iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071464

Ensembl Protein ID

ENSONIP00000014199.1

UniProt Accession

I3JZA4; I3JZA4_ORENI

Genbank Protein ID

ENSONIP00000014199

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AERX01022591

Gene Name

usp20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000011281.1	ENSONIT00000014209.1	ENSONIP00000014199.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-110	368.3	149	679

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     +    ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CGGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 232
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+         + ++ e+ ++ d+s ++de                                        
   Q: 233  QQDTQEFLRCLMDQLHEELKEplsecsvgGDGSDGEDRRDGDRSPSEDEflscdsgsssdrgegggvgdselliqddsgavisekerlk 321
           *******************887766666633333333334444444444788888888889**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 322  errvpgsplrggsqemdedadvdtaaeegsperraedeeepaaspntevqkpdneasmaqpqstpcspvrtlqelhpklssspprsspl 410
           ***************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
                            a++kk+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+                
   Q: 411  rssgpaysfkkaqlllsARKKKQSHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssihqnlpvktgvcp 499
           *****************9**************************************************99888**************** PP
   S: 186  .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                            +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf  ++
   Q: 500  dtygsqgwisyimdsirrfvvscipswfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF--RH 586
           *************************************************************************************..99 PP
   S: 242  eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgs 328
           e + + ki+++v+fple Ld++pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++   +
   Q: 587  EVMYSFKISSHVSFPLEgLDMRPFLAKESPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN---A 670
           99*************************88887..9**************************78999*******************...* PP
   S: 329  taYvlfYkr 337
           +aYvlfY++
   Q: 671  EAYVLFYRK 679
           *******98 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MAEQDVCPHL DSIGEVTKED LLQKSKGTCQ SCGAGGPNLW ACLQNDCPYV GCGESYSDHS 60
TLHAQAKKHN LTVNLTTFRI WCYVCEREVF LEHRPALVPV PAAAHLCKAT EQETSPQTVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGAAATCGG AGCGCACTTT GCGGTTTATG AATCTCTATG TATCAGTATA TACAAATAAA 60
ATAGTTGTGA ATCAAATGTT AATCAGGACA CAGAACTAAT ATTAAAAAAA GAAGAGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	74.97	0.00e+00	1344.00
IUUC-Apl-003351	Anas platyrhynchos	77.25	0.00e+00	1402.00
IUUC-Aca-005077	Anolis carolinensis	71.68	0.00e+00	1043.00
IUUC-Ame-011777	Astyanax mexicanus	83.79	0.00e+00	1482.00
IUUC-Bta-013063	Bos taurus	76.58	0.00e+00	1382.00
IUUC-Cja-019868	Callithrix jacchus	75.30	0.00e+00	1381.00
IUUC-Cfa-020761	Canis familiaris	75.54	0.00e+00	1357.00
IUUC-Cpo-022267	Cavia porcellus	74.78	0.00e+00	1347.00
IUUC-Csa-024251	Chlorocebus sabaeus	75.82	0.00e+00	1384.00
IUUC-Cho-024483	Choloepus hoffmanni	91.98	8.00e-120	424.00
IUUC-Dre-028061	Danio rerio	73.53	0.00e+00	1326.00
IUUC-Dno-029423	Dasypus novemcinctus	76.28	0.00e+00	1390.00
IUUC-Dor-030877	Dipodomys ordii	76.08	0.00e+00	913.00
IUUC-Dme-031837	Drosophila melanogaster	49.89	3.00e-137	483.00
IUUC-Ete-032802	Echinops telfairi	64.39	7.00e-113	401.00
IUUC-Eca-034283	Equus caballus	74.35	0.00e+00	1340.00
IUUC-Eeu-034620	Erinaceus europaeus	72.17	0.00e+00	919.00
IUUC-Fca-036357	Felis catus	76.55	0.00e+00	1372.00
IUUC-Fal-037411	Ficedula albicollis	77.83	0.00e+00	1410.00
IUUC-Gmo-038563	Gadus morhua	81.14	0.00e+00	924.00
IUUC-Gga-041101	Gallus gallus	77.05	0.00e+00	1394.00
IUUC-Gac-041315	Gasterosteus aculeatus	89.37	0.00e+00	1576.00
IUUC-Ggo-045600	Gorilla gorilla	75.62	0.00e+00	1363.00
IUUC-Hsa-045825	Homo sapiens	76.03	0.00e+00	1378.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	66.60	0.00e+00	1150.00
IUUC-Lch-050002	Latimeria chalumnae	74.73	0.00e+00	1314.00
IUUC-Loc-052574	Lepisosteus oculatus	85.03	0.00e+00	1498.00
IUUC-Laf-054428	Loxodonta africana	75.03	0.00e+00	1376.00
IUUC-Mcc-055736	Macaca mulatta	75.71	0.00e+00	1383.00
IUUC-Mga-059781	Meleagris gallopavo	77.11	0.00e+00	1399.00
IUUC-Mmr-061328	Microcebus murinus	84.77	0.00e+00	830.00
IUUC-Mdo-063048	Monodelphis domestica	77.27	0.00e+00	1364.00
IUUC-Mmu-064079	Mus musculus	75.73	0.00e+00	1353.00
IUUC-Mpu-066616	Mustela putorius furo	75.43	0.00e+00	1387.00
IUUC-Mlu-067294	Myotis lucifugus	75.60	0.00e+00	1338.00
IUUC-Nle-070015	Nomascus leucogenys	75.93	0.00e+00	1373.00
IUUC-Opr-070328	Ochotona princeps	75.25	0.00e+00	1361.00
IUUC-Oan-073259	Ornithorhynchus anatinus	71.06	0.00e+00	1202.00
IUUC-Ocu-074630	Oryctolagus cuniculus	73.18	0.00e+00	1312.00
IUUC-Ola-087240	Oryzias latipes	90.77	0.00e+00	1536.00
IUUC-Oga-088761	Otolemur garnettii	75.95	0.00e+00	1392.00
IUUC-Oar-089490	Ovis aries	72.92	0.00e+00	1260.00
IUUC-Ptr-091662	Pan troglodytes	76.03	0.00e+00	1378.00
IUUC-Pan-092199	Papio anubis	75.54	0.00e+00	1372.00
IUUC-Psi-093726	Pelodiscus sinensis	77.80	0.00e+00	1398.00
IUUC-Pma-094389	Petromyzon marinus	61.69	7.00e-101	360.00
IUUC-Pfo-096522	Poecilia formosa	85.33	0.00e+00	1167.00
IUUC-Pab-098632	Pongo abelii	75.82	0.00e+00	1372.00
IUUC-Pca-100614	Procavia capensis	70.47	0.00e+00	1086.00
IUUC-Pva-102922	Pteropus vampyrus	69.06	0.00e+00	743.00
IUUC-Rno-105215	Rattus norvegicus	75.68	0.00e+00	1345.00
IUUC-Sce-106176	Saccharomyces cerevisiae	29.43	2.00e-23	104.00
IUUC-Sha-106601	Sarcophilus harrisii	75.71	0.00e+00	1347.00
IUUC-Ssc-115533	Sus scrofa	75.49	0.00e+00	1358.00
IUUC-Tgu-117364	Taeniopygia guttata	77.52	0.00e+00	1405.00
IUUC-Tru-117770	Takifugu rubripes	88.18	0.00e+00	1553.00
IUUC-Tni-120001	Tetraodon nigroviridis	88.19	0.00e+00	1514.00
IUUC-Ttr-128732	Tursiops truncatus	76.52	0.00e+00	1384.00
IUUC-Xtr-132157	Xenopus tropicalis	72.21	0.00e+00	1278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence