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Tag Content
iUUCD ID IUUC-Pab-098202
Ensembl Protein ID ENSPPYP00000018470.1
UniProt Accession Q5R411; Q5R9R0; PACN1_PONAB
Genbank Protein ID CAH91500.1; CAH93505.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 1
Genbank Nucleotide ID CR859322; CR861449
Gene Name Pacsin1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000016517.1 ENSPPYT00000019207.1 ENSPPYP00000018470.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 3.50e-15 55.8 389 444
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lydy++q++deL++k+Gd ++ +  ee ++gW++g + ++g+ Gl P+n+ve +
   Q: 389  RVRALYDYDGQEQDELSFKAGDELTKL-GEEDEQGWCRG-RLDSGQLGLYPANYVEAI 444
           699************************.***********.59*************975 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
 Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
Protein Sequence
(Fasta)
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL 60
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA 120
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Protein Fasta Sequence


>IUUC-Pab-098202|UBD,SH3|Pongo abelii
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Nucleotide Sequence
(Fasta)
GGGAGTGGGG AGGAGGCAGC GGTGGAGGGA GCTGGCTCCT GCAGTTCTGG CGCTGCTGCC 60
TTCCTGAGTG AGCGGTGGAG GGAACTCTAG AGGACAGAGC CCCCAGCCCG GCACCAGGCC 120
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Nucleotide Fasta Sequence


>IUUC-Pab-098202|UBD,SH3|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028518--PACSIN1
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0043679--C:axon terminus
GO:0030054--C:cell junction
GO:0030137--C:COPI-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0043209--C:myelin sheath
GO:0032587--C:ruffle membrane
GO:0005543--F:phospholipid binding
GO:0007015--P:actin filament organization
GO:0045806--P:negative regulation of endocytosis
GO:0048812--P:neuron projection morphogenesis
GO:0097320--P:plasma membrane tubulation
GO:0072657--P:protein localization to membrane
GO:0048488--P:synaptic vesicle endocytosis
KEGG pon:100172814
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001861 Ailuropoda melanoleuca 87.50 0.00e+00 773.00
IUUC-Apl-003667 Anas platyrhynchos 83.72 0.00e+00 697.00
IUUC-Aca-005229 Anolis carolinensis 81.39 0.00e+00 716.00
IUUC-Ame-011410 Astyanax mexicanus 74.44 2.00e-180 625.00
IUUC-Bta-013509 Bos taurus 94.14 0.00e+00 749.00
IUUC-Cel-018168 Caenorhabditis elegans 28.87 1.00e-59 224.00
IUUC-Cja-019659 Callithrix jacchus 98.65 0.00e+00 838.00
IUUC-Cfa-020396 Canis familiaris 96.85 0.00e+00 799.00
IUUC-Cpo-022376 Cavia porcellus 97.07 0.00e+00 798.00
IUUC-Csa-023701 Chlorocebus sabaeus 99.32 0.00e+00 814.00
IUUC-Cin-025707 Ciona intestinalis 44.92 1.00e-104 373.00
IUUC-Dre-027456 Danio rerio 75.39 0.00e+00 677.00
IUUC-Dno-029429 Dasypus novemcinctus 62.42 1.00e-160 560.00
IUUC-Dor-030122 Dipodomys ordii 63.97 3.00e-163 568.00
IUUC-Dme-032120 Drosophila melanogaster 44.82 1.00e-80 293.00
IUUC-Eca-033679 Equus caballus 90.38 0.00e+00 724.00
IUUC-Fca-036314 Felis catus 96.85 0.00e+00 801.00
IUUC-Fal-037300 Ficedula albicollis 85.20 0.00e+00 739.00
IUUC-Gmo-038571 Gadus morhua 68.36 7.00e-164 570.00
IUUC-Gga-040626 Gallus gallus 85.65 0.00e+00 692.00
IUUC-Gac-041445 Gasterosteus aculeatus 70.09 1.00e-168 585.00
IUUC-Ggo-045557 Gorilla gorilla 99.55 0.00e+00 817.00
IUUC-Hsa-045778 Homo sapiens 99.55 0.00e+00 817.00
IUUC-Itr-048856 Ictidomys tridecemlineatus 97.75 0.00e+00 804.00
IUUC-Lch-050070 Latimeria chalumnae 71.49 0.00e+00 669.00
IUUC-Loc-051764 Lepisosteus oculatus 79.42 0.00e+00 696.00
IUUC-Laf-054465 Loxodonta africana 94.83 0.00e+00 799.00
IUUC-Mcc-055324 Macaca mulatta 99.10 0.00e+00 815.00
IUUC-Meu-056348 Macropus eugenii 90.32 0.00e+00 742.00
IUUC-Mga-059285 Meleagris gallopavo 85.92 0.00e+00 679.00
IUUC-Mmr-061367 Microcebus murinus 97.07 0.00e+00 753.00
IUUC-Mdo-062432 Monodelphis domestica 57.94 7.00e-139 486.00
IUUC-Mmu-064347 Mus musculus 95.05 0.00e+00 821.00
IUUC-Mpu-066864 Mustela putorius furo 97.07 0.00e+00 801.00
IUUC-Nle-070027 Nomascus leucogenys 99.29 0.00e+00 771.00
IUUC-Ont-072188 Oreochromis niloticus 72.48 0.00e+00 639.00
IUUC-Ocu-074297 Oryctolagus cuniculus 96.85 0.00e+00 766.00
IUUC-Ola-087188 Oryzias latipes 72.48 4.00e-163 567.00
IUUC-Oga-088856 Otolemur garnettii 98.20 0.00e+00 780.00
IUUC-Oar-090278 Ovis aries 86.94 0.00e+00 650.00
IUUC-Pan-092056 Papio anubis 99.32 0.00e+00 814.00
IUUC-Psi-093704 Pelodiscus sinensis 64.32 2.00e-163 568.00
IUUC-Pfo-097528 Poecilia formosa 69.57 2.00e-157 548.00
IUUC-Pca-100881 Procavia capensis 96.17 0.00e+00 787.00
IUUC-Pva-102181 Pteropus vampyrus 97.30 0.00e+00 800.00
IUUC-Rno-105295 Rattus norvegicus 92.34 0.00e+00 766.00
IUUC-Sha-107163 Sarcophilus harrisii 76.42 0.00e+00 654.00
IUUC-Ssc-115685 Sus scrofa 96.17 0.00e+00 794.00
IUUC-Tgu-116524 Taeniopygia guttata 78.03 0.00e+00 648.00
IUUC-Tru-118248 Takifugu rubripes 69.64 8.00e-155 540.00
IUUC-Tni-120717 Tetraodon nigroviridis 70.47 7.00e-159 553.00
IUUC-Ttr-129069 Tursiops truncatus 95.51 0.00e+00 745.00
IUUC-Xtr-132759 Xenopus tropicalis 71.14 0.00e+00 649.00
Created Date 25-Jun-2017

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