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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063119
UUCD1 version UUC-MuM-00732
Ensembl Protein ID ENSMUSP00000054963.3
UniProt Accession Q8CE33; Q3TDZ6; Q91VP6; KLH11_MOUSE
Genbank Protein ID BAC26297.1; BAE41452.1; AAH11167.1
Protein Name Kelch-like protein 11
Genbank Nucleotide ID AK029101; AK169910; BC011167
Gene Name Klhl11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048732.5 ENSMUST00000056665.3 ENSMUSP00000054963.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.50e-15 58.4 95 169
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.60e-09 36.9 203 233
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg...geeffahkivLaasSsvFyalflmeleesksklmveikd......vqpevfrallkFlYtgklde 67
           +D++l+ g   g+ef+ah++vLaa+ ++F  l++++++es+ +++ve++        +p+ ++a+++++Ytg+++ 
   Q: 95   CDITLCFGgagGREFRAHRSVLAAATEYFTPLLSGQFSESR-SGRVEMRKwssepgPEPDTVEAVIEYMYTGRIRV 169
           8******7788******************************.*******4456799*****************975 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           l+Nc++i ++A++y++++L+++a d+i ++F
   Q: 203  LSNCVAIHSLAHMYTLSQLALKAADMIRRNF 233
           69****************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
Protein Sequence
(Fasta)
MAAAVAAAAA AAAAAASFQV LEMESMETAV AGSASLAAEV RGSGTVDFVT GAGISTLVDT 60
GGSDPGPEAE DFECSTHCSE LSWRQNEQRR QGLFCDITLC FGGAGGREFR AHRSVLAAAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063119|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCGGCGTC AAGATGGCGG CGGCTGTGGC GGCGGCAGCT GCCGCTGCGG CCGCGGCTGC 60
ATCTTTTCAA GTGCTGGAGA TGGAGAGCAT GGAGACTGCC GTCGCCGGTT CCGCGAGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063119|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG mmu:217194
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002239 Ailuropoda melanoleuca 95.64 0.00e+00 1326.00
IUUC-Apl-003928 Anas platyrhynchos 84.42 0.00e+00 1042.00
IUUC-Aca-004801 Anolis carolinensis 82.12 0.00e+00 1108.00
IUUC-Ame-010943 Astyanax mexicanus 76.01 0.00e+00 908.00
IUUC-Bta-012341 Bos taurus 99.40 4.00e-97 346.00
IUUC-Cja-019924 Callithrix jacchus 96.68 0.00e+00 1385.00
IUUC-Cfa-021076 Canis familiaris 96.83 0.00e+00 1390.00
IUUC-Cpo-022193 Cavia porcellus 91.49 0.00e+00 1294.00
IUUC-Csa-023614 Chlorocebus sabaeus 96.94 0.00e+00 1377.00
IUUC-Cho-024806 Choloepus hoffmanni 82.67 0.00e+00 928.00
IUUC-Dre-028622 Danio rerio 75.16 0.00e+00 997.00
IUUC-Dno-029965 Dasypus novemcinctus 94.12 0.00e+00 1346.00
IUUC-Dor-030136 Dipodomys ordii 97.72 0.00e+00 1089.00
IUUC-Eca-034191 Equus caballus 94.93 0.00e+00 1334.00
IUUC-Eeu-034746 Erinaceus europaeus 95.24 0.00e+00 1367.00
IUUC-Fca-035702 Felis catus 90.45 0.00e+00 1253.00
IUUC-Fal-037360 Ficedula albicollis 83.68 0.00e+00 1027.00
IUUC-Gmo-038582 Gadus morhua 74.81 0.00e+00 1008.00
IUUC-Ggr-039747 Gaeumannomyces graminis 25.93 2.00e-08 52.80
IUUC-Gga-040375 Gallus gallus 83.54 0.00e+00 1128.00
IUUC-Gac-042523 Gasterosteus aculeatus 76.59 0.00e+00 1001.00
IUUC-Ggo-045632 Gorilla gorilla 98.30 0.00e+00 1095.00
IUUC-Hsa-046817 Homo sapiens 96.83 0.00e+00 1386.00
IUUC-Itr-048433 Ictidomys tridecemlineatus 96.97 0.00e+00 1391.00
IUUC-Lch-049985 Latimeria chalumnae 78.71 0.00e+00 1036.00
IUUC-Loc-052594 Lepisosteus oculatus 76.18 0.00e+00 996.00
IUUC-Lma-053111 Leptosphaeria maculans 31.65 1.00e-04 40.00
IUUC-Laf-054357 Loxodonta africana 96.83 0.00e+00 1391.00
IUUC-Mcc-055454 Macaca mulatta 97.70 0.00e+00 1345.00
IUUC-Meu-056012 Macropus eugenii 87.82 3.00e-175 607.00
IUUC-Mga-060048 Meleagris gallopavo 84.52 0.00e+00 859.00
IUUC-Mdo-062082 Monodelphis domestica 88.22 0.00e+00 1286.00
IUUC-Mpu-066511 Mustela putorius furo 96.68 0.00e+00 1389.00
IUUC-Mlu-067301 Myotis lucifugus 94.81 0.00e+00 1343.00
IUUC-Nfi-068503 Neosartorya fischeri 33.33 8.00e-03 34.30
IUUC-Nle-069912 Nomascus leucogenys 96.83 0.00e+00 1386.00
IUUC-Opr-070762 Ochotona princeps 97.53 0.00e+00 837.00
IUUC-Ont-071916 Oreochromis niloticus 77.36 0.00e+00 996.00
IUUC-Oan-072932 Ornithorhynchus anatinus 77.04 0.00e+00 823.00
IUUC-Ocu-074172 Oryctolagus cuniculus 98.08 0.00e+00 1083.00
IUUC-Ola-086483 Oryzias latipes 77.21 0.00e+00 992.00
IUUC-Oga-088112 Otolemur garnettii 95.70 0.00e+00 1323.00
IUUC-Oar-090129 Ovis aries 96.68 0.00e+00 1388.00
IUUC-Ptr-090571 Pan troglodytes 98.29 0.00e+00 1095.00
IUUC-Pan-092073 Papio anubis 96.68 0.00e+00 1385.00
IUUC-Psi-093836 Pelodiscus sinensis 85.74 0.00e+00 1082.00
IUUC-Pno-095007 Phaeosphaeria nodorum 31.08 8.00e-05 41.20
IUUC-Pfo-096477 Poecilia formosa 77.21 0.00e+00 994.00
IUUC-Pab-098473 Pongo abelii 96.68 0.00e+00 1385.00
IUUC-Pca-100239 Procavia capensis 94.91 0.00e+00 822.00
IUUC-Pyt-104638 Pyrenophora triticirepentis 38.10 7.00e-05 41.20
IUUC-Rno-104859 Rattus norvegicus 99.57 0.00e+00 1451.00
IUUC-Sha-106746 Sarcophilus harrisii 87.18 0.00e+00 1268.00
IUUC-Ssl-108438 Sclerotinia sclerotiorum 38.10 1.00e-05 43.50
IUUC-Tgu-117183 Taeniopygia guttata 83.02 0.00e+00 1129.00
IUUC-Tru-118655 Takifugu rubripes 75.61 0.00e+00 988.00
IUUC-Tsy-119430 Tarsius syrichta 98.12 0.00e+00 1328.00
IUUC-Tni-119698 Tetraodon nigroviridis 76.43 0.00e+00 869.00
IUUC-Vda-129848 Verticillium dahliae 33.33 1.00e-03 37.40
IUUC-Vpa-130715 Vicugna pacos 95.51 0.00e+00 1373.00
IUUC-Xtr-132276 Xenopus tropicalis 77.41 0.00e+00 997.00
Created Date 25-Jun-2017

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