iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120233

UUCD1 version

UUC-TeN-00748

Ensembl Protein ID

ENSTNIP00000016079.1

UniProt Accession

H3D6D9; H3D6D9_TETNG

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000013098.1	ENSTNIT00000016290.1	ENSTNIP00000016079.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-100	335.9	723	1046

Active Site

Position(s)	Description	Evidence
1015	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+y e+++  ++  ++      e+++lF+++G+++g+a+++  +++l
   Q: 723  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELMDPKYGMFRYYEESRLIWFSHKTF-----EEFDLFNLIGVICGLAIYNLTIVEL 804
           78999*********************************************9988766.....68*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk +l+dl+e++p++ + l+ ++++ e+d+ee+ ++l+f+++ee++g t+  eL+p+Ge+i+Vt++N++e+v+++
   Q: 805  QFPVALYKKLLKKKPTLDDLKELMPDVGRGLQALLDYTEDDLEEI-FCLNFTITEENYGATEIIELVPNGEKISVTKSNRQEFVNAY 890
           **************************************9999999.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++++++  +e f++Gf++v+  ++l+lF+++el+ ++ G++++d+ dl+k t+ykg+y +d+p+i+ Fwev++++  e++k+f
   Q: 891  VNYVFNTSVDPLFEYFYAGFHKVCGGKVLELFQPNELQAMVIGNTNYDWTDLEKSTEYKGEYWKDHPTIKLFWEVFHNLPLEKKKQF 977
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Y+s e+l+ekLl Ai++++gF+l
   Q: 978  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEHYLPVAHTCFNLLDLPKYTSIETLREKLLQAIDHNQGFNL 1046
           *******************...6666658889**************************************87 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRKCEF FHGKRVCDVG CGLKHTVFLL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEHVVA LDAQIIVAVS CGESHTLALN DKGQVFSWGL GSNGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGTGCT GGGGGAATGC CTCCTATGGA CAATTAGGAT TGGGTGGAAT TGATGAGGAG 60
ATCGTAGTTG AACCAAGAAA ATGTGAATTC TTTCACGGTA AGAGAGTCTG TGACGTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	72.14	0.00e+00	1467.00
IUUC-Apl-003295	Anas platyrhynchos	71.79	0.00e+00	1504.00
IUUC-Aca-004336	Anolis carolinensis	71.94	0.00e+00	1510.00
IUUC-Ame-010768	Astyanax mexicanus	76.16	0.00e+00	1608.00
IUUC-Bta-013279	Bos taurus	71.93	0.00e+00	1462.00
IUUC-Bdi-014791	Brachypodium distachyon	36.81	3.00e-53	202.00
IUUC-Cel-018150	Caenorhabditis elegans	34.33	2.00e-152	533.00
IUUC-Cja-019023	Callithrix jacchus	72.24	0.00e+00	1466.00
IUUC-Cfa-021074	Canis familiaris	72.12	0.00e+00	1466.00
IUUC-Cpo-021461	Cavia porcellus	70.57	0.00e+00	1425.00
IUUC-Csa-024261	Chlorocebus sabaeus	72.33	0.00e+00	1464.00
IUUC-Cin-025232	Ciona intestinalis	42.55	0.00e+00	804.00
IUUC-Dre-028829	Danio rerio	77.04	0.00e+00	1594.00
IUUC-Dno-029445	Dasypus novemcinctus	68.36	0.00e+00	1142.00
IUUC-Dor-030158	Dipodomys ordii	77.53	0.00e+00	707.00
IUUC-Dme-032103	Drosophila melanogaster	43.45	0.00e+00	838.00
IUUC-Ete-033072	Echinops telfairi	65.27	0.00e+00	1288.00
IUUC-Eca-033317	Equus caballus	71.36	0.00e+00	1453.00
IUUC-Fca-035682	Felis catus	72.50	0.00e+00	1466.00
IUUC-Fal-036969	Ficedula albicollis	71.29	0.00e+00	1501.00
IUUC-Gmo-038671	Gadus morhua	78.21	0.00e+00	1655.00
IUUC-Gga-041174	Gallus gallus	71.67	0.00e+00	1505.00
IUUC-Gac-042600	Gasterosteus aculeatus	82.75	0.00e+00	1686.00
IUUC-Gma-043616	Glycine max	39.30	5.00e-54	204.00
IUUC-Ggo-044589	Gorilla gorilla	72.02	0.00e+00	1481.00
IUUC-Hsa-046772	Homo sapiens	72.14	0.00e+00	1480.00
IUUC-Lch-050147	Latimeria chalumnae	70.47	0.00e+00	1208.00
IUUC-Loc-052684	Lepisosteus oculatus	75.59	0.00e+00	1568.00
IUUC-Laf-053844	Loxodonta africana	71.46	0.00e+00	1456.00
IUUC-Mcc-055531	Macaca mulatta	70.54	0.00e+00	1448.00
IUUC-Mga-060151	Meleagris gallopavo	69.69	0.00e+00	1218.00
IUUC-Mmr-060954	Microcebus murinus	72.14	0.00e+00	1464.00
IUUC-Mdo-062246	Monodelphis domestica	70.86	0.00e+00	1333.00
IUUC-Mmu-063369	Mus musculus	72.12	0.00e+00	1488.00
IUUC-Mpu-065936	Mustela putorius furo	71.11	0.00e+00	1329.00
IUUC-Mlu-067326	Myotis lucifugus	71.95	0.00e+00	1436.00
IUUC-Ncr-068903	Neurospora crassa	36.66	8.00e-75	275.00
IUUC-Nle-069453	Nomascus leucogenys	72.53	0.00e+00	1464.00
IUUC-Ont-071720	Oreochromis niloticus	83.81	0.00e+00	1732.00
IUUC-Oan-073464	Ornithorhynchus anatinus	70.30	0.00e+00	1334.00
IUUC-Ocu-074207	Oryctolagus cuniculus	69.20	0.00e+00	1313.00
IUUC-Ola-086762	Oryzias latipes	81.56	0.00e+00	1652.00
IUUC-Oga-088435	Otolemur garnettii	72.43	0.00e+00	1468.00
IUUC-Oar-089233	Ovis aries	71.93	0.00e+00	1462.00
IUUC-Ptr-091368	Pan troglodytes	72.14	0.00e+00	1480.00
IUUC-Pan-092300	Papio anubis	72.33	0.00e+00	1464.00
IUUC-Psi-093406	Pelodiscus sinensis	72.24	0.00e+00	1514.00
IUUC-Pma-094113	Petromyzon marinus	63.42	0.00e+00	998.00
IUUC-Ppa-095354	Physcomitrella patens	32.91	1.00e-150	527.00
IUUC-Pfo-097021	Poecilia formosa	81.27	0.00e+00	1752.00
IUUC-Pab-098327	Pongo abelii	72.14	0.00e+00	1479.00
IUUC-Pte-104055	Pyrenophora teres	27.29	2.00e-45	177.00
IUUC-Pyt-104647	Pyrenophora triticirepentis	28.32	6.00e-49	189.00
IUUC-Rno-105457	Rattus norvegicus	71.93	0.00e+00	1492.00
IUUC-Sha-106632	Sarcophilus harrisii	72.11	0.00e+00	1487.00
IUUC-Sar-113679	Sorex araneus	60.76	0.00e+00	761.00
IUUC-Tgu-116849	Taeniopygia guttata	68.18	0.00e+00	1405.00
IUUC-Tru-118206	Takifugu rubripes	90.22	0.00e+00	1833.00
IUUC-Tsy-119521	Tarsius syrichta	60.96	0.00e+00	1149.00
IUUC-Vpa-130448	Vicugna pacos	71.93	0.00e+00	1462.00
IUUC-Xtr-132719	Xenopus tropicalis	64.05	0.00e+00	1222.00
IUUC-Xma-133389	Xiphophorus maculatus	80.42	0.00e+00	1733.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence