iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033809

Ensembl Protein ID

ENSECAP00000019222.1

UniProt Accession

F6Y6N2; F6Y6N2_HORSE

Protein Name

Phosphoinositide phospholipase C

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021031.1	ENSECAT00000023225.1	ENSECAP00000019222.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.90e-12	45.8	720	777

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve++
   Q: 720  FKCAVKALFDYKAQREDELTFTKSAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEM 777
           56789************************9..9*********..676666655******985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

VDIREIKEIR PGKTSRDFDR YQEDPAFRPD QSHCFVILYG MEFRLKTLSL QATSEEEVNM 60
WIKGLTWLME DTLQAATPLQ IERWLRKQFY SVDRNREDRI SAKDLKNMLS QVNYRVPNMR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGACATTC GTGAAATCAA GGAGATACGC CCAGGGAAGA CCTCTCGGGA CTTTGATCGC 60
TACCAAGAGG ACCCTGCTTT CCGACCAGAT CAGTCGCACT GCTTTGTCAT CCTGTATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001701--P:in utero embryonic development
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	98.61	0.00e+00	2462.00
IUUC-Apl-003541	Anas platyrhynchos	70.23	0.00e+00	1691.00
IUUC-Aca-005291	Anolis carolinensis	86.64	0.00e+00	2154.00
IUUC-Ame-011004	Astyanax mexicanus	69.47	0.00e+00	1714.00
IUUC-Bta-012660	Bos taurus	98.36	0.00e+00	2465.00
IUUC-Cja-019206	Callithrix jacchus	97.95	0.00e+00	2450.00
IUUC-Cfa-020257	Canis familiaris	99.02	0.00e+00	2472.00
IUUC-Cpo-022391	Cavia porcellus	92.11	0.00e+00	2275.00
IUUC-Csa-024170	Chlorocebus sabaeus	97.92	0.00e+00	1754.00
IUUC-Cin-025520	Ciona intestinalis	48.39	0.00e+00	1068.00
IUUC-Dre-027944	Danio rerio	72.85	0.00e+00	1796.00
IUUC-Dno-029440	Dasypus novemcinctus	97.54	0.00e+00	2359.00
IUUC-Dor-031001	Dipodomys ordii	96.97	0.00e+00	2433.00
IUUC-Fca-036510	Felis catus	98.20	0.00e+00	2457.00
IUUC-Fal-037541	Ficedula albicollis	88.10	0.00e+00	2106.00
IUUC-Gmo-038630	Gadus morhua	68.77	0.00e+00	1384.00
IUUC-Gga-040142	Gallus gallus	88.84	0.00e+00	2216.00
IUUC-Ggo-045063	Gorilla gorilla	98.20	0.00e+00	2463.00
IUUC-Hsa-046428	Homo sapiens	98.11	0.00e+00	2460.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	97.46	0.00e+00	2446.00
IUUC-Lch-049766	Latimeria chalumnae	80.25	0.00e+00	1968.00
IUUC-Loc-052285	Lepisosteus oculatus	77.83	0.00e+00	1954.00
IUUC-Laf-053365	Loxodonta africana	97.05	0.00e+00	2428.00
IUUC-Mcc-054871	Macaca mulatta	97.21	0.00e+00	2431.00
IUUC-Meu-056724	Macropus eugenii	89.43	0.00e+00	2199.00
IUUC-Mga-059329	Meleagris gallopavo	87.83	0.00e+00	2179.00
IUUC-Mmr-061110	Microcebus murinus	97.46	0.00e+00	2434.00
IUUC-Mdo-062448	Monodelphis domestica	94.50	0.00e+00	2384.00
IUUC-Mmu-063565	Mus musculus	97.34	0.00e+00	2429.00
IUUC-Mpu-066683	Mustela putorius furo	98.44	0.00e+00	2460.00
IUUC-Mlu-067779	Myotis lucifugus	97.62	0.00e+00	2437.00
IUUC-Nle-069219	Nomascus leucogenys	97.35	0.00e+00	2122.00
IUUC-Opr-070766	Ochotona princeps	93.90	0.00e+00	1456.00
IUUC-Ont-072524	Oreochromis niloticus	74.37	0.00e+00	1872.00
IUUC-Oan-073214	Ornithorhynchus anatinus	93.48	3.00e-47	180.00
IUUC-Ocu-074361	Oryctolagus cuniculus	96.32	0.00e+00	2405.00
IUUC-Ola-086820	Oryzias latipes	73.64	0.00e+00	1889.00
IUUC-Oga-088172	Otolemur garnettii	98.36	0.00e+00	2462.00
IUUC-Oar-090306	Ovis aries	95.08	0.00e+00	2373.00
IUUC-Ptr-090682	Pan troglodytes	98.11	0.00e+00	2461.00
IUUC-Pan-092835	Papio anubis	97.93	0.00e+00	1836.00
IUUC-Psi-093344	Pelodiscus sinensis	86.46	0.00e+00	2175.00
IUUC-Pfo-096984	Poecilia formosa	72.42	0.00e+00	1828.00
IUUC-Pab-097871	Pongo abelii	97.87	0.00e+00	2458.00
IUUC-Pop-099175	Populus trichocarpa	22.66	3.60e-01	29.30
IUUC-Pca-100772	Procavia capensis	90.65	0.00e+00	2235.00
IUUC-Pva-102790	Pteropus vampyrus	98.48	0.00e+00	2410.00
IUUC-Rno-105974	Rattus norvegicus	97.54	0.00e+00	2445.00
IUUC-Sit-109753	Setaria italica	43.24	5.90e-01	29.30
IUUC-Sar-112995	Sorex araneus	95.57	0.00e+00	2378.00
IUUC-Ssc-115360	Sus scrofa	97.95	0.00e+00	2449.00
IUUC-Tgu-116585	Taeniopygia guttata	85.89	0.00e+00	2092.00
IUUC-Tru-117742	Takifugu rubripes	74.32	0.00e+00	1894.00
IUUC-Tsy-119259	Tarsius syrichta	98.10	0.00e+00	863.00
IUUC-Tni-120833	Tetraodon nigroviridis	67.80	0.00e+00	1647.00
IUUC-Tbe-127504	Tupaia belangeri	83.83	0.00e+00	1412.00
IUUC-Ttr-128650	Tursiops truncatus	98.15	0.00e+00	1196.00
IUUC-Xtr-132862	Xenopus tropicalis	77.97	0.00e+00	1899.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence