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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063110
UUCD1 version UUC-MuM-00667
Ensembl Protein ID ENSMUSP00000083393.4
UniProt Accession Q8BTZ4; Q3TGA7; Q80UJ6; Q80W43; Q8BWW7; Q8C0F7; Q9CRX0; Q9CSL1; Q9JJB8; APC5_MOUSE
Genbank Protein ID BAA95076.1; BAB28331.1; BAB29097.1; BAC27401.1; BAC33891.1; BAC40284.1; BAE35479.1; BAE40641.1; BAE40972.1; AAH10339.1; AAH46566.1; AAH46804.1
Protein Name Anaphase-promoting complex subunit 5; Cyclosome subunit 5
Genbank Nucleotide ID AB041593; AK012579; AK013978; AK031432; AK049719; AK088327; AK159916; AK168814; AK169196; BC010339; BC046566; BC046804
Gene Name Anapc5; MNCb-2778
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029472.13 ENSMUST00000086216.8 ENSMUSP00000083393.4
ENSMUSG00000029472.13 ENSMUST00000196423.4 ENSMUSP00000143169.1
ENSMUSG00000029472.13 ENSMUST00000196640.4 ENSMUSP00000142429.1
ENSMUSG00000029472.13 ENSMUST00000197719.4 ENSMUSP00000142579.1
ENSMUSG00000029472.13 ENSMUST00000197074.4 ENSMUSP00000143053.1
ENSMUSG00000029472.13 ENSMUST00000199406.4 ENSMUSP00000142341.1
ENSMUSG00000029472.13 ENSMUST00000200645.4 ENSMUSP00000142922.1
ENSMUSG00000029472.13 ENSMUST00000199130.1 ENSMUSP00000143535.1
ENSMUSG00000029472.13 ENSMUST00000199191.1 ENSMUSP00000143078.1
ENSMUSG00000029472.13 ENSMUST00000200148.4 ENSMUSP00000143457.1
ENSMUSG00000029472.13 ENSMUST00000199926.1 ENSMUSP00000142981.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 94.35 0.00e+00 1405.00 IUUC-Hsa-047014
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MMTNGVVHAN LFGIKDWVTP YKIAVLVLLN EMGRTGEGAV SLVERRKLNQ LLLPLLQGPD 60
ITLSKLYKLI EESCPQLANS VQIRIKLMAE GELKDMEQFF DDLSDSFSGT EPEVHKTSVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063110|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTCGAAGGC ACCGCCGGGG TGGGAGAGGG ACACTGAGGC CCCCGCTACT GTGGGAAACA 60
GTCTTGGGCG GGTTAAGGTG CCGGGCGGCT GCAGCCATGG CGTAAAGGCG GCTCGTGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063110|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR026000--Apc5_dom
IPR011990--TPR-like_helical_dom
Pfam

PF12862--ANAPC5
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
KEGG mmu:59008
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000646 Aegilops tauschii 27.01 9.00e-13 69.30
IUUC-Aml-001228 Ailuropoda melanoleuca 92.61 0.00e+00 1372.00
IUUC-Atr-003077 Amborella trichopoda 35.71 7.00e-04 35.80
IUUC-Apl-003267 Anas platyrhynchos 82.57 0.00e+00 1241.00
IUUC-Aly-005908 Arabidopsis lyrata 37.86 6.00e-11 63.20
IUUC-Ath-007298 Arabidopsis thaliana 36.94 1.00e-11 65.50
IUUC-Acl-008249 Aspergillus clavatus 26.57 6.00e-15 76.30
IUUC-Afl-008627 Aspergillus flavus 28.15 1.00e-13 72.00
IUUC-Afu-008849 Aspergillus fumigatus 26.06 4.00e-15 76.60
IUUC-Ani-009400 Aspergillus nidulans 24.09 2.00e-11 64.30
IUUC-Ang-009751 Aspergillus niger 27.27 2.00e-15 78.20
IUUC-Aor-010070 Aspergillus oryzae 28.57 1.00e-14 74.30
IUUC-Ate-010499 Aspergillus terreus 26.26 7.00e-16 79.30
IUUC-Ame-011897 Astyanax mexicanus 61.17 0.00e+00 866.00
IUUC-Bgr-012227 Blumeria graminis 25.91 5.00e-13 70.10
IUUC-Bta-013451 Bos taurus 93.67 0.00e+00 1348.00
IUUC-Bci-013682 Botrytis cinerea 22.35 3.00e-16 80.50
IUUC-Bdi-014911 Brachypodium distachyon 26.58 8.00e-15 76.30
IUUC-Bol-015869 Brassica oleracea 36.94 2.00e-11 65.10
IUUC-Bra-017532 Brassica rapa 36.94 2.00e-11 65.10
IUUC-Cel-018109 Caenorhabditis elegans 20.56 9.00e-05 42.70
IUUC-Cja-019568 Callithrix jacchus 94.62 0.00e+00 1390.00
IUUC-Cfa-020050 Canis familiaris 93.54 0.00e+00 1372.00
IUUC-Cpo-021705 Cavia porcellus 90.82 0.00e+00 1345.00
IUUC-Csa-023099 Chlorocebus sabaeus 92.60 0.00e+00 1358.00
IUUC-Cho-024968 Choloepus hoffmanni 79.81 0.00e+00 644.00
IUUC-Cin-025286 Ciona intestinalis 27.09 2.00e-26 112.00
IUUC-Cgl-026397 Colletotrichum gloeosporioides 26.32 4.00e-13 70.10
IUUC-Dre-028446 Danio rerio 62.42 0.00e+00 900.00
IUUC-Dno-029248 Dasypus novemcinctus 93.00 0.00e+00 1349.00
IUUC-Dor-030713 Dipodomys ordii 89.47 0.00e+00 1175.00
IUUC-Dse-031480 Dothistroma septosporum 24.41 4.00e-06 47.00
IUUC-Dme-031636 Drosophila melanogaster 25.36 2.00e-34 140.00
IUUC-Ete-032483 Echinops telfairi 91.79 0.00e+00 1348.00
IUUC-Eca-033381 Equus caballus 94.35 0.00e+00 1370.00
IUUC-Eeu-034557 Erinaceus europaeus 68.82 0.00e+00 670.00
IUUC-Fca-035995 Felis catus 96.07 0.00e+00 1016.00
IUUC-Fal-037344 Ficedula albicollis 83.04 0.00e+00 1218.00
IUUC-Fox-038064 Fusarium oxysporum 21.24 9.00e-11 62.40
IUUC-Fso-038085 Fusarium solani 22.98 1.00e-12 68.90
IUUC-Ggr-040022 Gaeumannomyces graminis 28.57 4.00e-09 57.40
IUUC-Gga-040306 Gallus gallus 82.35 0.00e+00 1230.00
IUUC-Gac-042229 Gasterosteus aculeatus 63.41 0.00e+00 908.00
IUUC-Gma-042708 Glycine max 28.77 1.00e-13 72.00
IUUC-Ggo-045040 Gorilla gorilla 94.21 0.00e+00 1390.00
IUUC-Hsa-047014 Homo sapiens 94.35 0.00e+00 1392.00
IUUC-Hvu-047209 Hordeum vulgare 26.44 1.00e-14 75.90
IUUC-Itr-047936 Ictidomys tridecemlineatus 94.98 0.00e+00 830.00
IUUC-Lch-049595 Latimeria chalumnae 74.16 0.00e+00 1103.00
IUUC-Lpe-051682 Leersia perrieri 25.67 7.00e-15 76.30
IUUC-Loc-052640 Lepisosteus oculatus 71.71 0.00e+00 1050.00
IUUC-Lma-052954 Leptosphaeria maculans 24.22 4.00e-04 40.40
IUUC-Laf-054391 Loxodonta africana 92.87 0.00e+00 1340.00
IUUC-Mcc-055384 Macaca mulatta 94.35 0.00e+00 1392.00
IUUC-Meu-056410 Macropus eugenii 81.41 0.00e+00 738.00
IUUC-Mor-057156 Magnaporthe oryzae 24.52 5.00e-10 60.10
IUUC-Mpo-057453 Magnaporthe poae 25.22 4.00e-10 59.70
IUUC-Mtr-058102 Medicago truncatula 26.38 7.00e-12 66.20
IUUC-Mla-059063 Melampsora laricipopulina 35.29 1.00e-03 38.90
IUUC-Mga-059991 Meleagris gallopavo 83.85 0.00e+00 1165.00
IUUC-Mmr-060939 Microcebus murinus 93.54 0.00e+00 1337.00
IUUC-Mdo-062775 Monodelphis domestica 86.96 0.00e+00 1285.00
IUUC-Mac-065555 Musa acuminata 30.28 6.00e-16 79.70
IUUC-Mpu-066382 Mustela putorius furo 93.44 0.00e+00 1286.00
IUUC-Mlu-067724 Myotis lucifugus 88.29 0.00e+00 1280.00
IUUC-Nfi-068251 Neosartorya fischeri 27.34 4.00e-15 77.00
IUUC-Ncr-068757 Neurospora crassa 21.82 2.00e-12 68.20
IUUC-Nle-069022 Nomascus leucogenys 94.35 0.00e+00 1392.00
IUUC-Opr-070727 Ochotona princeps 93.01 0.00e+00 1045.00
IUUC-Ont-071409 Oreochromis niloticus 63.64 0.00e+00 931.00
IUUC-Oan-073732 Ornithorhynchus anatinus 87.90 0.00e+00 786.00
IUUC-Oba-075329 Oryza barthii 24.87 7.00e-12 66.60
IUUC-Obr-076176 Oryza brachyantha 25.00 4.00e-14 73.90
IUUC-Ogl-076949 Oryza glaberrima 26.18 6.00e-15 76.60
IUUC-Ogu-078835 Oryza glumaepatula 24.87 7.00e-12 66.60
IUUC-Oin-079783 Oryza indica 25.87 2.00e-12 67.80
IUUC-Olo-080921 Oryza longistaminata 23.98 2.00e-11 65.10
IUUC-Ome-081983 Oryza meridionalis 25.74 8.00e-15 76.60
IUUC-Oni-082649 Oryza nivara 24.87 7.00e-12 66.60
IUUC-Opu-083962 Oryza punctata 25.20 5.00e-15 77.00
IUUC-Oru-085221 Oryza rufipogon 24.87 7.00e-12 66.60
IUUC-Osa-086035 Oryza sativa 26.13 8.00e-15 76.30
IUUC-Ola-087386 Oryzias latipes 62.72 0.00e+00 916.00
IUUC-Olu-087848 Ostreococcus lucimarinus 24.82 1.00e-03 38.90
IUUC-Oga-089166 Otolemur garnettii 94.75 0.00e+00 1338.00
IUUC-Oar-090437 Ovis aries 93.42 0.00e+00 1342.00
IUUC-Ptr-090917 Pan troglodytes 94.35 0.00e+00 1392.00
IUUC-Pan-091739 Papio anubis 93.68 0.00e+00 1357.00
IUUC-Psi-093776 Pelodiscus sinensis 83.07 0.00e+00 1178.00
IUUC-Pma-094696 Petromyzon marinus 34.83 6.00e-43 168.00
IUUC-Pno-094995 Phaeosphaeria nodorum 23.79 1.00e-03 38.10
IUUC-Ppa-095754 Physcomitrella patens 36.43 1.00e-12 68.60
IUUC-Pfo-096997 Poecilia formosa 61.49 0.00e+00 887.00
IUUC-Pab-098518 Pongo abelii 94.35 0.00e+00 1392.00
IUUC-Pop-099568 Populus trichocarpa 24.49 2.00e-10 61.60
IUUC-Pca-100400 Procavia capensis 84.39 0.00e+00 1152.00
IUUC-Ppe-101627 Prunus persica 25.29 1.00e-14 75.90
IUUC-Pva-103252 Pteropus vampyrus 88.29 0.00e+00 1291.00
IUUC-Pte-104302 Pyrenophora teres 23.17 7.00e-04 39.70
IUUC-Pyt-104585 Pyrenophora triticirepentis 22.76 4.00e-04 40.40
IUUC-Rno-104876 Rattus norvegicus 98.65 0.00e+00 1466.00
IUUC-Sha-107267 Sarcophilus harrisii 87.18 0.00e+00 1079.00
IUUC-Sja-107719 Schizosaccharomyces japonicus 25.65 8.00e-10 59.30
IUUC-Spo-108363 Schizosaccharomyces pombe 25.88 7.00e-09 56.20
IUUC-Ssl-108557 Sclerotinia sclerotiorum 22.07 2.00e-11 64.70
IUUC-Smo-109037 Selaginella moellendorffii 24.05 1.00e-11 65.10
IUUC-Sit-110705 Setaria italica 26.33 2.00e-15 78.20
IUUC-Sly-111864 Solanum lycopersicum 35.04 8.00e-12 66.20
IUUC-Sar-113485 Sorex araneus 83.98 0.00e+00 1251.00
IUUC-Sbi-114673 Sorghum bicolor 25.72 4.00e-15 77.00
IUUC-Sre-115155 Sporisorium reilianum 40.38 4.00e-03 37.00
IUUC-Ssc-115301 Sus scrofa 93.54 0.00e+00 1391.00
IUUC-Tgu-116928 Taeniopygia guttata 82.88 0.00e+00 1221.00
IUUC-Tru-117756 Takifugu rubripes 61.16 0.00e+00 853.00
IUUC-Tsy-119155 Tarsius syrichta 78.60 0.00e+00 1131.00
IUUC-Tni-120285 Tetraodon nigroviridis 61.26 0.00e+00 838.00
IUUC-Tca-121305 Theobroma cacao 32.37 2.00e-11 65.10
IUUC-Tre-122123 Trichoderma reesei 25.34 2.00e-12 67.80
IUUC-Tvi-122313 Trichoderma virens 23.81 5.00e-12 66.60
IUUC-Tae-125147 Triticum aestivum 27.23 2.00e-15 78.20
IUUC-Tur-126507 Triticum urartu 26.81 3.00e-15 77.40
IUUC-Tme-127132 Tuber melanosporum 24.21 9.00e-17 82.40
IUUC-Tbe-127653 Tupaia belangeri 81.62 0.00e+00 723.00
IUUC-Ttr-129200 Tursiops truncatus 93.14 0.00e+00 1364.00
IUUC-Uma-129658 Ustilago maydis 25.16 1.00e-03 38.90
IUUC-Vda-129916 Verticillium dahliae 25.93 1.00e-09 58.90
IUUC-Vpa-130494 Vicugna pacos 85.99 0.00e+00 1111.00
IUUC-Vvi-131317 Vitis vinifera 36.61 1.00e-10 61.60
IUUC-Xtr-132765 Xenopus tropicalis 78.79 0.00e+00 1171.00
IUUC-Xma-133195 Xiphophorus maculatus 63.86 0.00e+00 773.00
IUUC-Yli-134672 Yarrowia lipolytica 45.28 5.00e-06 46.60
IUUC-Zma-135338 Zea mays 27.30 4.00e-16 80.50
Created Date 25-Jun-2017

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