus harrisii	86.10	0.00e+00	1154.00
IUUC-Sar-113152	Sorex araneus	90.26	0.00e+00	1199.00
IUUC-Tgu-117136	Taeniopygia guttata	82.26	0.00e+00	1115.00
IUUC-Tsy-119463	Tarsius syrichta	84.71	0.00e+00	751.00
IUUC-Tbe-127320	Tupaia belangeri	89.10	0.00e+00	1199.00
IUUC-Ttr-129079	Tursiops truncatus	94.13	0.00e+00	1273.00
IUUC-Vpa-130767	Vicugna pacos	84.67	0.00e+00	1112.00
IUUC-Xtr-132058	Xenopus tropicalis	80.14	0.00e+00	1070.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence