iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118180

UUCD1 version

UUC-TaR-00253

Ensembl Protein ID

ENSTRUP00000012899.1

UniProt Accession

H2SKG6; H2SKG6_TAKRU

Protein Name

Histone deacetylase

Gene Name

hdac4 (1 of many); hdac4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000005375.1	ENSTRUT00000012960.1	ENSTRUP00000012899.1
ENSTRUG00000005375.1	ENSTRUT00000012961.1	ENSTRUP00000012900.1
ENSTRUG00000005375.1	ENSTRUT00000012962.1	ENSTRUP00000012901.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	70.14	0.00e+00	1285.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Takifugu rubripes

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

LSHFPVDVSA AALPMQVPPA ATAILPMDLR VDHHHNHQQQ PTFDHQEQQL QQELVALKHK 60
QQLQRQLLIA EFQRQHEQLS RQHEIQLQEH IKHQQDLLAL KHQQELLEHQ RKIEQQRHEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTCTCATT TTCCAGTGGA CGTGAGCGCA GCAGCACTGC CCATGCAGGT GCCCCCCGCA 60
GCTACAGCCA TCCTCCCCAT GGACCTGCGT GTAGACCACC ACCACAACCA CCAGCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR011990--TPR-like_helical_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	72.75	0.00e+00	1249.00
IUUC-Apl-003250	Anas platyrhynchos	83.16	0.00e+00	850.00
IUUC-Aca-004668	Anolis carolinensis	79.96	0.00e+00	843.00
IUUC-Bta-013215	Bos taurus	72.89	0.00e+00	1241.00
IUUC-Cja-019816	Callithrix jacchus	69.90	0.00e+00	1266.00
IUUC-Cfa-020861	Canis familiaris	72.81	0.00e+00	1234.00
IUUC-Cpo-021562	Cavia porcellus	69.29	0.00e+00	1258.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	50.67	6.00e-53	200.00
IUUC-Csa-023612	Chlorocebus sabaeus	69.95	0.00e+00	1244.00
IUUC-Csv-026359	Ciona savignyi	53.04	1.00e-88	319.00
IUUC-Dre-028284	Danio rerio	86.60	0.00e+00	862.00
IUUC-Dno-029951	Dasypus novemcinctus	75.63	0.00e+00	780.00
IUUC-Dor-030362	Dipodomys ordii	61.24	0.00e+00	999.00
IUUC-Dme-031766	Drosophila melanogaster	57.96	2.00e-153	536.00
IUUC-Fca-036187	Felis catus	73.77	0.00e+00	1285.00
IUUC-Gmo-038473	Gadus morhua	80.51	0.00e+00	771.00
IUUC-Gga-040501	Gallus gallus	83.16	0.00e+00	850.00
IUUC-Gac-042335	Gasterosteus aculeatus	84.69	0.00e+00	1506.00
IUUC-Ggo-045380	Gorilla gorilla	69.84	0.00e+00	1235.00
IUUC-Hsa-046925	Homo sapiens	70.21	0.00e+00	1258.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	70.07	0.00e+00	1241.00
IUUC-Lch-050325	Latimeria chalumnae	77.82	0.00e+00	806.00
IUUC-Loc-052231	Lepisosteus oculatus	85.10	0.00e+00	838.00
IUUC-Laf-054490	Loxodonta africana	67.00	0.00e+00	1201.00
IUUC-Mcc-055265	Macaca mulatta	69.57	0.00e+00	1247.00
IUUC-Meu-056676	Macropus eugenii	77.27	3.00e-179	622.00
IUUC-Mmr-061633	Microcebus murinus	64.85	0.00e+00	1095.00
IUUC-Mmu-063089	Mus musculus	82.04	0.00e+00	832.00
IUUC-Mpu-065887	Mustela putorius furo	72.99	0.00e+00	1246.00
IUUC-Mlu-067470	Myotis lucifugus	71.04	0.00e+00	1268.00
IUUC-Nle-069099	Nomascus leucogenys	63.47	0.00e+00	717.00
IUUC-Ont-071613	Oreochromis niloticus	81.74	0.00e+00	1473.00
IUUC-Oan-073275	Ornithorhynchus anatinus	79.27	0.00e+00	846.00
IUUC-Ola-087031	Oryzias latipes	83.16	0.00e+00	1449.00
IUUC-Oga-088201	Otolemur garnettii	82.19	0.00e+00	814.00
IUUC-Oar-089997	Ovis aries	66.88	0.00e+00	1058.00
IUUC-Ptr-091116	Pan troglodytes	70.31	0.00e+00	1274.00
IUUC-Pan-092132	Papio anubis	70.64	0.00e+00	865.00
IUUC-Psi-093734	Pelodiscus sinensis	82.39	0.00e+00	815.00
IUUC-Pma-094347	Petromyzon marinus	68.75	0.00e+00	673.00
IUUC-Pfo-096293	Poecilia formosa	81.06	0.00e+00	1434.00
IUUC-Pab-098491	Pongo abelii	67.53	0.00e+00	1169.00
IUUC-Pca-101004	Procavia capensis	67.71	6.00e-94	339.00
IUUC-Pva-102961	Pteropus vampyrus	54.86	2.00e-174	606.00
IUUC-Rno-105005	Rattus norvegicus	81.63	0.00e+00	825.00
IUUC-Sha-107646	Sarcophilus harrisii	72.29	1.00e-166	580.00
IUUC-Ssc-115428	Sus scrofa	71.00	0.00e+00	1237.00
IUUC-Tgu-116776	Taeniopygia guttata	83.61	0.00e+00	848.00
IUUC-Tsy-119468	Tarsius syrichta	60.31	5.00e-144	505.00
IUUC-Tni-120196	Tetraodon nigroviridis	90.27	0.00e+00	1582.00
IUUC-Ttr-128360	Tursiops truncatus	65.68	0.00e+00	761.00
IUUC-Xtr-132956	Xenopus tropicalis	76.12	0.00e+00	806.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence