iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118363

Ensembl Protein ID

ENSTRUP00000033561.1

UniProt Accession

H2U9E5; H2U9E5_TAKRU

Protein Name

Apoptotic protease-activating factor 1

Gene Name

apaf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000013192.1	ENSTRUT00000033687.1	ENSTRUP00000033561.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.00e-57	187.7	658	695
UBD/Beta-Prp	1.80e-96	324.1	961	1225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H d+v c+af +d +ll+++s D ++kvW++ + +ll+
   Q: 658  HDDEVLCCAFsPDdRLLATCSSDRKVKVWNVEQARLLR 695
           9**********777*****************9988775 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           ++++s+i+c +  ++ + ++ g +dgt++v ++ tgk+l++l gh+++v +++fs+dg++l+t+seD ti+vw   +g+c  +l+gh
   Q: 961  EEKSSRIRCTCLCRQPPAVVIGQEDGTVQVLELPTGKVLATLLGHTKTVFCCQFSQDGQTLITSSEDTTIRVWRWLSGECK-VLQGH 1046
           66788999999999*****************************************************************96.699** PP
   S: 94   edsvls...lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
            ++v++   ls+sps+ +l+s s d t+++wd+e+g++l+   + h+g++ + +v+pdg+l+++ s+Drt +lW  ++ ++++ l+g
   Q: 1047 REQVRCftlLSSSPSKMRLLSWSFDGTVKMWDTESGEKLQ-DVEAHQGAILSCHVSPDGCLFATTSADRTAKLWHCESWQCVHALKG 1132
           ******88889999**************************.6778999999999********************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDgsiriWdlrsgd 255
            h++ v+s  f+ +++++++g+++g ++lw+++ g+ ++++   +          +v++++fs++d +lvs++  g i+ Wd+ +g+
   Q: 1133 -HQECVRSCRFSWDSRRVATGDDNGEIRLWSVSDGSLLKICSRDSkdgmdslhgGWVTDLHFSRDDSLLVSTG--GYIKWWDVAQGE 1216
           .********************************999988888877788888888*******************..************ PP
   S: 256  llktlqlhn 264
            l+t+  + 
   Q: 1217 ALQTFHPTG 1225
           ****98665 PP

Organism

Takifugu rubripes

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

LEEGARSSLL RFRHQLEQDI KPSYLMDHMI SDGVLSVDEE EKIRTLATRK DQAVALLDLL 60
LRKDNRTYIS FYNSLVKETY DDLATLLHEY LPRLSPGATK NASDGCTPYV QTVLSEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGAGGAAG GTGCGAGGAG CTCTCTGCTG CGCTTTCGAC ACCAATTAGA GCAGGACATC 60
AAGCCATCCT ACCTGATGGA TCACATGATC AGTGACGGTG TGCTTAGCGT AGATGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0097190--P:apoptotic signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	53.69	0.00e+00	1376.00
IUUC-Apl-004201	Anas platyrhynchos	54.58	0.00e+00	1391.00
IUUC-Aca-004638	Anolis carolinensis	53.78	0.00e+00	1394.00
IUUC-Ani-009285	Aspergillus nidulans	27.30	4.00e-65	243.00
IUUC-Ame-011062	Astyanax mexicanus	70.34	0.00e+00	1797.00
IUUC-Bta-012865	Bos taurus	54.29	0.00e+00	1402.00
IUUC-Cja-018815	Callithrix jacchus	50.47	0.00e+00	1234.00
IUUC-Cfa-020222	Canis familiaris	51.06	0.00e+00	1281.00
IUUC-Cpo-021524	Cavia porcellus	54.05	0.00e+00	1394.00
IUUC-Csa-023861	Chlorocebus sabaeus	54.29	0.00e+00	1399.00
IUUC-Cho-024484	Choloepus hoffmanni	45.60	0.00e+00	671.00
IUUC-Dre-028006	Danio rerio	67.31	0.00e+00	1649.00
IUUC-Dno-029591	Dasypus novemcinctus	55.09	0.00e+00	1423.00
IUUC-Dor-030237	Dipodomys ordii	43.00	1.00e-163	571.00
IUUC-Ete-032620	Echinops telfairi	49.44	9.00e-177	614.00
IUUC-Eca-033569	Equus caballus	54.13	0.00e+00	1388.00
IUUC-Eeu-035354	Erinaceus europaeus	39.63	5.00e-94	339.00
IUUC-Fca-036337	Felis catus	53.77	0.00e+00	1394.00
IUUC-Fal-037077	Ficedula albicollis	54.26	0.00e+00	1373.00
IUUC-Gmo-039687	Gadus morhua	64.29	0.00e+00	1223.00
IUUC-Gga-040299	Gallus gallus	53.17	0.00e+00	1380.00
IUUC-Gac-041762	Gasterosteus aculeatus	77.78	0.00e+00	1967.00
IUUC-Ggo-045563	Gorilla gorilla	54.53	0.00e+00	1407.00
IUUC-Hsa-046771	Homo sapiens	54.69	0.00e+00	1410.00
IUUC-Lch-050200	Latimeria chalumnae	57.87	0.00e+00	1446.00
IUUC-Loc-052090	Lepisosteus oculatus	64.98	0.00e+00	1651.00
IUUC-Laf-053861	Loxodonta africana	54.49	0.00e+00	1402.00
IUUC-Mcc-055543	Macaca mulatta	54.45	0.00e+00	1404.00
IUUC-Meu-056688	Macropus eugenii	56.20	0.00e+00	1396.00
IUUC-Mga-059243	Meleagris gallopavo	53.34	0.00e+00	1382.00
IUUC-Mmr-061134	Microcebus murinus	51.18	0.00e+00	1176.00
IUUC-Mdo-062913	Monodelphis domestica	55.41	0.00e+00	1389.00
IUUC-Mmu-063811	Mus musculus	54.85	0.00e+00	1412.00
IUUC-Mpu-066780	Mustela putorius furo	53.61	0.00e+00	1372.00
IUUC-Mlu-067276	Myotis lucifugus	54.25	0.00e+00	1391.00
IUUC-Nle-069129	Nomascus leucogenys	54.29	0.00e+00	1401.00
IUUC-Opr-071007	Ochotona princeps	40.74	2.00e-177	616.00
IUUC-Ont-071348	Oreochromis niloticus	81.69	0.00e+00	2129.00
IUUC-Oan-072717	Ornithorhynchus anatinus	55.45	0.00e+00	1437.00
IUUC-Ocu-074286	Oryctolagus cuniculus	54.05	0.00e+00	1172.00
IUUC-Ola-086895	Oryzias latipes	69.14	0.00e+00	1711.00
IUUC-Oga-088678	Otolemur garnettii	54.53	0.00e+00	1402.00
IUUC-Oar-089359	Ovis aries	54.61	0.00e+00	1402.00
IUUC-Ptr-091062	Pan troglodytes	54.69	0.00e+00	1411.00
IUUC-Pan-092528	Papio anubis	57.92	0.00e+00	870.00
IUUC-Psi-093430	Pelodiscus sinensis	56.05	0.00e+00	1408.00
IUUC-Pma-094690	Petromyzon marinus	39.92	9.00e-150	524.00
IUUC-Pfo-097204	Poecilia formosa	77.88	0.00e+00	2025.00
IUUC-Pab-097690	Pongo abelii	54.45	0.00e+00	1405.00
IUUC-Pca-100778	Procavia capensis	43.21	0.00e+00	687.00
IUUC-Pva-102870	Pteropus vampyrus	52.87	0.00e+00	1244.00
IUUC-Rno-104889	Rattus norvegicus	54.13	0.00e+00	1386.00
IUUC-Sha-107465	Sarcophilus harrisii	55.27	0.00e+00	1408.00
IUUC-Sar-113268	Sorex araneus	50.42	6.00e-103	369.00
IUUC-Ssc-115654	Sus scrofa	54.13	0.00e+00	1406.00
IUUC-Tgu-117302	Taeniopygia guttata	54.07	0.00e+00	1384.00
IUUC-Tsy-119007	Tarsius syrichta	52.23	0.00e+00	1326.00
IUUC-Tni-120910	Tetraodon nigroviridis	88.73	0.00e+00	2227.00
IUUC-Tbe-127413	Tupaia belangeri	45.13	0.00e+00	798.00
IUUC-Ttr-129213	Tursiops truncatus	50.72	0.00e+00	1256.00
IUUC-Vpa-130146	Vicugna pacos	49.31	0.00e+00	920.00
IUUC-Xtr-132559	Xenopus tropicalis	50.16	0.00e+00	1281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence