iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052469

Ensembl Protein ID

ENSLOCP00000016468.1

UniProt Accession

W5N759; W5N759_LEPOC

Genbank Protein ID

ENSLOCP00000016468

Protein Name

Presenilin

Genbank Nucleotide ID

AHAT01031873

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000013357.1	ENSLOCT00000016498.1	ENSLOCP00000016468.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.40e-07	31.6	265	293

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+L+ +++
   Q: 265  VETAQERNEPIFPALIYSSTMVWLVGMAD 293
           89**********************99986 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MAENLASVLH EQLSEDFTDG HRNNVQSEGG EPRWRTEGGE AELNGQPPSS RPSQPVESEE 60
DEDEELTLKY GAKHVIMLFV PVTLCMVVVV ATIKSVSFYT QKDGQLIYTP FPEETETVGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTCTCCA ACCTAAACCG GAAATGTCGC AGCCGGATGG TTTTTGACTT CCCTGAATAG 60
TGTTAGGTGT GTGAGAAAGA AAACAGGAGA ACCGCAGCAC AAGAGGGGAA AATAAAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	66.59	2.00e-109	388.00
IUUC-Apl-003727	Anas platyrhynchos	65.03	1.00e-140	493.00
IUUC-Aca-004582	Anolis carolinensis	63.64	8.00e-138	483.00
IUUC-Ame-011500	Astyanax mexicanus	67.46	2.00e-140	492.00
IUUC-Cja-019994	Callithrix jacchus	67.74	1.00e-131	462.00
IUUC-Csa-023537	Chlorocebus sabaeus	63.36	2.00e-134	472.00
IUUC-Dno-029758	Dasypus novemcinctus	69.15	2.00e-134	472.00
IUUC-Fca-036243	Felis catus	67.15	8.00e-134	470.00
IUUC-Fal-036600	Ficedula albicollis	66.29	7.00e-145	506.00
IUUC-Gga-040993	Gallus gallus	64.96	2.00e-142	498.00
IUUC-Ggo-044859	Gorilla gorilla	76.07	3.00e-108	384.00
IUUC-Hsa-046822	Homo sapiens	63.36	2.00e-134	472.00
IUUC-Hvu-047141	Hordeum vulgare	33.74	4.00e-24	105.00
IUUC-Lch-049946	Latimeria chalumnae	77.30	2.00e-118	418.00
IUUC-Mcc-055682	Macaca mulatta	63.36	2.00e-134	472.00
IUUC-Meu-056004	Macropus eugenii	67.81	9.00e-105	373.00
IUUC-Mga-059466	Meleagris gallopavo	65.34	7.00e-142	496.00
IUUC-Mdo-062122	Monodelphis domestica	68.94	3.00e-138	485.00
IUUC-Mmu-063176	Mus musculus	62.85	6.00e-133	467.00
IUUC-Mpu-065927	Mustela putorius furo	68.49	2.00e-132	466.00
IUUC-Nle-070180	Nomascus leucogenys	63.36	2.00e-134	472.00
IUUC-Ont-071846	Oreochromis niloticus	67.47	1.00e-131	463.00
IUUC-Ocu-074527	Oryctolagus cuniculus	63.09	9.00e-134	470.00
IUUC-Obr-076302	Oryza brachyantha	30.93	2.00e-26	114.00
IUUC-Ptr-091060	Pan troglodytes	63.36	2.00e-134	472.00
IUUC-Psi-093505	Pelodiscus sinensis	65.91	2.00e-145	508.00
IUUC-Ppa-095431	Physcomitrella patens	30.33	1.00e-41	164.00
IUUC-Pfo-097396	Poecilia formosa	67.01	1.00e-144	506.00
IUUC-Pab-098591	Pongo abelii	63.64	7.00e-134	470.00
IUUC-Rno-105861	Rattus norvegicus	62.55	1.00e-135	476.00
IUUC-Sha-107045	Sarcophilus harrisii	65.80	1.00e-135	476.00
IUUC-Sbi-114305	Sorghum bicolor	33.13	4.00e-21	95.90
IUUC-Tgu-116469	Taeniopygia guttata	67.83	2.00e-109	389.00
IUUC-Tru-117732	Takifugu rubripes	67.91	5.00e-132	464.00
IUUC-Tni-119852	Tetraodon nigroviridis	63.07	3.00e-127	448.00
IUUC-Tbe-128148	Tupaia belangeri	63.22	2.00e-99	355.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence