iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089675

Ensembl Protein ID

ENSOARP00000016018.1

UniProt Accession

W5PZY2; W5PZY2_SHEEP

Genbank Protein ID

ENSOARP00000016018

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01045657

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014927.1	ENSOART00000016252.1	ENSOARP00000016018.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-99	333.3	608	1278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 608  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 694
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 695  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 779
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 780  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 866
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 867  tllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypl 953
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 954  fvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqgpgcttllstssleagdsdrdpiqppelqlvtpvaegdtgasra 1040
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1041 waspdrgpvpstsgissemvaggpievgaltvgervsrpeaavpgyqhpsealsahtpqffiyridasnreqrledkgdvplelgdd 1127
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1128 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1214
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYv 296
           i++LkRfsf++  +++ kin+ vefp + Ldl +fc+ ++e+q    +Y+L+av++H+G++ +GHY+
   Q: 1215 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLGKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYT 1278
           ************8886.**********9**********99888..9********************8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

LVRLSVPCWR ICPQRVAKIA GPGRKRRSPD PDAVADPGAL WLSTKRLKMS GGASATGPRR 60
GPPGLEEATS KKKQKDRANQ ESKDGDPRRG GSGIPGAVGA FSSSLPIEHT HGGVGRRFFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGTTAGGC TGTCTGTTCC TTGCTGGAGA ATTTGTCCAC AAAGAGTTGC CAAGATAGCT 60
GGGCCAGGAA GAAAGCGTCG TAGCCCTGAC CCAGACGCCG TTGCCGACCC CGGGGCACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	82.87	0.00e+00	2178.00
IUUC-Apl-003368	Anas platyrhynchos	63.91	0.00e+00	1561.00
IUUC-Aca-004267	Anolis carolinensis	71.56	0.00e+00	1328.00
IUUC-Ame-010970	Astyanax mexicanus	69.00	0.00e+00	1177.00
IUUC-Bta-012905	Bos taurus	88.97	0.00e+00	2331.00
IUUC-Cja-018789	Callithrix jacchus	82.84	0.00e+00	2019.00
IUUC-Cfa-021004	Canis familiaris	83.48	0.00e+00	2184.00
IUUC-Cpo-021529	Cavia porcellus	81.35	0.00e+00	1955.00
IUUC-Csa-024035	Chlorocebus sabaeus	82.42	0.00e+00	2026.00
IUUC-Cho-025036	Choloepus hoffmanni	74.04	0.00e+00	1078.00
IUUC-Cin-025451	Ciona intestinalis	43.67	2.00e-85	310.00
IUUC-Csv-025931	Ciona savignyi	35.77	1.00e-99	357.00
IUUC-Dre-028556	Danio rerio	69.22	0.00e+00	1168.00
IUUC-Dno-029240	Dasypus novemcinctus	84.54	0.00e+00	1792.00
IUUC-Dor-030495	Dipodomys ordii	92.56	0.00e+00	1040.00
IUUC-Ete-032741	Echinops telfairi	85.17	0.00e+00	1584.00
IUUC-Eca-033661	Equus caballus	85.40	0.00e+00	2069.00
IUUC-Eeu-034648	Erinaceus europaeus	79.96	0.00e+00	699.00
IUUC-Fca-035646	Felis catus	83.08	0.00e+00	2154.00
IUUC-Fal-037094	Ficedula albicollis	78.30	0.00e+00	1362.00
IUUC-Gmo-038869	Gadus morhua	71.99	0.00e+00	766.00
IUUC-Gga-041170	Gallus gallus	76.67	0.00e+00	1328.00
IUUC-Gac-041901	Gasterosteus aculeatus	68.97	0.00e+00	1130.00
IUUC-Ggo-044708	Gorilla gorilla	83.83	0.00e+00	2048.00
IUUC-Hsa-046791	Homo sapiens	86.44	0.00e+00	1700.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	83.46	0.00e+00	1963.00
IUUC-Lch-050456	Latimeria chalumnae	65.30	0.00e+00	1012.00
IUUC-Loc-052861	Lepisosteus oculatus	59.90	0.00e+00	1065.00
IUUC-Laf-053788	Loxodonta africana	82.90	0.00e+00	1951.00
IUUC-Mcc-055693	Macaca mulatta	79.77	0.00e+00	2092.00
IUUC-Meu-055921	Macropus eugenii	83.60	0.00e+00	1298.00
IUUC-Mga-059879	Meleagris gallopavo	63.55	0.00e+00	1496.00
IUUC-Mmr-060802	Microcebus murinus	86.19	0.00e+00	2075.00
IUUC-Mdo-061856	Monodelphis domestica	82.16	0.00e+00	1351.00
IUUC-Mmu-063874	Mus musculus	82.37	0.00e+00	1968.00
IUUC-Mpu-066166	Mustela putorius furo	83.40	0.00e+00	2162.00
IUUC-Nle-070161	Nomascus leucogenys	84.45	0.00e+00	2093.00
IUUC-Opr-071015	Ochotona princeps	86.07	0.00e+00	1631.00
IUUC-Ont-072308	Oreochromis niloticus	63.52	0.00e+00	1191.00
IUUC-Oan-072723	Ornithorhynchus anatinus	62.84	0.00e+00	1330.00
IUUC-Ocu-073938	Oryctolagus cuniculus	81.14	0.00e+00	2111.00
IUUC-Ola-086375	Oryzias latipes	64.63	0.00e+00	1167.00
IUUC-Oga-088297	Otolemur garnettii	85.34	0.00e+00	2010.00
IUUC-Ptr-091621	Pan troglodytes	86.75	0.00e+00	1705.00
IUUC-Pan-092118	Papio anubis	80.47	0.00e+00	2211.00
IUUC-Pma-094154	Petromyzon marinus	51.31	8.00e-113	401.00
IUUC-Pfo-097246	Poecilia formosa	64.19	0.00e+00	1164.00
IUUC-Pab-098551	Pongo abelii	85.22	0.00e+00	1675.00
IUUC-Pca-100158	Procavia capensis	80.30	0.00e+00	1930.00
IUUC-Pva-103160	Pteropus vampyrus	84.94	0.00e+00	1994.00
IUUC-Rno-105355	Rattus norvegicus	82.73	0.00e+00	2010.00
IUUC-Sha-107057	Sarcophilus harrisii	76.21	0.00e+00	1390.00
IUUC-Sar-113011	Sorex araneus	83.25	0.00e+00	1355.00
IUUC-Ssc-115761	Sus scrofa	83.94	0.00e+00	2226.00
IUUC-Tgu-116956	Taeniopygia guttata	61.55	0.00e+00	670.00
IUUC-Tru-118739	Takifugu rubripes	68.37	0.00e+00	1179.00
IUUC-Tsy-118827	Tarsius syrichta	74.91	0.00e+00	1111.00
IUUC-Tni-119921	Tetraodon nigroviridis	69.04	0.00e+00	1153.00
IUUC-Tbe-128017	Tupaia belangeri	84.67	0.00e+00	1628.00
IUUC-Ttr-128869	Tursiops truncatus	86.11	0.00e+00	2016.00
IUUC-Uma-129498	Ustilago maydis	29.87	5.00e-78	286.00
IUUC-Vpa-130427	Vicugna pacos	94.66	0.00e+00	919.00
IUUC-Xtr-132734	Xenopus tropicalis	73.72	0.00e+00	1251.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence