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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045688
Ensembl Protein ID ENSP00000358789.4
UniProt Accession Q5TCZ1; D3DR98; O43302; Q5TCZ2; Q5TDQ8; SPD2A_HUMAN
Genbank Protein ID BAA24848.2; CAI13961.1; CAI13961.1; CAI13962.1; CAI13962.1; CAI13963.1; CAI15351.1; CAI15351.1; CAI15352.1; CAI15352.1; EAW49623.1; EAW49624.1
Protein Name SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
Genbank Nucleotide ID AB007878; AL121929; AL133355; AL121929; AL133355; AL121929; AL133355; AL121929; AL133355; AL121929; CH471066; CH471066
Gene Name SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107957.16 ENST00000369774.8 ENSP00000358789.4
ENSG00000107957.16 ENST00000420222.1 ENSP00000395781.1
ENSG00000107957.16 ENST00000355946.6 ENSP00000348215.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.30e-24 86.8 172 221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            v  +y+ q++ eL+l++G+vv+vi  e+++ gW+     +++ +G +P+ + e
   Q: 172  VVVSNYKKQENSELSLQAGEVVDVI--EKNESGWWFV--STSEEQGWVPATYLE 221
           55668999*****************..9999****87..89********99976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
 Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
Protein Sequence
(Fasta)
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL QMQLLDKFPI 60
EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY CRALVRLPPH ISQCDEVFRF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045688|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGCGGGC GAGCGCAGCG CGGCGGCCGC GCGGGAGTGA AGGGGCGCGC GGCAGGCCGG 60
CGGGGAGTCC CCCGGGGCGC ACGGAGCCCG CGCGCCCTCC GGGACCCTCC CCCGTCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045688|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR001683--Phox
IPR001452--SH3_domain
PROSITE

PS50195--PX
PS50002--SH3
Pfam

PF00787--PX
PF00018--SH3_1
SMART

SM00312--PX
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0035091--F:phosphatidylinositol binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0072675--P:osteoclast fusion
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:0006801--P:superoxide metabolic process
KEGG hsa:9644
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002151 Ailuropoda melanoleuca 88.70 0.00e+00 1463.00
IUUC-Apl-003703 Anas platyrhynchos 74.51 0.00e+00 1290.00
IUUC-Aca-004457 Anolis carolinensis 81.91 0.00e+00 627.00
IUUC-Ago-007743 Ashbya gossypii 33.06 6.00e-12 65.90
IUUC-Acl-008171 Aspergillus clavatus 34.17 3.00e-14 73.60
IUUC-Afl-008719 Aspergillus flavus 35.00 3.00e-14 73.60
IUUC-Afu-008915 Aspergillus fumigatus 35.00 4.00e-15 76.60
IUUC-Ani-009427 Aspergillus nidulans 35.00 7.00e-15 75.90
IUUC-Ang-009708 Aspergillus niger 33.33 1.00e-13 71.60
IUUC-Aor-010013 Aspergillus oryzae 35.00 3.00e-14 73.60
IUUC-Ate-010261 Aspergillus terreus 33.33 2.00e-13 71.20
IUUC-Ame-011457 Astyanax mexicanus 64.10 0.00e+00 761.00
IUUC-Bta-013479 Bos taurus 88.13 0.00e+00 1492.00
IUUC-Cja-019155 Callithrix jacchus 93.65 0.00e+00 1766.00
IUUC-Cfa-020490 Canis familiaris 92.33 0.00e+00 1718.00
IUUC-Cpo-021684 Cavia porcellus 90.82 0.00e+00 1796.00
IUUC-Csa-023923 Chlorocebus sabaeus 96.17 0.00e+00 1670.00
IUUC-Dre-028235 Danio rerio 64.77 0.00e+00 764.00
IUUC-Dno-029730 Dasypus novemcinctus 90.79 0.00e+00 1378.00
IUUC-Dor-030418 Dipodomys ordii 85.06 0.00e+00 1586.00
IUUC-Dse-031199 Dothistroma septosporum 32.79 2.00e-13 70.90
IUUC-Eca-034227 Equus caballus 93.90 0.00e+00 1782.00
IUUC-Eeu-034576 Erinaceus europaeus 85.64 0.00e+00 811.00
IUUC-Fca-036401 Felis catus 90.10 0.00e+00 1319.00
IUUC-Fal-037241 Ficedula albicollis 75.25 0.00e+00 1406.00
IUUC-Gmo-038635 Gadus morhua 65.57 0.00e+00 716.00
IUUC-Gga-040247 Gallus gallus 76.25 0.00e+00 1549.00
IUUC-Gac-042274 Gasterosteus aculeatus 68.45 0.00e+00 819.00
IUUC-Ggo-044416 Gorilla gorilla 99.65 0.00e+00 2030.00
IUUC-Itr-048267 Ictidomys tridecemlineatus 90.31 0.00e+00 1537.00
IUUC-Lch-049929 Latimeria chalumnae 67.74 0.00e+00 1368.00
IUUC-Loc-052462 Lepisosteus oculatus 63.92 0.00e+00 1231.00
IUUC-Lma-053176 Leptosphaeria maculans 33.65 1.00e-13 72.40
IUUC-Laf-053739 Loxodonta africana 93.24 0.00e+00 1829.00
IUUC-Mcc-055016 Macaca mulatta 99.21 0.00e+00 2018.00
IUUC-Meu-056030 Macropus eugenii 81.84 0.00e+00 1712.00
IUUC-Mga-059413 Meleagris gallopavo 75.30 0.00e+00 1276.00
IUUC-Mvi-060253 Microbotryum violaceum 28.91 3.00e-11 64.30
IUUC-Mmr-061087 Microcebus murinus 95.06 0.00e+00 1924.00
IUUC-Mdo-062381 Monodelphis domestica 82.54 0.00e+00 1692.00
IUUC-Mmu-063918 Mus musculus 91.09 0.00e+00 1820.00
IUUC-Mpu-065765 Mustela putorius furo 91.17 0.00e+00 1816.00
IUUC-Mlu-067569 Myotis lucifugus 93.11 0.00e+00 1707.00
IUUC-Nfi-068447 Neosartorya fischeri 35.00 4.00e-15 76.60
IUUC-Ncr-068701 Neurospora crassa 34.62 1.00e-14 75.10
IUUC-Nle-069525 Nomascus leucogenys 98.94 0.00e+00 1953.00
IUUC-Opr-070295 Ochotona princeps 91.01 0.00e+00 1827.00
IUUC-Ont-071453 Oreochromis niloticus 65.77 0.00e+00 754.00
IUUC-Oan-073433 Ornithorhynchus anatinus 70.33 0.00e+00 1150.00
IUUC-Ocu-074937 Oryctolagus cuniculus 90.82 0.00e+00 1706.00
IUUC-Ola-087466 Oryzias latipes 65.05 0.00e+00 749.00
IUUC-Oga-088137 Otolemur garnettii 93.62 0.00e+00 1712.00
IUUC-Oar-089419 Ovis aries 87.66 0.00e+00 1528.00
IUUC-Pan-092312 Papio anubis 98.86 0.00e+00 1519.00
IUUC-Psi-093083 Pelodiscus sinensis 79.16 0.00e+00 687.00
IUUC-Pma-094308 Petromyzon marinus 54.51 1.00e-148 521.00
IUUC-Pno-095129 Phaeosphaeria nodorum 31.73 5.00e-12 66.20
IUUC-Pfo-096570 Poecilia formosa 65.85 0.00e+00 769.00
IUUC-Pab-098178 Pongo abelii 95.94 0.00e+00 1947.00
IUUC-Pca-100175 Procavia capensis 86.67 0.00e+00 909.00
IUUC-Pva-102477 Pteropus vampyrus 90.59 0.00e+00 1842.00
IUUC-Pte-104254 Pyrenophora teres 34.31 1.00e-13 71.60
IUUC-Pyt-104756 Pyrenophora triticirepentis 33.65 9.00e-14 72.00
IUUC-Rno-105320 Rattus norvegicus 90.29 0.00e+00 1821.00
IUUC-Sha-106782 Sarcophilus harrisii 82.12 0.00e+00 1639.00
IUUC-Sja-107854 Schizosaccharomyces japonicus 32.54 6.00e-12 65.90
IUUC-Ssc-116136 Sus scrofa 93.30 0.00e+00 1607.00
IUUC-Tgu-116879 Taeniopygia guttata 73.45 0.00e+00 1231.00
IUUC-Tru-117609 Takifugu rubripes 65.15 0.00e+00 774.00
IUUC-Tni-119718 Tetraodon nigroviridis 64.54 0.00e+00 727.00
IUUC-Tbe-128042 Tupaia belangeri 86.94 0.00e+00 1063.00
IUUC-Ttr-129158 Tursiops truncatus 86.42 0.00e+00 971.00
IUUC-Xtr-132901 Xenopus tropicalis 68.19 0.00e+00 1291.00
IUUC-Xma-133284 Xiphophorus maculatus 66.72 0.00e+00 797.00
IUUC-Yli-134532 Yarrowia lipolytica 32.17 6.00e-12 66.20
Created Date 25-Jun-2017

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