• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046621
UUCD1 version UUC-HoS-00172
Ensembl Protein ID ENSP00000343930.3
UniProt Accession Q6TDP4; Q5SV94; KLH17_HUMAN
Genbank Protein ID AAR03710.1; ENSP00000343930
Protein Name Kelch-like protein 17; Actinfilin
Genbank Nucleotide ID AY423763; AL645608
Gene Name KLHL17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000187961.13 ENST00000338591.7 ENSP00000343930.3
ENSG00000187961.13 ENST00000466300.1 ENSP00000463694.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 17062563
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 5.90e-21 76.3 92 156
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.00e-13 48.0 191 221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D++l+v+ +e++ahk+vLa++S++F+a+f++e++es+ +  v+++d++p+++ +l++F Yt ++ 
   Q: 92   CDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR-QTHVTLHDIDPQALDQLVQFAYTAEIV 156
           8*************************************.***********************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi+ fAd+++c+dL +aa++++l+hF
   Q: 191  PSNCLGIRGFADAHSCSDLLKAAHRYVLQHF 221
           89***************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).
 Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).
Protein Sequence
(Fasta)
MQPRSERPAG RTQSPEHGSP GPGPEAPPPP PPQPPAPEAE RTRPRQARPA APMEGAVQLL 60
SREGHSVAHN SKRHYHDAFV AMSRMRQRGL LCDIVLHVAA KEIRAHKVVL ASCSPYFHAM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046621|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGAGCGAC ACAGAGCGGG CCGCCACCGC CGAGCAGCCC TCCGGCAGTC TCCGCGTCCG 60
TTAAGCCCGC GGGTCCTCCG CGAATCGGCG GTGGGTCCGG CAGCCGAATG CAGCCCCGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046621|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030054--C:cell junction
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0032839--C:dendrite cytoplasm
GO:0005615--C:extracellular space
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0051015--F:actin filament binding
GO:0032947--F:protein complex scaffold
GO:0030036--P:actin cytoskeleton organization
GO:0007420--P:brain development
GO:0016567--P:protein ubiquitination
KEGG hsa:339451
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002095 Ailuropoda melanoleuca 98.26 0.00e+00 1128.00
IUUC-Apl-003315 Anas platyrhynchos 79.90 0.00e+00 937.00
IUUC-Aca-005317 Anolis carolinensis 89.80 0.00e+00 1073.00
IUUC-Ame-010707 Astyanax mexicanus 89.74 0.00e+00 1058.00
IUUC-Bta-012531 Bos taurus 96.50 0.00e+00 1146.00
IUUC-Bra-017070 Brassica rapa 30.85 4.00e-17 83.20
IUUC-Cfa-021138 Canis familiaris 95.22 0.00e+00 1151.00
IUUC-Cpo-021432 Cavia porcellus 96.01 0.00e+00 1192.00
IUUC-Csa-023772 Chlorocebus sabaeus 99.65 0.00e+00 1155.00
IUUC-Dre-028401 Danio rerio 89.74 0.00e+00 1058.00
IUUC-Dno-029729 Dasypus novemcinctus 94.88 0.00e+00 1101.00
IUUC-Dor-030659 Dipodomys ordii 97.91 0.00e+00 1120.00
IUUC-Dme-031996 Drosophila melanogaster 56.17 0.00e+00 647.00
IUUC-Ete-033128 Echinops telfairi 92.24 0.00e+00 855.00
IUUC-Eca-033856 Equus caballus 97.22 0.00e+00 1105.00
IUUC-Eeu-034646 Erinaceus europaeus 92.64 0.00e+00 1033.00
IUUC-Fca-036183 Felis catus 97.74 0.00e+00 1120.00
IUUC-Fal-037046 Ficedula albicollis 81.21 0.00e+00 865.00
IUUC-Gmo-039526 Gadus morhua 83.07 0.00e+00 965.00
IUUC-Gga-040510 Gallus gallus 91.33 0.00e+00 1075.00
IUUC-Gac-042529 Gasterosteus aculeatus 86.93 0.00e+00 1046.00
IUUC-Ggo-044992 Gorilla gorilla 100.00 0.00e+00 1212.00
IUUC-Itr-048791 Ictidomys tridecemlineatus 95.37 0.00e+00 1152.00
IUUC-Lch-049449 Latimeria chalumnae 90.09 0.00e+00 1063.00
IUUC-Loc-052690 Lepisosteus oculatus 84.99 0.00e+00 1046.00
IUUC-Laf-053925 Loxodonta africana 96.29 0.00e+00 702.00
IUUC-Mcc-054780 Macaca mulatta 89.49 0.00e+00 1080.00
IUUC-Meu-056812 Macropus eugenii 84.72 0.00e+00 826.00
IUUC-Mpo-057526 Magnaporthe poae 27.50 3.00e-07 48.50
IUUC-Mga-059704 Meleagris gallopavo 90.85 0.00e+00 1076.00
IUUC-Mmr-061724 Microcebus murinus 95.45 0.00e+00 1130.00
IUUC-Mmu-063886 Mus musculus 96.01 0.00e+00 1147.00
IUUC-Mpu-066774 Mustela putorius furo 98.26 0.00e+00 1128.00
IUUC-Nle-070159 Nomascus leucogenys 99.68 0.00e+00 1209.00
IUUC-Opr-070367 Ochotona princeps 90.32 0.00e+00 822.00
IUUC-Ont-071757 Oreochromis niloticus 89.04 0.00e+00 1051.00
IUUC-Ocu-074674 Oryctolagus cuniculus 90.70 0.00e+00 1021.00
IUUC-Ola-086760 Oryzias latipes 87.44 0.00e+00 1049.00
IUUC-Oga-088570 Otolemur garnettii 93.95 0.00e+00 1142.00
IUUC-Oar-090344 Ovis aries 85.58 0.00e+00 992.00
IUUC-Ptr-090946 Pan troglodytes 99.84 0.00e+00 1210.00
IUUC-Pan-092661 Papio anubis 99.65 0.00e+00 1155.00
IUUC-Psi-094009 Pelodiscus sinensis 88.05 0.00e+00 1043.00
IUUC-Ppa-095956 Physcomitrella patens 27.38 4.00e-16 79.70
IUUC-Pfo-097164 Poecilia formosa 83.71 0.00e+00 1039.00
IUUC-Pab-097554 Pongo abelii 69.74 0.00e+00 754.00
IUUC-Pca-100460 Procavia capensis 87.30 0.00e+00 1016.00
IUUC-Pva-102180 Pteropus vampyrus 97.61 0.00e+00 1150.00
IUUC-Rno-105907 Rattus norvegicus 96.01 0.00e+00 1147.00
IUUC-Smo-109299 Selaginella moellendorffii 27.16 5.00e-16 79.70
IUUC-Sar-113112 Sorex araneus 82.88 1.00e-180 625.00
IUUC-Ssc-115448 Sus scrofa 90.77 0.00e+00 829.00
IUUC-Tgu-117293 Taeniopygia guttata 91.22 0.00e+00 1077.00
IUUC-Tru-117814 Takifugu rubripes 87.18 0.00e+00 1030.00
IUUC-Tni-120531 Tetraodon nigroviridis 89.22 0.00e+00 1054.00
IUUC-Tca-120913 Theobroma cacao 34.26 9.00e-36 145.00
IUUC-Tae-124075 Triticum aestivum 33.84 7.00e-40 159.00
IUUC-Tbe-127460 Tupaia belangeri 98.36 0.00e+00 1078.00
IUUC-Ttr-129301 Tursiops truncatus 93.84 1.00e-137 483.00
IUUC-Xtr-132356 Xenopus tropicalis 91.30 0.00e+00 1073.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved