iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093430

Ensembl Protein ID

ENSPSIP00000013575.1

UniProt Accession

K7FZW5; K7FZW5_PELSI

Genbank Protein ID

ENSPSIP00000013575

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AGCU01052913

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000011998.1	ENSPSIT00000013639.1	ENSPSIP00000013575.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-57	186.4	1130	1167
UBD/Beta-Prp	2.20e-88	296.3	961	1242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c+ f  +d++l++G d+g i++WD++ g ll
   Q: 1130 GHKGCVRCCTFsfDDKFLATGDDNGEIRIWDVSGGELL 1167
           8***********777****************9877766 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           l ++++s+i+c + s+d ++ a g ++gt+kv ++++  +++s  ghe+ v+ ++f +dg++l+++s+D ti+vw+ ++ +++  lk
   Q: 961  LTEAQESPICCCCLSEDLQYAAFGEENGTVKVLELSNRRVFKSSTGHEKSVQHCQFTSDGQTLISSSDDSTIQVWNWQSEEYI-FLK 1046
           568999************************************************************************99876.69* PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           gh++ v   ++ + +++l+s s d t++vw++ +g+     l  h+++v + +v+ d+  + s s+D+t ++W+ ++ ++l++l g 
   Q: 1047 GHKEAVKNFRLLE-NSRLLSWSFDGTVKVWNICNGKIED-DLVCHEDAVLSCAVSLDATKFSSTSADKTAKIWSFESSSVLHELIG- 1130
           *************.99**********************9.66666666666667777999*************************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
           h++ v++ +f+ + k+l++g+++g +++wd++ ge ++ +   t          +v+++ fsp+++ lvs++  g +  W++ ++++
   Q: 1131 HKGCVRCCTFSFDDKFLATGDDNGEIRIWDVSGGELLHLYSPVTvdggesthgGWVTDLCFSPDSNMLVSCG--GYLTWWNIMTKEP 1215
           ********************************999866555555555556666*******************..************* PP
   S: 257  lktlqlhnssvisvavlsfgdnvlvlgs 284
           l+t+    +++ s++v s++ +++v+ +
   Q: 1216 LQTFYTNGTNLKSICV-SPSFKIYVTID 1242
           ****987777777766.77777777765 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

KMDVKSRNHL LLNHEALERD IKTSYIMDHM IADEVLTLQE EEKVKAQTTQ RERAAMLIKI 60
ILAKDNYSYI SFYNALLHEG YKDLAALLQD GIPILSCKGN KSMDGGTSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCGGACCC TCTGCGTGGC CGGAGCTTCT GCCGTCGCCC AACCCCCCGG GAGTGCAATG 60
AGGTAGGGGT CTCGCTGGCA CGTGCTTGCT GAGGCTGCGG CGTGGCTCAG CTATACCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	74.56	0.00e+00	1939.00
IUUC-Apl-004201	Anas platyrhynchos	79.31	0.00e+00	2038.00
IUUC-Aca-004638	Anolis carolinensis	74.42	0.00e+00	1972.00
IUUC-Afu-008928	Aspergillus fumigatus	28.36	6.00e-61	229.00
IUUC-Ani-009285	Aspergillus nidulans	25.53	3.00e-65	244.00
IUUC-Ang-009637	Aspergillus niger	26.91	1.00e-29	125.00
IUUC-Ate-010309	Aspergillus terreus	26.07	1.00e-68	254.00
IUUC-Ame-011062	Astyanax mexicanus	56.49	0.00e+00	1415.00
IUUC-Bta-012865	Bos taurus	75.14	0.00e+00	1989.00
IUUC-Cja-018815	Callithrix jacchus	67.57	0.00e+00	1726.00
IUUC-Cfa-020222	Canis familiaris	71.30	0.00e+00	1824.00
IUUC-Cpo-021524	Cavia porcellus	73.05	0.00e+00	1924.00
IUUC-Csa-023861	Chlorocebus sabaeus	74.08	0.00e+00	1940.00
IUUC-Cho-024484	Choloepus hoffmanni	63.54	0.00e+00	993.00
IUUC-Dre-028006	Danio rerio	54.34	0.00e+00	1302.00
IUUC-Dno-029591	Dasypus novemcinctus	75.26	0.00e+00	1994.00
IUUC-Dor-030237	Dipodomys ordii	60.85	0.00e+00	881.00
IUUC-Ete-032620	Echinops telfairi	70.16	0.00e+00	909.00
IUUC-Eca-033569	Equus caballus	74.42	0.00e+00	1942.00
IUUC-Eeu-035354	Erinaceus europaeus	52.89	5.00e-142	498.00
IUUC-Fca-036337	Felis catus	74.66	0.00e+00	1974.00
IUUC-Fal-037077	Ficedula albicollis	78.74	0.00e+00	2016.00
IUUC-Gmo-039687	Gadus morhua	51.41	0.00e+00	955.00
IUUC-Ggr-039828	Gaeumannomyces graminis	21.98	1.00e-42	169.00
IUUC-Gga-040299	Gallus gallus	77.49	0.00e+00	2025.00
IUUC-Gac-041762	Gasterosteus aculeatus	53.40	0.00e+00	1302.00
IUUC-Ggo-045563	Gorilla gorilla	73.94	0.00e+00	1939.00
IUUC-Hsa-046771	Homo sapiens	73.76	0.00e+00	1934.00
IUUC-Lch-050200	Latimeria chalumnae	66.72	0.00e+00	1692.00
IUUC-Loc-052090	Lepisosteus oculatus	60.27	0.00e+00	1554.00
IUUC-Laf-053861	Loxodonta africana	74.18	0.00e+00	1948.00
IUUC-Mcc-055543	Macaca mulatta	74.08	0.00e+00	1941.00
IUUC-Meu-056688	Macropus eugenii	73.50	0.00e+00	1890.00
IUUC-Mga-059243	Meleagris gallopavo	77.59	0.00e+00	2039.00
IUUC-Mmr-061134	Microcebus murinus	70.25	0.00e+00	1661.00
IUUC-Mdo-062913	Monodelphis domestica	72.23	0.00e+00	1884.00
IUUC-Mmu-063811	Mus musculus	72.49	0.00e+00	1926.00
IUUC-Mpu-066780	Mustela putorius furo	74.74	0.00e+00	1934.00
IUUC-Mlu-067276	Myotis lucifugus	74.84	0.00e+00	1971.00
IUUC-Nfi-068459	Neosartorya fischeri	25.18	7.00e-59	222.00
IUUC-Nle-069129	Nomascus leucogenys	73.52	0.00e+00	1930.00
IUUC-Opr-071007	Ochotona princeps	54.84	0.00e+00	904.00
IUUC-Ont-071348	Oreochromis niloticus	56.69	0.00e+00	1436.00
IUUC-Oan-072717	Ornithorhynchus anatinus	76.87	0.00e+00	2019.00
IUUC-Ocu-074286	Oryctolagus cuniculus	74.29	0.00e+00	1662.00
IUUC-Ola-086895	Oryzias latipes	51.52	0.00e+00	1224.00
IUUC-Oga-088678	Otolemur garnettii	73.37	0.00e+00	1929.00
IUUC-Oar-089359	Ovis aries	75.06	0.00e+00	1977.00
IUUC-Ptr-091062	Pan troglodytes	73.68	0.00e+00	1932.00
IUUC-Pan-092528	Papio anubis	77.91	0.00e+00	1177.00
IUUC-Pma-094690	Petromyzon marinus	37.39	8.00e-146	510.00
IUUC-Pfo-097204	Poecilia formosa	55.56	0.00e+00	1399.00
IUUC-Pab-097690	Pongo abelii	74.16	0.00e+00	1946.00
IUUC-Pca-100778	Procavia capensis	58.93	0.00e+00	986.00
IUUC-Pva-102870	Pteropus vampyrus	72.12	0.00e+00	1752.00
IUUC-Rno-104889	Rattus norvegicus	72.73	0.00e+00	1907.00
IUUC-Sha-107465	Sarcophilus harrisii	73.43	0.00e+00	1943.00
IUUC-Smo-108976	Selaginella moellendorffii	28.19	1.00e-32	133.00
IUUC-Sar-113268	Sorex araneus	71.51	8.00e-154	538.00
IUUC-Ssc-115654	Sus scrofa	74.24	0.00e+00	1966.00
IUUC-Tgu-117302	Taeniopygia guttata	79.38	0.00e+00	2041.00
IUUC-Tru-118363	Takifugu rubripes	56.05	0.00e+00	1404.00
IUUC-Tsy-119007	Tarsius syrichta	72.71	0.00e+00	1887.00
IUUC-Tni-120910	Tetraodon nigroviridis	54.31	0.00e+00	1363.00
IUUC-Tbe-127413	Tupaia belangeri	64.47	0.00e+00	1196.00
IUUC-Ttr-129213	Tursiops truncatus	68.72	0.00e+00	1775.00
IUUC-Vpa-130146	Vicugna pacos	69.45	0.00e+00	1346.00
IUUC-Xtr-132559	Xenopus tropicalis	61.12	0.00e+00	1573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence