iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036243

Ensembl Protein ID

ENSFCAP00000016729.1

UniProt Accession

M3WQU7; M3WQU7_FELCA

Genbank Protein ID

ENSFCAP00000016729

Protein Name

Presenilin

Genbank Nucleotide ID

AANG02060198

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000028093.1	ENSFCAT00000025769.1	ENSFCAP00000016729.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	9.60e-09	35.1	272	310

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 272  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVS 310
           89****************************999998876 PP

Organism

Felis catus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DSRERLEHSS ERRRRGNPEL SNGRPQGNSR 60
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCCTTTT GGGCGGGGCC TAGGCCGAGC AGCTCCAGAG GCTGCGATTT CACATCGGAA 60
ACAAAACAGC GGCTGCTCGG GAAGGAGCCT CCCCTGCCAG GGGCCGGTGT CGGCGGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

fca:101087239

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	35.97	7.00e-25	109.00
IUUC-Aml-001648	Ailuropoda melanoleuca	94.79	3.00e-169	587.00
IUUC-Atr-003039	Amborella trichopoda	33.26	6.00e-39	154.00
IUUC-Apl-003727	Anas platyrhynchos	82.17	5.00e-180	623.00
IUUC-Aca-004582	Anolis carolinensis	80.68	0.00e+00	631.00
IUUC-Ath-006730	Arabidopsis thaliana	33.02	1.00e-18	87.40
IUUC-Ame-011500	Astyanax mexicanus	77.57	6.00e-150	523.00
IUUC-Bta-013026	Bos taurus	92.47	0.00e+00	725.00
IUUC-Bdi-014196	Brachypodium distachyon	32.71	3.00e-29	123.00
IUUC-Bol-015841	Brassica oleracea	36.19	2.00e-33	136.00
IUUC-Cel-018553	Caenorhabditis elegans	51.82	2.00e-94	339.00
IUUC-Cja-019994	Callithrix jacchus	96.22	0.00e+00	676.00
IUUC-Cfa-020074	Canis familiaris	97.01	0.00e+00	756.00
IUUC-Cpo-022237	Cavia porcellus	93.18	0.00e+00	689.00
IUUC-Csa-023537	Chlorocebus sabaeus	95.09	0.00e+00	758.00
IUUC-Cho-024735	Choloepus hoffmanni	81.88	0.00e+00	659.00
IUUC-Cin-025780	Ciona intestinalis	62.41	3.00e-124	438.00
IUUC-Csv-025967	Ciona savignyi	63.21	3.00e-120	425.00
IUUC-Dre-028689	Danio rerio	78.70	7.00e-146	510.00
IUUC-Dno-029758	Dasypus novemcinctus	92.54	0.00e+00	719.00
IUUC-Dor-030609	Dipodomys ordii	72.44	2.00e-168	585.00
IUUC-Dme-031929	Drosophila melanogaster	56.28	2.00e-111	395.00
IUUC-Ete-032487	Echinops telfairi	81.90	2.00e-81	296.00
IUUC-Eeu-035134	Erinaceus europaeus	93.16	3.00e-146	511.00
IUUC-Fal-036600	Ficedula albicollis	82.55	0.00e+00	627.00
IUUC-Gga-040993	Gallus gallus	83.19	0.00e+00	638.00
IUUC-Gac-042342	Gasterosteus aculeatus	69.13	2.00e-130	459.00
IUUC-Gma-043822	Glycine max	38.83	4.00e-24	105.00
IUUC-Ggo-044859	Gorilla gorilla	93.10	1.00e-161	561.00
IUUC-Hsa-046822	Homo sapiens	94.87	0.00e+00	757.00
IUUC-Hvu-047141	Hordeum vulgare	36.93	2.00e-25	110.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	94.41	5.00e-156	543.00
IUUC-Lch-049946	Latimeria chalumnae	70.85	3.00e-145	508.00
IUUC-Lpe-051132	Leersia perrieri	32.83	6.00e-29	121.00
IUUC-Loc-052469	Lepisosteus oculatus	64.48	3.00e-138	484.00
IUUC-Laf-053979	Loxodonta africana	89.19	5.00e-179	620.00
IUUC-Mcc-055682	Macaca mulatta	94.87	0.00e+00	757.00
IUUC-Meu-056004	Macropus eugenii	76.83	5.00e-155	540.00
IUUC-Mga-059466	Meleagris gallopavo	82.98	0.00e+00	636.00
IUUC-Mmr-061538	Microcebus murinus	76.71	1.00e-160	558.00
IUUC-Mdo-062122	Monodelphis domestica	88.32	0.00e+00	688.00
IUUC-Mmu-063176	Mus musculus	90.81	0.00e+00	704.00
IUUC-Mpu-065927	Mustela putorius furo	96.58	0.00e+00	744.00
IUUC-Mlu-067079	Myotis lucifugus	95.73	0.00e+00	771.00
IUUC-Nle-070180	Nomascus leucogenys	94.87	0.00e+00	757.00
IUUC-Opr-070847	Ochotona princeps	87.88	0.00e+00	664.00
IUUC-Ont-071846	Oreochromis niloticus	76.49	1.00e-146	513.00
IUUC-Oan-072783	Ornithorhynchus anatinus	84.36	1.00e-136	478.00
IUUC-Ocu-074527	Oryctolagus cuniculus	92.96	0.00e+00	738.00
IUUC-Oba-075256	Oryza barthii	34.86	3.00e-28	119.00
IUUC-Ogl-077097	Oryza glaberrima	34.10	5.00e-29	122.00
IUUC-Ogu-078570	Oryza glumaepatula	34.10	5.00e-29	122.00
IUUC-Oin-079244	Oryza indica	33.85	2.00e-28	120.00
IUUC-Olo-080484	Oryza longistaminata	37.50	5.00e-24	104.00
IUUC-Ome-081814	Oryza meridionalis	34.36	1.00e-29	124.00
IUUC-Oni-082057	Oryza nivara	33.85	2.00e-28	120.00
IUUC-Opu-084176	Oryza punctata	33.42	5.00e-29	121.00
IUUC-Oru-084618	Oryza rufipogon	34.10	6.00e-29	121.00
IUUC-Osa-085602	Oryza sativa	34.10	7.00e-29	121.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.97	5.00e-49	187.00
IUUC-Oar-090348	Ovis aries	94.02	0.00e+00	771.00
IUUC-Ptr-091060	Pan troglodytes	94.87	0.00e+00	757.00
IUUC-Pan-091855	Papio anubis	86.54	0.00e+00	660.00
IUUC-Psi-093505	Pelodiscus sinensis	83.01	0.00e+00	631.00
IUUC-Pfo-097396	Poecilia formosa	73.72	9.00e-152	530.00
IUUC-Pab-098591	Pongo abelii	93.80	0.00e+00	741.00
IUUC-Pop-099661	Populus trichocarpa	32.91	8.00e-32	131.00
IUUC-Pca-101029	Procavia capensis	87.85	0.00e+00	667.00
IUUC-Ppe-101495	Prunus persica	32.59	1.00e-37	150.00
IUUC-Pva-102244	Pteropus vampyrus	89.10	0.00e+00	689.00
IUUC-Rno-105861	Rattus norvegicus	90.64	0.00e+00	682.00
IUUC-Sha-107045	Sarcophilus harrisii	88.72	0.00e+00	686.00
IUUC-Ssl-108462	Sclerotinia sclerotiorum	23.96	4.60e-01	28.90
IUUC-Smo-109325	Selaginella moellendorffii	35.44	1.00e-37	150.00
IUUC-Sit-110624	Setaria italica	34.27	2.00e-27	116.00
IUUC-Stu-112433	Solanum tuberosum	34.93	8.00e-34	137.00
IUUC-Sar-113169	Sorex araneus	89.55	2.00e-144	505.00
IUUC-Sbi-114305	Sorghum bicolor	33.23	4.00e-25	109.00
IUUC-Ssc-115766	Sus scrofa	95.94	0.00e+00	739.00
IUUC-Tgu-116469	Taeniopygia guttata	88.50	5.00e-142	496.00
IUUC-Tru-117732	Takifugu rubripes	76.56	6.00e-146	510.00
IUUC-Tsy-119624	Tarsius syrichta	84.04	0.00e+00	652.00
IUUC-Tni-119852	Tetraodon nigroviridis	71.65	4.00e-137	481.00
IUUC-Tca-121865	Theobroma cacao	33.50	8.00e-37	147.00
IUUC-Tae-125925	Triticum aestivum	34.63	6.00e-26	112.00
IUUC-Tur-126237	Triticum urartu	36.30	5.00e-26	112.00
IUUC-Tbe-128148	Tupaia belangeri	85.94	4.00e-169	587.00
IUUC-Ttr-128793	Tursiops truncatus	95.09	0.00e+00	727.00
IUUC-Vpa-130625	Vicugna pacos	78.80	4.00e-165	574.00
IUUC-Vvi-131312	Vitis vinifera	33.42	4.00e-36	145.00
IUUC-Xtr-131790	Xenopus tropicalis	74.73	9.00e-157	546.00
IUUC-Xma-133377	Xiphophorus maculatus	75.00	9.00e-150	523.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence