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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046418
Ensembl Protein ID ENSP00000451000.1
UniProt Accession Q9Y2K1; A8K6S8; Q86SW8; ZBTB1_HUMAN
Genbank Protein ID BAF84432.1; BAA76841.2; AAH50719.1; CAD66584.1
Protein Name Zinc finger and BTB domain-containing protein 1
Genbank Nucleotide ID AK291743; AB023214; AL049869; BX248777
Gene Name ZBTB1; KIAA0997
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000126804.13 ENST00000554015.5 ENSP00000451000.1
ENSG00000126804.13 ENST00000358738.3 ENSP00000351587.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.30e-12 48.8 24 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D+++ +++ +f+ahk+vLaa+Ss+F+  f +++ +  +  +  ++k +++e+f  +l+F+Y gk+
   Q: 24   CDCCIAIDDIYFQAHKAVLAACSSYFRMFFmNHQHSTAQ-LNLSNMK-ISAECFDLILQFMYLGKI 87
           8*************************9999333333333.5555666.****************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
 Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
Protein Sequence
(Fasta)
MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST 60
AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046418|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCCAAGCCG CGCACTGCAA GCAGTGGCGC CGGCTCACGC ACCCCTCGGC CGCCTCTCGC 60
GCGGCTTCCC GCGCCGGCAG CCCGCGATGG CCCCACGTGA CCGCGTGTCT GGTAGCAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046418|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0030183--P:B cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0045087--P:innate immune response
GO:0042789--P:mRNA transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032825--P:positive regulation of natural killer cell differentiation
GO:2000176--P:positive regulation of pro-T cell differentiation
GO:0045582--P:positive regulation of T cell differentiation
GO:0002711--P:positive regulation of T cell mediated immunity
GO:0051260--P:protein homooligomerization
GO:0033077--P:T cell differentiation in thymus
GO:0048538--P:thymus development
GO:0019985--P:translesion synthesis
KEGG hsa:22890
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001844 Ailuropoda melanoleuca 97.05 0.00e+00 1352.00
IUUC-Apl-003725 Anas platyrhynchos 82.27 0.00e+00 1134.00
IUUC-Aca-004672 Anolis carolinensis 71.78 0.00e+00 952.00
IUUC-Ame-011859 Astyanax mexicanus 48.57 3.00e-179 622.00
IUUC-Bta-013323 Bos taurus 98.04 0.00e+00 1414.00
IUUC-Cja-018727 Callithrix jacchus 99.02 0.00e+00 1375.00
IUUC-Cfa-020390 Canis familiaris 97.05 0.00e+00 1360.00
IUUC-Cpo-022434 Cavia porcellus 96.35 0.00e+00 1385.00
IUUC-Csa-023909 Chlorocebus sabaeus 98.89 0.00e+00 1181.00
IUUC-Cho-024288 Choloepus hoffmanni 96.88 0.00e+00 954.00
IUUC-Dre-027623 Danio rerio 47.62 3.00e-179 622.00
IUUC-Dno-029224 Dasypus novemcinctus 98.04 0.00e+00 1412.00
IUUC-Ete-032672 Echinops telfairi 93.24 0.00e+00 989.00
IUUC-Eca-034361 Equus caballus 97.94 0.00e+00 1194.00
IUUC-Eeu-035254 Erinaceus europaeus 90.58 4.00e-157 548.00
IUUC-Fca-036217 Felis catus 96.77 0.00e+00 1394.00
IUUC-Fal-037026 Ficedula albicollis 78.16 0.00e+00 958.00
IUUC-Gga-040550 Gallus gallus 77.08 1.00e-142 499.00
IUUC-Gac-041379 Gasterosteus aculeatus 45.93 8.00e-170 590.00
IUUC-Ggo-044852 Gorilla gorilla 99.86 0.00e+00 1432.00
IUUC-Itr-048065 Ictidomys tridecemlineatus 97.19 0.00e+00 1395.00
IUUC-Lch-050025 Latimeria chalumnae 55.92 0.00e+00 786.00
IUUC-Loc-052590 Lepisosteus oculatus 50.41 0.00e+00 653.00
IUUC-Laf-054526 Loxodonta africana 96.77 0.00e+00 1377.00
IUUC-Mcc-055796 Macaca mulatta 99.02 0.00e+00 1355.00
IUUC-Mga-059889 Meleagris gallopavo 81.58 0.00e+00 1145.00
IUUC-Mmr-061304 Microcebus murinus 98.04 0.00e+00 1365.00
IUUC-Mdo-062964 Monodelphis domestica 89.06 0.00e+00 1279.00
IUUC-Mmu-064268 Mus musculus 94.96 0.00e+00 1355.00
IUUC-Mpu-065817 Mustela putorius furo 95.57 0.00e+00 1169.00
IUUC-Mlu-068225 Myotis lucifugus 97.48 0.00e+00 1380.00
IUUC-Nle-069390 Nomascus leucogenys 99.44 0.00e+00 1424.00
IUUC-Opr-070274 Ochotona princeps 95.79 0.00e+00 1338.00
IUUC-Ont-072145 Oreochromis niloticus 46.26 8.00e-172 597.00
IUUC-Oan-073144 Ornithorhynchus anatinus 84.91 0.00e+00 1026.00
IUUC-Ocu-074835 Oryctolagus cuniculus 89.90 0.00e+00 1240.00
IUUC-Ola-087520 Oryzias latipes 46.92 3.00e-170 592.00
IUUC-Oga-088605 Otolemur garnettii 97.34 0.00e+00 1395.00
IUUC-Oar-089788 Ovis aries 98.04 0.00e+00 1414.00
IUUC-Ptr-091274 Pan troglodytes 100.00 0.00e+00 1434.00
IUUC-Psi-093560 Pelodiscus sinensis 79.97 0.00e+00 1010.00
IUUC-Pfo-097221 Poecilia formosa 46.70 1.00e-168 587.00
IUUC-Pab-097799 Pongo abelii 99.53 0.00e+00 1254.00
IUUC-Pva-102769 Pteropus vampyrus 97.48 0.00e+00 1363.00
IUUC-Rno-105959 Rattus norvegicus 92.10 0.00e+00 1166.00
IUUC-Sha-106613 Sarcophilus harrisii 88.64 0.00e+00 1265.00
IUUC-Sar-112951 Sorex araneus 86.39 0.00e+00 1082.00
IUUC-Ssc-115673 Sus scrofa 97.76 0.00e+00 1361.00
IUUC-Tgu-116806 Taeniopygia guttata 80.19 0.00e+00 1103.00
IUUC-Tru-117544 Takifugu rubripes 43.21 3.00e-132 465.00
IUUC-Tsy-119233 Tarsius syrichta 90.88 0.00e+00 1241.00
IUUC-Tni-120273 Tetraodon nigroviridis 57.05 6.00e-101 361.00
IUUC-Tbe-128020 Tupaia belangeri 96.76 0.00e+00 1194.00
IUUC-Ttr-128357 Tursiops truncatus 97.76 0.00e+00 1350.00
IUUC-Vpa-130487 Vicugna pacos 98.04 0.00e+00 1413.00
IUUC-Xtr-132415 Xenopus tropicalis 58.08 0.00e+00 796.00
Created Date 25-Jun-2017

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