iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037273

Ensembl Protein ID

ENSFALP00000010689.1

UniProt Accession

U3K6N5; U3K6N5_FICAL

Genbank Protein ID

ENSFALP00000010689

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGTO01001160

Gene Name

LYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000010252.1	ENSFALT00000010732.1	ENSFALP00000010689.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-16	59.6	84	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           v +ly+y++ ++++L++kkG++++vi   e++++W+++++ ++ k+G++P+n+v+k++
   Q: 84   VVALYPYDGIHEEDLSFKKGEKLKVI---EESGEWWRAKSLTTRKEGFIPSNYVAKVN 138
           889***********************...99*************************97 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MFGARCCLQT PIIGNMGCIK SKRKENLHGD GLDLKNQPVR KTERTIYVRD PTSNKQQRPA 60
NPEAQLLPGQ RFVNQDAEEH GVIVVALYPY DGIHEEDLSF KKGEKLKVIE ESGEWWRAKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGTGCG CGGGACCCGG CGCTTTCCGA GCGGTTCTCC CTCGCTTTTT CCGCCCGACC 60
TGCCCGGCAG GACTGGATGG AGTCTTAAAG GAGATAGCCG CGTTTGGGAT AAAATAATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0097028--P:dendritic cell differentiation
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0046777--P:protein autophosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050707--P:regulation of cytokine secretion
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0009725--P:response to hormone
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	89.28	0.00e+00	961.00
IUUC-Apl-004139	Anas platyrhynchos	95.36	0.00e+00	1023.00
IUUC-Aca-004333	Anolis carolinensis	89.32	0.00e+00	955.00
IUUC-Ame-011257	Astyanax mexicanus	77.86	0.00e+00	837.00
IUUC-Bta-013257	Bos taurus	88.50	0.00e+00	955.00
IUUC-Cja-018827	Callithrix jacchus	88.69	0.00e+00	955.00
IUUC-Cfa-020816	Canis familiaris	89.08	0.00e+00	959.00
IUUC-Cpo-021423	Cavia porcellus	88.89	0.00e+00	957.00
IUUC-Csa-024244	Chlorocebus sabaeus	88.50	0.00e+00	951.00
IUUC-Dre-028518	Danio rerio	78.25	0.00e+00	826.00
IUUC-Dno-029322	Dasypus novemcinctus	89.08	0.00e+00	955.00
IUUC-Dor-030706	Dipodomys ordii	79.22	0.00e+00	838.00
IUUC-Eca-034193	Equus caballus	89.67	0.00e+00	967.00
IUUC-Gmo-039677	Gadus morhua	75.11	0.00e+00	726.00
IUUC-Gga-040417	Gallus gallus	92.01	0.00e+00	978.00
IUUC-Gac-042490	Gasterosteus aculeatus	70.49	0.00e+00	776.00
IUUC-Ggo-045096	Gorilla gorilla	88.50	0.00e+00	952.00
IUUC-Hsa-046214	Homo sapiens	88.50	0.00e+00	952.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	89.47	0.00e+00	964.00
IUUC-Lch-049991	Latimeria chalumnae	81.94	0.00e+00	867.00
IUUC-Loc-052309	Lepisosteus oculatus	79.46	0.00e+00	853.00
IUUC-Laf-053568	Loxodonta africana	88.89	0.00e+00	957.00
IUUC-Mcc-054849	Macaca mulatta	88.50	0.00e+00	951.00
IUUC-Meu-056170	Macropus eugenii	74.37	0.00e+00	768.00
IUUC-Mmr-061519	Microcebus murinus	88.50	0.00e+00	956.00
IUUC-Mdo-062090	Monodelphis domestica	78.17	0.00e+00	851.00
IUUC-Mmu-063760	Mus musculus	89.08	0.00e+00	955.00
IUUC-Mpu-065677	Mustela putorius furo	89.47	0.00e+00	966.00
IUUC-Mlu-067386	Myotis lucifugus	89.28	0.00e+00	963.00
IUUC-Nle-069742	Nomascus leucogenys	88.50	0.00e+00	952.00
IUUC-Ont-071537	Oreochromis niloticus	73.11	0.00e+00	790.00
IUUC-Oan-073193	Ornithorhynchus anatinus	88.13	0.00e+00	952.00
IUUC-Ocu-074501	Oryctolagus cuniculus	89.28	0.00e+00	962.00
IUUC-Ola-086726	Oryzias latipes	70.43	0.00e+00	774.00
IUUC-Oga-088069	Otolemur garnettii	88.35	0.00e+00	955.00
IUUC-Oar-090091	Ovis aries	87.43	0.00e+00	959.00
IUUC-Ptr-091409	Pan troglodytes	88.50	0.00e+00	952.00
IUUC-Pan-092268	Papio anubis	88.54	0.00e+00	956.00
IUUC-Psi-093685	Pelodiscus sinensis	91.89	0.00e+00	983.00
IUUC-Pfo-096217	Poecilia formosa	73.01	0.00e+00	798.00
IUUC-Pab-098601	Pongo abelii	88.50	0.00e+00	952.00
IUUC-Pva-102160	Pteropus vampyrus	77.69	0.00e+00	825.00
IUUC-Rno-105557	Rattus norvegicus	89.28	0.00e+00	962.00
IUUC-Sha-106643	Sarcophilus harrisii	88.13	0.00e+00	948.00
IUUC-Sar-113555	Sorex araneus	87.21	3.00e-160	557.00
IUUC-Ssc-116317	Sus scrofa	82.68	0.00e+00	881.00
IUUC-Tgu-116865	Taeniopygia guttata	99.22	0.00e+00	1061.00
IUUC-Tru-118284	Takifugu rubripes	71.60	0.00e+00	786.00
IUUC-Tsy-119440	Tarsius syrichta	84.42	0.00e+00	912.00
IUUC-Tni-120005	Tetraodon nigroviridis	70.27	0.00e+00	772.00
IUUC-Ttr-128481	Tursiops truncatus	75.88	0.00e+00	781.00
IUUC-Xtr-131907	Xenopus tropicalis	76.45	0.00e+00	796.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence