iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072573

Ensembl Protein ID

ENSONIP00000023927.1

UniProt Accession

I3KS31; I3KS31_ORENI

Genbank Protein ID

ENSONIP00000023927

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01006691

Gene Name

usp4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000019003.1	ENSONIT00000023948.1	ENSONIP00000023927.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.40e-114	381.1	316	969
ULD/UDP/UBQ/UBQ_Other	1.00e-12	48.2	166	238

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+LQcLsn ++l+e++l+ +++ ++n+enp ++ ge+++++++l++++w s++++v+pr+++++++++a++fsgy+
   Q: 316  CGLSNLGNTCFMNSALQCLSNASPLTEYFLTdQYEAEINRENPLGMRGEIAEAYADLVKQMWLSRSSYVAPRTFKTQVGRFAPQFSGYQ 404
           7*****************************999******************************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+  +++++   ++de     a+ ++  +n+s+i+d+F+g +ks+++c+ec +vs++++pf++l
   Q: 405  QQDSQELLAFLLDGLHEDLNRVKKKPYLALRDAE--GRPDEivakeAWTNHRLRNDSIIVDIFHGLFKSTLVCPECSKVSVTFDPFCYL 491
           ***************************9998887..6666667777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 492  TLPLPLKKDRTMEvflvrsdpqsrptqyrvvvpklgtitdlcsalsklcgippenmvvadvynhrfhklyrrddglnqimekddifvye 580
           ********99888**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 581  vqeensermnlpvyfrerhskhagsststmlfgqpllitvprhnliadvlydkilerigryvkhsqspstesrasasatlsscsqapec 669
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 670  stsssliaslggcgsplsdgascsasssngsnhsgtcnetnglydgeeeamdhqvspepengqseeeeeasdlqngskgdttklftfsi 758
           ***************************************************************************************** PP
   S: 186  ................................................................slqdcLesftkeeelegenkyycek 210
                                                                            l++c+e ft+ e+l +++ +yc++
   Q: 759  vnsygtanisplpcdgnvlklnphstvaidwdteskklyydepeaeayekhesmlqpqrkkttvALRECIELFTTMETLGEHDPWYCPT 847
           ***************************************************************************************** PP
   S: 211  ckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvay 298
           ckk+q+a+kk++l++lP++L++hLkRfs+++  + r k+++ v+fp++ L++s+f+++p+ +   +++Y+Liav +H+G++++GHY+ay
   Q: 848  CKKHQQATKKFDLWSLPRILVVHLKRFSYNR--CWRDKLDTVVDFPIRdLNMSEFVCDPKAG---PYIYDLIAVSNHYGGMGGGHYTAY 931
           ***************************9966..6778*********************9987...8*********************** PP
   S: 299  vkne.kgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
            kn+ +gkW++fdDs+V++ +e+++++   + aYvlfY+rr
   Q: 932  GKNKvDGKWYYFDDSSVSSATEDQIVT---KAAYVLFYQRR 969
           ***62666*******************...*********96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 11   s.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
             + t++++++dt+ ++ ++++++++ip +e+ rL++k      + L ++d t++d gl++g+++++++k+++
   Q: 166  DnVVTRHFSKADTIDTIEKEMRTLFNIPsEEETRLWNKymsntYEQLnKPDSTVQDAGLFQGQVLVIERKNED 238
           3478999*********************888*****999987744457*******************999876 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MMAEGGGPES GNAADSDSEP VAAQIPTPST ESQKQTIGSL LKTSLKKGDE WYLIDSRWFK 60
QWKKYVGFDS WDMYNVGERS LYPGPIDNSG LFSDQETQAL KEHLIDELDY VLVPTEAWNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTATTTAA CTGCCTGGAC GTCTGTTTAA CGAGCTCTAA AAACCTATAA TGTAAGTGAA 60
AATTATCATC AGATTAGCGA ACACAGAGCT GAAGCACAGG AACTGCAAGA TCCTTTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0034122--P:negative regulation of toll-like receptor signaling pathway
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	40.48	1.00e-120	427.00
IUUC-Aml-001597	Ailuropoda melanoleuca	66.98	0.00e+00	1253.00
IUUC-Apl-004068	Anas platyrhynchos	61.63	0.00e+00	1098.00
IUUC-Aly-006315	Arabidopsis lyrata	37.90	1.00e-96	348.00
IUUC-Ath-007343	Arabidopsis thaliana	38.25	4.00e-108	386.00
IUUC-Ago-007911	Ashbya gossypii	39.32	3.00e-65	244.00
IUUC-Acl-008284	Aspergillus clavatus	37.24	1.00e-56	215.00
IUUC-Afl-008507	Aspergillus flavus	35.70	1.00e-57	219.00
IUUC-Afu-008878	Aspergillus fumigatus	29.59	2.00e-62	235.00
IUUC-Ani-009479	Aspergillus nidulans	36.96	4.00e-54	207.00
IUUC-Ang-009562	Aspergillus niger	34.93	2.00e-58	221.00
IUUC-Aor-009949	Aspergillus oryzae	35.70	5.00e-57	216.00
IUUC-Ate-010323	Aspergillus terreus	38.99	2.00e-59	225.00
IUUC-Ame-011064	Astyanax mexicanus	79.31	0.00e+00	1103.00
IUUC-Bgr-012277	Blumeria graminis	44.80	4.00e-64	241.00
IUUC-Bta-012929	Bos taurus	65.70	0.00e+00	1278.00
IUUC-Bci-013993	Botrytis cinerea	43.57	5.00e-65	243.00
IUUC-Bdi-015062	Brachypodium distachyon	40.63	4.00e-125	442.00
IUUC-Cfa-020599	Canis familiaris	66.03	0.00e+00	1262.00
IUUC-Cpo-022144	Cavia porcellus	65.98	0.00e+00	1230.00
IUUC-Csa-023770	Chlorocebus sabaeus	66.92	0.00e+00	1172.00
IUUC-Cho-024595	Choloepus hoffmanni	58.71	0.00e+00	775.00
IUUC-Csv-026109	Ciona savignyi	46.41	8.00e-150	524.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	35.71	3.00e-65	244.00
IUUC-Dre-027869	Danio rerio	81.58	0.00e+00	1566.00
IUUC-Dno-029316	Dasypus novemcinctus	66.06	0.00e+00	1276.00
IUUC-Ete-032970	Echinops telfairi	59.97	0.00e+00	767.00
IUUC-Eca-034012	Equus caballus	64.42	0.00e+00	1248.00
IUUC-Fal-037634	Ficedula albicollis	65.10	0.00e+00	1196.00
IUUC-Gmo-038866	Gadus morhua	85.07	0.00e+00	1041.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	1.00e-62	236.00
IUUC-Gga-040729	Gallus gallus	59.45	0.00e+00	1135.00
IUUC-Gac-042631	Gasterosteus aculeatus	91.76	0.00e+00	1201.00
IUUC-Ggo-045337	Gorilla gorilla	65.04	0.00e+00	1124.00
IUUC-Hsa-045669	Homo sapiens	66.30	0.00e+00	1253.00
IUUC-Hvu-047108	Hordeum vulgare	39.82	1.00e-121	430.00
IUUC-Lch-050533	Latimeria chalumnae	67.63	0.00e+00	1179.00
IUUC-Lpe-051424	Leersia perrieri	36.12	6.00e-148	518.00
IUUC-Loc-051800	Lepisosteus oculatus	78.14	0.00e+00	1582.00
IUUC-Mcc-055556	Macaca mulatta	63.23	0.00e+00	1176.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	1.00e-62	236.00
IUUC-Mla-058848	Melampsora laricipopulina	32.74	9.00e-80	292.00
IUUC-Mga-059300	Meleagris gallopavo	60.50	0.00e+00	1097.00
IUUC-Mvi-060324	Microbotryum violaceum	30.73	2.00e-81	298.00
IUUC-Mmu-063960	Mus musculus	66.88	0.00e+00	1244.00
IUUC-Mpu-066920	Mustela putorius furo	66.43	0.00e+00	1266.00
IUUC-Nfi-068330	Neosartorya fischeri	29.64	4.00e-63	237.00
IUUC-Ncr-068879	Neurospora crassa	45.71	3.00e-63	238.00
IUUC-Nle-070010	Nomascus leucogenys	66.53	0.00e+00	1252.00
IUUC-Oan-073363	Ornithorhynchus anatinus	64.53	0.00e+00	1179.00
IUUC-Olo-080315	Oryza longistaminata	35.58	1.00e-141	497.00
IUUC-Ome-081271	Oryza meridionalis	35.08	5.00e-146	511.00
IUUC-Opu-083691	Oryza punctata	34.29	2.00e-141	497.00
IUUC-Osa-086139	Oryza sativa	35.08	1.00e-143	504.00
IUUC-Ola-086553	Oryzias latipes	85.99	0.00e+00	1661.00
IUUC-Oar-090439	Ovis aries	66.91	0.00e+00	1269.00
IUUC-Ptr-090801	Pan troglodytes	65.76	0.00e+00	1255.00
IUUC-Pan-092717	Papio anubis	61.96	0.00e+00	1132.00
IUUC-Psi-093942	Pelodiscus sinensis	65.76	0.00e+00	1178.00
IUUC-Pfo-097060	Poecilia formosa	90.27	0.00e+00	1734.00
IUUC-Pca-100161	Procavia capensis	64.49	0.00e+00	837.00
IUUC-Ppe-102062	Prunus persica	40.92	1.00e-118	420.00
IUUC-Pgr-103546	Puccinia graminis	29.40	7.00e-71	263.00
IUUC-Rno-106081	Rattus norvegicus	66.09	0.00e+00	1261.00
IUUC-Sha-106937	Sarcophilus harrisii	68.19	0.00e+00	1262.00
IUUC-Sit-109948	Setaria italica	36.16	7.00e-141	494.00
IUUC-Ssc-115637	Sus scrofa	69.48	0.00e+00	912.00
IUUC-Tgu-117267	Taeniopygia guttata	63.92	0.00e+00	1179.00
IUUC-Tru-118634	Takifugu rubripes	90.16	0.00e+00	1108.00
IUUC-Tni-120107	Tetraodon nigroviridis	83.60	0.00e+00	1096.00
IUUC-Tca-121001	Theobroma cacao	36.13	2.00e-155	543.00
IUUC-Tre-121888	Trichoderma reesei	41.46	1.00e-65	246.00
IUUC-Tae-123874	Triticum aestivum	40.96	2.00e-126	446.00
IUUC-Tme-127062	Tuber melanosporum	31.64	2.00e-82	301.00
IUUC-Ttr-128778	Tursiops truncatus	66.21	0.00e+00	1222.00
IUUC-Xtr-132305	Xenopus tropicalis	65.11	0.00e+00	1268.00
IUUC-Xma-133176	Xiphophorus maculatus	90.86	0.00e+00	1548.00
IUUC-Yli-134392	Yarrowia lipolytica	44.60	1.00e-64	242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence