iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092687

Ensembl Protein ID

ENSPANP00000019921.1

UniProt Accession

A0A096P3J6; A0A096P3J6_PAPAN

Protein Name

Uncharacterized protein

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000023282.1	ENSPANT00000021435.1	ENSPANP00000019921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.90e-12	45.9	344	372
ULD/UDP/UBQ/UBQ_Other	5.20e-12	45.6	234	286

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           ++ W C++CTf+N+P++++CemCs++R+c
   Q: 344  QPSWPCPSCTFINAPSRPGCEMCSTQRPC 372
           578*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           +  l+v+p++tVa L+e+++++lg+pp+ qr+++ G++L  + ++La+yg++++
   Q: 234  HVALQVHPHCTVAALQEQVFSELGFPPAVQRWVI-GRCLcVPERSLASYGVRQD 286
           556779****************************.**************99754 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAPPAGGAAA ASDLGSAAVL LTVHAAVRLL GARPDAEAQL RRLQLSADPE RPGRFRLELL 60
DAGPGAVNLE WPLESVSYTI RGPTQHELQP PPGGPGTLSL HFLNPQEAQR WAVLVRGATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCAC CAGCGGGCGG GGCGGCGGCG GCCTCGGACT TGGGCTCGGC CGCAGTGCTC 60
TTGACTGTGC ACGCCGCTGT GAGGCTGCTG GGCGCCAGGC CAGACGCCGA GGCACAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	36.84	2.40e-02	32.70
IUUC-Aml-001223	Ailuropoda melanoleuca	80.28	7.00e-125	440.00
IUUC-Apl-004151	Anas platyrhynchos	68.09	1.00e-17	80.90
IUUC-Ang-009713	Aspergillus niger	33.33	2.30e-02	33.10
IUUC-Bta-012948	Bos taurus	81.38	4.00e-136	477.00
IUUC-Cel-018155	Caenorhabditis elegans	36.54	6.40e-02	29.30
IUUC-Cja-019031	Callithrix jacchus	89.72	3.00e-141	494.00
IUUC-Cfa-020863	Canis familiaris	73.99	2.00e-105	375.00
IUUC-Cpo-022499	Cavia porcellus	75.20	4.00e-127	447.00
IUUC-Csa-023641	Chlorocebus sabaeus	97.51	7.00e-159	553.00
IUUC-Dno-029459	Dasypus novemcinctus	60.00	2.00e-59	222.00
IUUC-Dor-030914	Dipodomys ordii	65.00	5.00e-83	301.00
IUUC-Ete-032940	Echinops telfairi	70.65	2.00e-99	355.00
IUUC-Eca-033537	Equus caballus	80.28	3.00e-132	464.00
IUUC-Eeu-035176	Erinaceus europaeus	70.92	2.00e-62	232.00
IUUC-Fca-035971	Felis catus	78.40	2.00e-117	415.00
IUUC-Gmo-039219	Gadus morhua	38.19	5.00e-49	188.00
IUUC-Gac-041562	Gasterosteus aculeatus	55.56	3.00e-29	122.00
IUUC-Ggo-044678	Gorilla gorilla	90.41	1.00e-148	519.00
IUUC-Hsa-046578	Homo sapiens	93.89	2.00e-155	541.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	76.44	7.00e-132	463.00
IUUC-Mcc-055686	Macaca mulatta	89.20	2.00e-158	551.00
IUUC-Meu-055912	Macropus eugenii	51.45	2.00e-58	219.00
IUUC-Mmr-060584	Microcebus murinus	80.49	3.00e-140	491.00
IUUC-Mdo-062191	Monodelphis domestica	56.42	1.00e-79	289.00
IUUC-Mmu-063740	Mus musculus	70.72	5.00e-110	390.00
IUUC-Mpu-066878	Mustela putorius furo	77.58	2.00e-108	385.00
IUUC-Mlu-067878	Myotis lucifugus	79.73	2.00e-133	468.00
IUUC-Nle-069748	Nomascus leucogenys	93.95	5.00e-140	490.00
IUUC-Ont-072270	Oreochromis niloticus	39.56	6.00e-51	194.00
IUUC-Oga-088300	Otolemur garnettii	80.70	7.00e-145	506.00
IUUC-Oar-089549	Ovis aries	80.85	8.00e-135	473.00
IUUC-Ptr-090961	Pan troglodytes	93.33	2.00e-140	491.00
IUUC-Pfo-096865	Poecilia formosa	34.09	8.00e-38	151.00
IUUC-Pab-097872	Pongo abelii	90.03	4.00e-139	487.00
IUUC-Pca-100363	Procavia capensis	70.27	3.00e-65	242.00
IUUC-Pva-102595	Pteropus vampyrus	78.91	1.00e-115	409.00
IUUC-Rno-105856	Rattus norvegicus	70.37	9.00e-108	383.00
IUUC-Sha-106838	Sarcophilus harrisii	54.05	7.00e-67	247.00
IUUC-Sar-113611	Sorex araneus	71.58	3.00e-27	115.00
IUUC-Ssc-116263	Sus scrofa	77.51	3.00e-135	474.00
IUUC-Tru-118089	Takifugu rubripes	42.78	4.00e-56	211.00
IUUC-Tni-120004	Tetraodon nigroviridis	41.73	4.00e-46	178.00
IUUC-Tbe-127471	Tupaia belangeri	73.57	3.00e-106	378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence