iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052090

Ensembl Protein ID

ENSLOCP00000018656.1

UniProt Accession

W5NDE7; W5NDE7_LEPOC

Genbank Protein ID

ENSLOCP00000018656

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AHAT01025561

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000015153.1	ENSLOCT00000018688.1	ENSLOCP00000018656.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-57	189.0	1013	1049
UBD/Beta-Prp	2.90e-97	325.6	614	825

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gHt +v  ++f  d ++l+++s D ti+vWD+r+  +
   Q: 1013 GHTKPVQHCEFtADgRTLITCSEDTTIRVWDWRSSEC 1049
           8***********55599***************99877 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           + hk+ i+  +fs+d++ +a+ ++d+t++v++  tg ++  +  he+ev ++ fspd+k+++t+s+Dr ik+w+ + gk ++++++h++
   Q: 614  QPHKGSIYYACFSRDGEKIASCGADRTVQVFRSVTGEKVLDIVAHEEEVLCCAFSPDDKLIATCSTDRKIKIWNAERGKLIRIYEEHSE 702
           679999999******************************************************************************** PP
   S: 96   svlslsfsp..sgdklvsGshdrtirv....wdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl... 175
           +v  ++f    ++  l++Gs+d  +++    w++++ +c + tl gh+++vn+ +++pd+  l+s+s D+t++lW++++g+  +     
   Q: 703  QVNHCQFTNssYRILLATGSNDCFLKLilklWNINKPTCQN-TLFGHTEAVNHCCFSPDDAHLASCSSDGTLKLWQVSSGNEWKSIdvf 790
           *********54456789******99999999**********.***********************************777655554444 PP
   S: 176  .........tgghtds.vyslsfdsngkelvsgsld 201
                    ++   d  v++ +++++g ++++++++
   Q: 791  syfpsspdsRE-EGDViVKCGAWSPDGSRIIAAAKN 825
           77787666433.333303444488888888887776 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

EVMEEQARSR LLCSRSKLED DIKALYLMDH MVSDEVLSAD EEETVKAKAT RREQAAALID 60
LILRKDNHAY VSLYNALIRE SYSDLASLLQ KDLPLISPRA DKSFPDGESP GVQAVLREGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAAACTGG TCTGACGTAA GGGAGGCGTT CTTTCTTGAA ACATGTAAAC AGAAACTGAA 60
CAGGGAGGAG CTGGAAATAG TTTCTGAAAC CCTGAATTGC ATCGGACATG AGACTATAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	59.49	0.00e+00	1548.00
IUUC-Apl-004201	Anas platyrhynchos	59.46	0.00e+00	1566.00
IUUC-Aca-004638	Anolis carolinensis	57.70	0.00e+00	1568.00
IUUC-Ani-009285	Aspergillus nidulans	28.21	3.00e-73	270.00
IUUC-Ate-010309	Aspergillus terreus	29.08	6.00e-73	269.00
IUUC-Ame-011062	Astyanax mexicanus	66.77	0.00e+00	1707.00
IUUC-Bta-012865	Bos taurus	59.56	0.00e+00	1578.00
IUUC-Cja-018815	Callithrix jacchus	52.37	0.00e+00	1340.00
IUUC-Cfa-020222	Canis familiaris	56.44	0.00e+00	1439.00
IUUC-Cpo-021524	Cavia porcellus	59.00	0.00e+00	1561.00
IUUC-Cre-022958	Chlamydomonas reinhardtii	22.16	6.00e-35	143.00
IUUC-Csa-023861	Chlorocebus sabaeus	59.24	0.00e+00	1551.00
IUUC-Cho-024484	Choloepus hoffmanni	49.61	0.00e+00	758.00
IUUC-Dre-028006	Danio rerio	64.95	0.00e+00	1592.00
IUUC-Dno-029591	Dasypus novemcinctus	59.83	0.00e+00	1577.00
IUUC-Dor-030237	Dipodomys ordii	49.37	0.00e+00	694.00
IUUC-Ete-032620	Echinops telfairi	56.25	0.00e+00	741.00
IUUC-Eca-033569	Equus caballus	59.65	0.00e+00	1558.00
IUUC-Eeu-035354	Erinaceus europaeus	44.76	5.00e-114	405.00
IUUC-Fca-036337	Felis catus	58.87	0.00e+00	1557.00
IUUC-Fal-037077	Ficedula albicollis	59.59	0.00e+00	1570.00
IUUC-Gmo-039687	Gadus morhua	60.61	0.00e+00	1157.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.92	3.00e-40	161.00
IUUC-Gga-040299	Gallus gallus	58.11	0.00e+00	1569.00
IUUC-Gac-041762	Gasterosteus aculeatus	61.67	0.00e+00	1571.00
IUUC-Ggo-045563	Gorilla gorilla	59.79	0.00e+00	1566.00
IUUC-Hsa-046771	Homo sapiens	59.56	0.00e+00	1560.00
IUUC-Lch-050200	Latimeria chalumnae	63.75	0.00e+00	1617.00
IUUC-Laf-053861	Loxodonta africana	59.86	0.00e+00	1572.00
IUUC-Mcc-055543	Macaca mulatta	59.56	0.00e+00	1560.00
IUUC-Meu-056688	Macropus eugenii	60.76	0.00e+00	1559.00
IUUC-Mga-059243	Meleagris gallopavo	58.41	0.00e+00	1570.00
IUUC-Mmr-061134	Microcebus murinus	55.67	0.00e+00	1339.00
IUUC-Mdo-062913	Monodelphis domestica	60.11	0.00e+00	1558.00
IUUC-Mmu-063811	Mus musculus	60.35	0.00e+00	1574.00
IUUC-Mpu-066780	Mustela putorius furo	59.27	0.00e+00	1536.00
IUUC-Mlu-067276	Myotis lucifugus	59.75	0.00e+00	1573.00
IUUC-Nle-069129	Nomascus leucogenys	59.48	0.00e+00	1553.00
IUUC-Opr-071007	Ochotona princeps	46.01	0.00e+00	748.00
IUUC-Ont-071348	Oreochromis niloticus	66.01	0.00e+00	1727.00
IUUC-Oan-072717	Ornithorhynchus anatinus	61.19	0.00e+00	1629.00
IUUC-Ocu-074286	Oryctolagus cuniculus	59.53	0.00e+00	1338.00
IUUC-Ola-086895	Oryzias latipes	59.75	0.00e+00	1461.00
IUUC-Oga-088678	Otolemur garnettii	59.73	0.00e+00	1558.00
IUUC-Oar-089359	Ovis aries	60.11	0.00e+00	1582.00
IUUC-Ptr-091062	Pan troglodytes	59.71	0.00e+00	1563.00
IUUC-Pan-092528	Papio anubis	61.39	0.00e+00	950.00
IUUC-Psi-093430	Pelodiscus sinensis	60.43	0.00e+00	1594.00
IUUC-Pma-094690	Petromyzon marinus	42.23	5.00e-167	581.00
IUUC-Pfo-097204	Poecilia formosa	64.30	0.00e+00	1659.00
IUUC-Pab-097690	Pongo abelii	59.64	0.00e+00	1566.00
IUUC-Pca-100778	Procavia capensis	47.34	0.00e+00	783.00
IUUC-Pva-102870	Pteropus vampyrus	59.51	0.00e+00	1444.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	29.31	3.00e-65	244.00
IUUC-Rno-104889	Rattus norvegicus	59.87	0.00e+00	1546.00
IUUC-Sha-107465	Sarcophilus harrisii	59.22	0.00e+00	1561.00
IUUC-Sar-113268	Sorex araneus	58.03	4.00e-128	452.00
IUUC-Ssc-115654	Sus scrofa	59.32	0.00e+00	1578.00
IUUC-Tgu-117302	Taeniopygia guttata	59.32	0.00e+00	1575.00
IUUC-Tru-118363	Takifugu rubripes	64.98	0.00e+00	1690.00
IUUC-Tsy-119007	Tarsius syrichta	57.41	0.00e+00	1484.00
IUUC-Tni-120910	Tetraodon nigroviridis	64.41	0.00e+00	1635.00
IUUC-Tbe-127413	Tupaia belangeri	50.05	0.00e+00	920.00
IUUC-Ttr-129213	Tursiops truncatus	55.19	0.00e+00	1418.00
IUUC-Vpa-130146	Vicugna pacos	55.10	0.00e+00	1072.00
IUUC-Xtr-132559	Xenopus tropicalis	55.44	0.00e+00	1428.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence