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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045773
Ensembl Protein ID ENSP00000216879.4
UniProt Accession Q9UNZ2; A2A2L1; B2RD74; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; NSF1C_HUMAN
Genbank Protein ID AAP97139.1; AAF17199.1; AAD44488.1; BAG59842.1; BAA91731.1; BAG37821.1; CAB96827.1; CAI22730.1; CAI22731.1; CAM28306.1; EAX10629.1; EAX10631.1; AAH02801.1
Protein Name NSFL1 cofactor p47; UBX domain-containing protein 2C; p97 cofactor p47
Genbank Nucleotide ID AF086909; AF112211; AF078856; AK297403; AK001511; AK315433; AL109658; AL109658; AL109658; AL109658; CH471133; CH471133; BC002801
Gene Name NSFL1C; UBXN2C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000088833.17 ENST00000353088.6 ENSP00000338643.2
ENSG00000088833.17 ENST00000476071.5 ENSP00000418529.1
ENSG00000088833.17 ENST00000216879.8 ENSP00000216879.4
ENSG00000088833.17 ENST00000381653.9 ENSP00000434067.1
ENSG00000088833.17 ENST00000470376.5 ENSP00000473400.1
ENSG00000088833.17 ENST00000489203.2 ENSP00000473616.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 12411482
ULD/UDP/UFD/UBX UBX 11243799; 14988733
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 7.40e-05 24.4 4 43
ULD/UDP/UFD/UBX 7.90e-17 63.2 292 367
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLld 40
           e++++l+++v+ +G ++++a+  L++a+++l+ A++ +++
   Q: 4    ERQEALREFVAvTGAEEDRARFFLESAGWDLQIALASFYE 43
           6899*******************************99875 PP
   

   ULD/UDP/UFD/UBX
   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsll 78
           +++++++qiRl+dG rlv+kF++s+++++i+ f+   +  +  + F L+++fP+++l++e++  tl+ea+L++  +++
   Q: 292  SEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVdARPAMAATSFILMTTFPNKELADESQ--TLKEANLLNAVIVQ 367
           5779*******************************9999***********************..*********99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).
 Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).
Protein Sequence
(Fasta)
MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS 60
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045773|UBD,UBA;ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAAGCTGA AACAGCAGGA AAGCATGGAG GTGGTTCTCC ACTAACTGGA GGTGGGTCCC 60
ACCTGCCCTT GCAAGCCCCC TAGCCCTGTA GGGCCCTGCA TGAGCTGGTC CCTGCCACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045773|UBD,UBA;ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR012989--SEP_domain
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS51399--SEP
PS50033--UBX
Pfam

PF08059--SEP
PF00789--UBX
SMART

SM00553--SEP
SM00166--UBX
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005795--C:Golgi stack
GO:0045111--C:intermediate filament cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:1990730--C:VCP-NSFL1C complex
GO:0005543--F:phospholipid binding
GO:0043130--F:ubiquitin binding
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG hsa:55968
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000550 Aegilops tauschii 37.09 2.00e-36 145.00
IUUC-Aml-001919 Ailuropoda melanoleuca 95.72 0.00e+00 704.00
IUUC-Atr-002543 Amborella trichopoda 31.25 2.00e-40 159.00
IUUC-Apl-003388 Anas platyrhynchos 87.68 0.00e+00 635.00
IUUC-Aca-005210 Anolis carolinensis 87.47 0.00e+00 649.00
IUUC-Aly-006329 Arabidopsis lyrata 35.71 3.00e-37 149.00
IUUC-Ath-007064 Arabidopsis thaliana 35.92 5.00e-36 144.00
IUUC-Ago-007933 Ashbya gossypii 28.18 3.00e-19 89.70
IUUC-Afu-008919 Aspergillus fumigatus 39.69 3.00e-29 122.00
IUUC-Ani-009398 Aspergillus nidulans 31.87 1.00e-40 160.00
IUUC-Ang-009594 Aspergillus niger 29.00 6.00e-32 131.00
IUUC-Ate-010455 Aspergillus terreus 34.84 8.00e-35 141.00
IUUC-Ame-011089 Astyanax mexicanus 72.97 2.00e-150 525.00
IUUC-Bgr-012256 Blumeria graminis 29.04 1.00e-27 117.00
IUUC-Bta-012898 Bos taurus 96.76 0.00e+00 718.00
IUUC-Bci-013750 Botrytis cinerea 33.46 1.00e-30 127.00
IUUC-Bdi-014746 Brachypodium distachyon 34.77 5.00e-37 148.00
IUUC-Bol-015874 Brassica oleracea 30.91 4.00e-37 149.00
IUUC-Bra-017734 Brassica rapa 37.10 1.00e-35 143.00
IUUC-Cel-018169 Caenorhabditis elegans 39.17 3.00e-38 152.00
IUUC-Cja-018993 Callithrix jacchus 99.19 0.00e+00 728.00
IUUC-Cfa-020958 Canis familiaris 97.03 0.00e+00 720.00
IUUC-Cpo-021417 Cavia porcellus 97.84 0.00e+00 722.00
IUUC-Csa-023244 Chlorocebus sabaeus 99.46 0.00e+00 733.00
IUUC-Cho-024335 Choloepus hoffmanni 73.76 2.00e-97 348.00
IUUC-Cin-025686 Ciona intestinalis 47.30 4.00e-92 331.00
IUUC-Csv-025945 Ciona savignyi 44.96 7.00e-88 317.00
IUUC-Cne-026798 Cryptococcus neoformans 38.42 2.00e-36 146.00
IUUC-Cme-027347 Cyanidioschyzon merolae 32.87 8.00e-30 124.00
IUUC-Dre-028748 Danio rerio 72.70 2.00e-149 522.00
IUUC-Dno-029977 Dasypus novemcinctus 95.70 0.00e+00 709.00
IUUC-Dor-030203 Dipodomys ordii 96.14 0.00e+00 640.00
IUUC-Dse-031256 Dothistroma septosporum 31.80 1.00e-31 130.00
IUUC-Dme-031878 Drosophila melanogaster 44.41 3.00e-60 225.00
IUUC-Ete-032997 Echinops telfairi 94.32 0.00e+00 697.00
IUUC-Eca-034132 Equus caballus 97.62 0.00e+00 657.00
IUUC-Eeu-035097 Erinaceus europaeus 71.56 6.00e-84 304.00
IUUC-Fca-036037 Felis catus 96.46 0.00e+00 649.00
IUUC-Fal-037100 Ficedula albicollis 87.03 4.00e-175 607.00
IUUC-Fso-038190 Fusarium solani 27.23 4.00e-31 129.00
IUUC-Gmo-039429 Gadus morhua 65.85 4.00e-131 461.00
IUUC-Gga-040864 Gallus gallus 88.32 0.00e+00 660.00
IUUC-Gac-041589 Gasterosteus aculeatus 69.97 5.00e-147 513.00
IUUC-Gma-044296 Glycine max 35.59 1.00e-36 147.00
IUUC-Ggo-044601 Gorilla gorilla 99.46 0.00e+00 730.00
IUUC-Itr-047949 Ictidomys tridecemlineatus 96.51 0.00e+00 716.00
IUUC-Kpa-049322 Komagataella pastoris 32.37 4.00e-29 122.00
IUUC-Lch-050608 Latimeria chalumnae 74.32 2.00e-161 561.00
IUUC-Lpe-050944 Leersia perrieri 35.58 4.00e-32 133.00
IUUC-Loc-052555 Lepisosteus oculatus 73.64 1.00e-158 552.00
IUUC-Laf-054237 Loxodonta africana 95.70 0.00e+00 710.00
IUUC-Mcc-055472 Macaca mulatta 99.19 0.00e+00 728.00
IUUC-Meu-056093 Macropus eugenii 72.78 2.00e-125 442.00
IUUC-Mor-057220 Magnaporthe oryzae 25.88 9.00e-30 124.00
IUUC-Mtr-058376 Medicago truncatula 35.34 5.00e-35 141.00
IUUC-Mla-059077 Melampsora laricipopulina 33.02 3.00e-35 142.00
IUUC-Mga-059836 Meleagris gallopavo 87.94 1.00e-174 605.00
IUUC-Mvi-060292 Microbotryum violaceum 38.74 2.00e-32 133.00
IUUC-Mmr-060897 Microcebus murinus 96.51 0.00e+00 714.00
IUUC-Mdo-062066 Monodelphis domestica 90.74 0.00e+00 679.00
IUUC-Mmu-063686 Mus musculus 95.70 0.00e+00 711.00
IUUC-Mac-065403 Musa acuminata 32.53 3.00e-33 136.00
IUUC-Mpu-065688 Mustela putorius furo 97.30 0.00e+00 722.00
IUUC-Mlu-067566 Myotis lucifugus 93.80 0.00e+00 677.00
IUUC-Nle-069169 Nomascus leucogenys 99.41 0.00e+00 666.00
IUUC-Opr-070979 Ochotona princeps 93.20 6.00e-178 616.00
IUUC-Ont-071803 Oreochromis niloticus 68.55 6.00e-145 506.00
IUUC-Ocu-074276 Oryctolagus cuniculus 97.04 0.00e+00 718.00
IUUC-Oba-075011 Oryza barthii 34.89 3.00e-34 138.00
IUUC-Obr-076164 Oryza brachyantha 35.64 4.00e-28 118.00
IUUC-Ogl-077805 Oryza glaberrima 34.89 3.00e-34 138.00
IUUC-Ogu-078942 Oryza glumaepatula 34.89 3.00e-34 139.00
IUUC-Oin-079497 Oryza indica 34.33 2.00e-31 130.00
IUUC-Olo-080254 Oryza longistaminata 39.57 7.00e-31 128.00
IUUC-Oni-082258 Oryza nivara 34.89 3.00e-34 138.00
IUUC-Oru-084748 Oryza rufipogon 34.89 3.00e-34 139.00
IUUC-Osa-085359 Oryza sativa 34.89 3.00e-34 138.00
IUUC-Ola-086761 Oryzias latipes 69.35 1.00e-139 489.00
IUUC-Olu-087598 Ostreococcus lucimarinus 33.80 1.00e-32 134.00
IUUC-Oga-088533 Otolemur garnettii 98.38 0.00e+00 726.00
IUUC-Oar-089450 Ovis aries 97.03 0.00e+00 719.00
IUUC-Ptr-090926 Pan troglodytes 100.00 0.00e+00 735.00
IUUC-Pan-092100 Papio anubis 99.73 0.00e+00 733.00
IUUC-Psi-093446 Pelodiscus sinensis 86.05 2.00e-166 578.00
IUUC-Pma-094475 Petromyzon marinus 65.95 1.00e-104 372.00
IUUC-Pno-094769 Phaeosphaeria nodorum 33.11 5.00e-36 145.00
IUUC-Ppa-095833 Physcomitrella patens 34.64 5.00e-36 145.00
IUUC-Pfo-096193 Poecilia formosa 70.51 6.00e-150 523.00
IUUC-Pab-097971 Pongo abelii 100.00 0.00e+00 735.00
IUUC-Pop-098970 Populus trichocarpa 36.79 2.00e-43 169.00
IUUC-Pca-100390 Procavia capensis 94.98 4.00e-126 443.00
IUUC-Pva-102504 Pteropus vampyrus 87.90 0.00e+00 639.00
IUUC-Pgr-103447 Puccinia graminis 30.57 7.00e-34 138.00
IUUC-Ptt-103729 Puccinia triticina 32.59 1.00e-36 147.00
IUUC-Pte-104083 Pyrenophora teres 33.90 2.00e-40 159.00
IUUC-Pyt-104504 Pyrenophora triticirepentis 32.88 5.00e-36 145.00
IUUC-Rno-105448 Rattus norvegicus 96.49 0.00e+00 718.00
IUUC-Sce-106457 Saccharomyces cerevisiae 30.77 1.00e-30 127.00
IUUC-Sja-107717 Schizosaccharomyces japonicus 33.68 3.00e-31 129.00
IUUC-Spo-108358 Schizosaccharomyces pombe 29.95 2.00e-33 137.00
IUUC-Smo-109535 Selaginella moellendorffii 35.49 7.00e-34 137.00
IUUC-Sit-110328 Setaria italica 35.19 4.00e-35 142.00
IUUC-Sly-111135 Solanum lycopersicum 31.94 2.00e-41 163.00
IUUC-Stu-112733 Solanum tuberosum 35.00 9.00e-38 150.00
IUUC-Sar-113445 Sorex araneus 77.96 2.00e-127 448.00
IUUC-Sbi-114761 Sorghum bicolor 35.99 1.00e-33 137.00
IUUC-Sre-115176 Sporisorium reilianum 39.69 4.00e-31 129.00
IUUC-Ssc-116008 Sus scrofa 97.84 0.00e+00 723.00
IUUC-Tgu-117238 Taeniopygia guttata 88.04 0.00e+00 656.00
IUUC-Tru-118521 Takifugu rubripes 64.15 7.00e-137 480.00
IUUC-Tni-119705 Tetraodon nigroviridis 67.56 8.00e-141 493.00
IUUC-Tca-121370 Theobroma cacao 33.57 4.00e-29 122.00
IUUC-Tre-121941 Trichoderma reesei 34.34 4.00e-30 125.00
IUUC-Tvi-122602 Trichoderma virens 27.59 6.00e-28 118.00
IUUC-Tae-123686 Triticum aestivum 37.81 8.00e-39 154.00
IUUC-Tur-126267 Triticum urartu 37.81 2.00e-33 135.00
IUUC-Tme-127193 Tuber melanosporum 31.90 5.00e-38 152.00
IUUC-Tbe-127716 Tupaia belangeri 95.39 1.00e-163 568.00
IUUC-Ttr-128262 Tursiops truncatus 95.43 0.00e+00 702.00
IUUC-Uma-129600 Ustilago maydis 30.43 1.00e-41 164.00
IUUC-Vda-129743 Verticillium dahliae 29.62 6.00e-30 125.00
IUUC-Vpa-130068 Vicugna pacos 96.75 5.00e-170 590.00
IUUC-Vvi-131338 Vitis vinifera 33.09 1.00e-33 136.00
IUUC-Xma-133944 Xiphophorus maculatus 70.24 4.00e-150 524.00
IUUC-Zma-135978 Zea mays 35.66 2.00e-34 139.00
Created Date 25-Jun-2017

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