iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021957

Ensembl Protein ID

ENSCPOP00000002700.2

UniProt Accession

H0UZT1; H0UZT1_CAVPO

Genbank Protein ID

ENSCPOP00000002700

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAKN02015069

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000002973.3	ENSCPOT00000003012.2	ENSCPOP00000002700.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-27	95.0	274	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           kvC  C+++g+d+ ++++Ce C++ +H  Clk++  eelp ++ w C+ Cr +
   Q: 274  KVCQACRKPGNDS-KMLVCETCDKGYHTFCLKPP-MEELPAHS-WKCKACRVC 323
           58*********87.6*******************.*******8.******965 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MDGQKQPGED KDSEPAADGP AASEDPGATE PDLPNSHIGE VSDLCHGSPR LQEPPRDGSG 60
GLVRRCALCN CGEPSLHGQR ELRRFELPFD WPRSPVVAPG GNAGPSEAVL PSEDPSQIGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGCC AGAAGCAGCC TGGTGAGGAT AAAGATTCAG AACCGGCAGG TAAGTAGGAC 60
AAATTCTGTG TTTTCCAATG ACTCTTGATG GGTAACCTTA CATTATTGGT ACTGGCACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011990--TPR-like_helical_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	90.89	0.00e+00	3590.00
IUUC-Aca-005364	Anolis carolinensis	91.81	0.00e+00	1084.00
IUUC-Ame-010612	Astyanax mexicanus	81.00	0.00e+00	1006.00
IUUC-Bta-013011	Bos taurus	89.62	0.00e+00	3539.00
IUUC-Cja-019841	Callithrix jacchus	90.45	0.00e+00	3746.00
IUUC-Cfa-021131	Canis familiaris	91.47	0.00e+00	3645.00
IUUC-Csa-023722	Chlorocebus sabaeus	91.20	0.00e+00	3693.00
IUUC-Dno-029932	Dasypus novemcinctus	89.83	0.00e+00	1657.00
IUUC-Dor-030192	Dipodomys ordii	84.35	0.00e+00	1677.00
IUUC-Ete-032572	Echinops telfairi	90.00	0.00e+00	1489.00
IUUC-Eca-034166	Equus caballus	91.20	0.00e+00	731.00
IUUC-Eeu-034848	Erinaceus europaeus	92.58	0.00e+00	1345.00
IUUC-Fca-035424	Felis catus	91.25	0.00e+00	3645.00
IUUC-Fal-037179	Ficedula albicollis	67.28	0.00e+00	1172.00
IUUC-Gmo-038719	Gadus morhua	82.02	0.00e+00	907.00
IUUC-Gga-040815	Gallus gallus	58.32	0.00e+00	1920.00
IUUC-Gac-042436	Gasterosteus aculeatus	79.68	0.00e+00	992.00
IUUC-Ggo-044711	Gorilla gorilla	91.56	0.00e+00	3600.00
IUUC-Hsa-046567	Homo sapiens	91.47	0.00e+00	3660.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	91.59	0.00e+00	3663.00
IUUC-Loc-051979	Lepisosteus oculatus	82.64	0.00e+00	1056.00
IUUC-Laf-054377	Loxodonta africana	89.77	0.00e+00	3588.00
IUUC-Mcc-055577	Macaca mulatta	90.22	0.00e+00	3643.00
IUUC-Meu-055992	Macropus eugenii	84.74	0.00e+00	1316.00
IUUC-Mmr-061772	Microcebus murinus	87.61	0.00e+00	3628.00
IUUC-Mdo-062876	Monodelphis domestica	82.88	0.00e+00	1132.00
IUUC-Mmu-063903	Mus musculus	86.13	0.00e+00	3546.00
IUUC-Mpu-066700	Mustela putorius furo	90.43	0.00e+00	3550.00
IUUC-Mlu-068180	Myotis lucifugus	89.34	0.00e+00	3666.00
IUUC-Nle-069362	Nomascus leucogenys	91.52	0.00e+00	3584.00
IUUC-Opr-070304	Ochotona princeps	86.22	0.00e+00	3400.00
IUUC-Ont-071881	Oreochromis niloticus	64.36	0.00e+00	1393.00
IUUC-Ocu-074053	Oryctolagus cuniculus	86.16	0.00e+00	3682.00
IUUC-Ola-086384	Oryzias latipes	78.69	0.00e+00	1010.00
IUUC-Oga-088450	Otolemur garnettii	88.38	0.00e+00	3855.00
IUUC-Oar-089975	Ovis aries	93.75	0.00e+00	2017.00
IUUC-Ptr-091073	Pan troglodytes	91.28	0.00e+00	3682.00
IUUC-Pan-092871	Papio anubis	88.84	0.00e+00	3685.00
IUUC-Pfo-097525	Poecilia formosa	79.93	0.00e+00	977.00
IUUC-Pab-097679	Pongo abelii	91.81	0.00e+00	3670.00
IUUC-Pca-100499	Procavia capensis	88.92	0.00e+00	2183.00
IUUC-Pva-102898	Pteropus vampyrus	90.24	0.00e+00	3492.00
IUUC-Rno-105660	Rattus norvegicus	87.30	0.00e+00	3568.00
IUUC-Sha-107431	Sarcophilus harrisii	80.19	0.00e+00	3078.00
IUUC-Sbi-113816	Sorghum bicolor	31.07	2.00e-13	71.20
IUUC-Ssc-115678	Sus scrofa	91.00	0.00e+00	3452.00
IUUC-Tru-117922	Takifugu rubripes	80.21	0.00e+00	1008.00
IUUC-Tsy-118905	Tarsius syrichta	83.22	0.00e+00	1600.00
IUUC-Tbe-127625	Tupaia belangeri	87.14	5.00e-159	557.00
IUUC-Ttr-129162	Tursiops truncatus	89.20	0.00e+00	2079.00
IUUC-Xtr-132455	Xenopus tropicalis	63.78	0.00e+00	1301.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence